Haskap Berry Phenolic Subclasses Differentially Impact Cellular Stress Sensing in Primary and Immortalized Dermal Fibroblasts

Zehfus, Lily R.; Gillespie, Zoe E.; Almendáriz-Palacios, Carla; Low, Nicholas H.; Eskiw, Christopher H.

doi:10.3390/cells10102643

Cited by 6 publications

(5 citation statements)

References 38 publications

(47 reference statements)

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“…No sucrose was detected in each treatment by enzymatic assays. Sucrose was also not detected by HPLC in some prior research; however, a trace quantity of sucrose (less than 0.2 g/100 FW) was detected in some publications [3,51]. Ultimately, the sucrose amount may be trivially low in both haskap fruit and haskap juice based on this and prior research.…”

Section: Carbohydrate Content In Processed Haskap Juicementioning

confidence: 68%

Haskap Juicing Method Effects on Haskap Juice Quality

Wang,

Svyantek,

Miller

et al. 2023

Applied Sciences

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This research is the first study on the influence of juicing methods on the ‘Aurora’ haskap juice quality. Three common juice extraction methods, namely, using a steam juicer, a centrifugal juicer, and a bladder wine press, were applied for haskap juice extraction. Both physicochemical assays and tests of antioxidant activities were employed to evaluate the qualities of the haskap juice. Generally, the centrifugal juicer increased and the steam juicer reduced concentrations of measured juice components relative to the press. The juice from the centrifugal juicer had the highest cloudiness. Sugar concentrations were about 40% lower in steam juice compared to the centrifugal juicer. Pressed juice had a slightly lower soluble solid content than the juice made with the centrifugal juicer and concentrations of glucose and fructose were similar between these methods. The methods altered pH and malic acid content without affecting the concentrations of tartaric and malic acids. Similar effects of juicing methods were seen in secondary compounds associated with health benefits and antioxidant capacities. Anthocyanin concentrations in press and centrifugal juicer extracts were similar, about 1.6 times higher than steam juicer extracts. Total phenolics and antioxidant activities were from two to four times higher in the centrifugal juicer extraction compared to steam juicing. Ascorbic acid and total flavonoid content in the haskap juice was increased by centrifugal juicing and decreased by steam juicing compared to the press. Overall, the juice extracted with the centrifugal juicer had concentrations of juice components that were 1.5–2 times higher than the steam juicer. The pressed juice had similar to slightly lower concentrations of components compared to the centrifugal juicer.

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Section: Carbohydrate Content In Processed Haskap Juicementioning

confidence: 68%

Haskap Juicing Method Effects on Haskap Juice Quality

Wang,

Svyantek,

Miller

et al. 2023

Applied Sciences

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“…Despite the high value attributed to the Kamchatka berry fruit, which is characterized by high anti-inflammatory activity and antioxidant potential, the fruit has also found application in potential diabetes therapy thanks to the ability to inhibit enzymes responsible for the breakdown of carbohydrates into simple sugars [ 39 , 40 , 41 ]. Leaves of haskap berry, a new potential source of biologically active compounds, have not been tested so far.…”

Section: Resultsmentioning

confidence: 99%

Haskap Berry Leaves (Lonicera caerulea L.)—The Favorable Potential of Medical Use

Sip

Szulc

et al. 2022

Nutrients

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The presented research evaluates the medical use potential of Lonicera caerulea leaves, which are waste plants in cultivating berries. The study’s screening activity included the leaves of five varieties of Lonicera caerulea: Atut, Duet, Wojtek, Zojka, and Jugana. The microbiological analysis confirmed the safety of using Lonicera caerulea leaves without significant stabilization. Lonicera caerulea leaves standardization was carried out based on the results of the chromatographic analysis, and it showed differences in the contents of active compounds (loganic, chlorogenic and caffeic acids, and rutin), which are attributed to biological activity. For the Lonicera caerulea leaves varieties tested, the differences in the content of total polyphenol content, chlorophylls, and carotenoids were also confirmed. The screening of biological activity of five Lonicera caerulea leaf varieties was carried out concerning the possibility of inhibiting the activity of α-glucosidase, lipase, and hyaluronidase as well, and the antioxidant potential was determined. The defined profile of the biological activity of Lonicera caerulea leaves makes it possible to indicate this raw material as an essential material supporting the prevention and treatment of type II diabetes. However, this research showed that tested enzymes were strongly inhibited by the variety Jugana. The health-promoting potential of Lonicera caerulea leaves was correlated with the highest chlorogenic acid and rutin content in the variety Jugana.

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“…These (poly)phenols are proposed to reduce fatigue and increase exercise performance [51,52]. A recent addition to the literature demonstrated reduced in vitro intracellular free radicals of fibroblasts with exposure to isolated Haskap berry extracts [53], but this has yet to be demonstrated in humans. Nonetheless, there is now convincing evidence that these types of phytochemicals induce enzymatic antioxidants, such as superoxide dismutase, by activation the transcription factor nuclear factor-erythroid-2-related factor 2; Nrf2 [54,55] that enable defence against redox challenges.…”

Section: Discussionmentioning

confidence: 99%

Improved Endurance Running Performance Following Haskap Berry (Lonicera caerulea L.) Ingestion

et al. 2022

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Background: Food high in (poly)phenolic compounds, such as anthocyanins, have the potential to improve exercise recovery and exercise performance. Haskap berries are rich in anthocyanins, but no research has examined the potential to improve human performance. The aim of this study was to determine the influence of Haskap berry on parameters of endurance running performance. Methods: Using a double-blind, placebo controlled, independent groups design, 30 male recreational runners (mean ± SD age, 33 ± 7 years; stature, 178.2 ± 7.2 cm; mass, 77.7 ± 10.6 kg; V˙O2peak, 52.2 ± 6.6 mL/kg/min) volunteered to participate. Following familiarisation, volunteers visited the laboratory twice (separated by seven days) to assess submaximal, maximal and 5 km time trial running performance. After the first visit, volunteers were randomly assigned to consume either the Haskap berry intervention or an isocaloric placebo control. Results: There were modest changes in heart rate and V˙O2 at submaximal intensities (p < 0.05). Time to exhaustion during the V˙O2peak test was longer in the Haskap group by 20 s (p = 0.031). Additionally, 5 km time trial performance was improved in the Haskap group by ~21 s (p = 0.016), which equated to a 0.25 km/h increase in mean running speed compared to the placebo control; this represented a >2% improvement in running performance. Conclusions: The application of this newly identified functional food to athletes has the capacity to improve endurance running performance.

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Haskap Berry Phenolic Subclasses Differentially Impact Cellular Stress Sensing in Primary and Immortalized Dermal Fibroblasts

Cited by 6 publications

References 38 publications

Haskap Juicing Method Effects on Haskap Juice Quality

Haskap Juicing Method Effects on Haskap Juice Quality

Haskap Berry Leaves (Lonicera caerulea L.)—The Favorable Potential of Medical Use

Improved Endurance Running Performance Following Haskap Berry (Lonicera caerulea L.) Ingestion

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