Hashimoto's Thyroiditis, Myasthenia Gravis, Idiopathic Thrombocytopenic Purpura

Segal, Barry M.

doi:10.7326/0003-4819-85-6-761

Cited by 29 publications

(13 citation statements)

References 5 publications

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“…In addition, AITP has also been reported in patients with Hashimoto's thyroiditis (16,38), and both diseases may further be associated with myasthenia gravis (39,40). Moreover, an association between Graves' disease and congenital prekallikrein (Fletcher factor) deficiency, a coagulation disorder characterized by marked prolongation of partial thromboplastin time, has been reported (41,42).…”

Section: Introductionmentioning

confidence: 98%

Coagulation disorders in thyroid diseases

Hofbauer

Heufelder²

1997

European Journal of Endocrinology

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Section: Introductionmentioning

confidence: 98%

Coagulation disorders in thyroid diseases

Hofbauer

Heufelder²

1997

European Journal of Endocrinology

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“…A genetic predisposition to both Graves' disease and AITP was highlighted by Bizzarro [26] who found these two disorders in three female relatives, all of whom were positive for HLA-B8 and DR3 phenotypes. Graves' disease or Hashimoto thyroiditis and AITP have also been reported in association with other autoimmune disorders such as myasthenia gravis [18,21,30], Guillain-Barre syndrome [29], insulindependent diabetes mellitus [19], celiac disease [37], and Evans' syndrome (a condition characterized autoimmune hemolytic anemia and AITP) [20,24,25,28]. On the other hand, some investigators have analyzed the prevalence of thyroid disorders in patients with AITP.…”

Section: Introductionmentioning

confidence: 99%

Thyroid-associated autoimmune coagulation disorders

Franchini

Lippi

Manzato

et al. 2009

J Thromb Thrombolysis

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Abnormalities of blood coagulation are not rarely observed in patients with thyroid dysfunctions and may range from subclinical laboratory abnormalities to clinically significant hemorrhagic or thrombotic complications. In this review, we summarize the current knowledge on thyroid-associated autoimmune coagulation disorders (i.e., autoimmune thrombocytopenic purpura, antiphospholipid syndrome, and autoantibodies against coagulation factor VIII) and discuss their laboratory characteristics, clinical impact, and recent progresses in the understanding of pathogenesis. Finally, we conclude that the prompt recognition of possible concomitant autoimmune coagulation disorders is important for the correct management of these patients.

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“…We recently demonstrated that, regardless of the presence or absence of thrombocytopenia, platelet autoantibodies are present in systemic lupus erythematosus (SLE) and in primary antiphospholipid syndrome, and, as in patients with primary AITP, are directed against the same antigens [7]. Thrombocytopenia may also be observed in patients with TAD, especially those with hyperthyroidism [8][9][10][11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Autoimmune thrombocytopenia (AITP) and thyroid autoimmune disease (TAD): overlapping syndromes?

Cordiano

Betterle

Spadaccino

et al. 1998

Clinical and Experimental Immunology

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The pathogenesis of thrombocytopenia associated with TAD and the occurrence of overlapping traits between TAD and AITP are still a matter of debate. For this reason, we investigated for the presence and specificity of platelet and thyroid autoantibodies in 18 TAD patients with thrombocytopenia, 19 TAD patients without thrombocytopenia and in 22 patients with primary AITP without clinical signs of TAD. Platelet-associated IgG and/or specific circulating platelet autoantibodies were detected in 83% of patients with TAD and thrombocytopenia, in 10% of patients with TAD without thrombocytopenia and in 86% of patients with primary AITP. The reactivity of serum autoantibodies, assayed by MoAb immobilization of platelet antigens (MAIPA), was directed against platelet glycoproteins Ib and/or IIb/IIIa in 50% of the patients with TAD and thrombocytopenia, as in 46% of the patients with primary AITP. Thyroid autoantibodies were found in 89% of patients with TAD and thrombocytopenia, in 95% of patients with TAD without thrombocytopenia, and in 18% of patients with primary AITP. Thyrotropin (TSH) levels determined in three of four AITP patients with thyroid autoantibodies revealed a subclinical hyperthyroidism in one patient. The present study supports the autoimmune aetiology of thrombocytopenia associated with TAD, since the prevalence and specificity of platelet autoantibodies are similar in TAD and primary AITP. The results indicate also that there exists an overlap between thyroid and platelet autoimmunity with or without clinical manifestations.

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Hashimoto's Thyroiditis, Myasthenia Gravis, Idiopathic Thrombocytopenic Purpura

Cited by 29 publications

References 5 publications

Coagulation disorders in thyroid diseases

Coagulation disorders in thyroid diseases

Thyroid-associated autoimmune coagulation disorders

Autoimmune thrombocytopenia (AITP) and thyroid autoimmune disease (TAD): overlapping syndromes?

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