Hashimoto’s thyroiditis might increase polycystic ovary syndrome and associated comorbidities risks in Asia

Ho, Chun-Wei; Chen, Hsin-Hung; Hsieh, Meng-Hsuan; Chen, Ching‐Chu; Hsu, Sandy Huey-Jen; Yip, Hei-Tung; Kao, Chia‐Hung

doi:10.21037/atm-19-4763

Cited by 10 publications

(10 citation statements)

References 32 publications

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“…Its key characteristics are persistent anovulation, hyperandrogenism, and insulin resistance. The main manifestations are menstrual disorders and reproductive dysfunction (2)(3)(4), one of the leading causes of females in anovulatory infertility (5,6). The World Health Organization estimates PCOS has affected over 116 million women worldwide as of 2010 (7).…”

Section: Introductionmentioning

confidence: 99%

The prevalence of polycystic ovarian syndrome in Chinese women: a meta-analysis

Wu¹,

Gao²,

Bai³

et al. 2021

Ann Palliat Med

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Section: Introductionmentioning

confidence: 99%

The prevalence of polycystic ovarian syndrome in Chinese women: a meta-analysis

Wu¹,

Gao²,

Bai³

et al. 2021

Ann Palliat Med

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“…It can also increase the risk of mood disorders, cardiovascular and cerebrovascular diseases, type 2 diabetes, venous thromboembolism, pregnancy diseases, endometrial cancer, and other diseases (1)(2)(3). The pathogenesis of PCOS has not been fully elucidated, but current studies have shown that HA, inflammation, and oxidative damage jointly play a vicious cycle in the pathophysiology of the disease (4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D improves levels of hormonal, oxidative stress and inflammatory parameters in polycystic ovary syndrome: a meta-analysis study

Zhao¹,

Li²,

Zhang³

2021

Ann Palliat Med

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Background: Hyperandrogenism (HA), inflammation, and oxidative damage play key roles in the pathophysiology of polycystic ovary syndrome (PCOS). Whether vitamin D adjuvant therapy improves hormonal, inflammation, and oxidative damage in PCOS patients has aroused widespread interest, but the results are controversial. To evaluate the effect of vitamin D supplementation on hormonal, oxidative stress, and inflammatory parameters in patients with PCOS.Methods: A literature search was conducted in Medline, the Cochrane Library, EMBASE, and Web of Science for studies related to PCOS and vitamin D supplementation. All reports of randomized controlled trials (RCTs) published before December 2019 were identified. The fixed-effects model or randomeffects model was used to calculate pooled estimates of standardized differences in means (SMD) with 95% confidence intervals (CI).Results: A total of 956 identified studies were retrieved, and eighteen RCTs involving 1,060 participants were ultimately included in the current meta-analysis. The pooled results demonstrated that vitamin D supplementation in patients with PCOS resulted in a significant improvement in serum total testosterone (TT), high sensitivity C-reactive protein (hs-CRP), total antioxidant capacity (TAC), and malondialdehyde (MDA).No significant effect on free testosterone (FT), dehydroepiandrosterone sulfate (DHEA-S), sex hormonebinding globulin (SHBG), free androgen index (FAI), nitric oxide (NO), and total glutathione (GSH) levels was found. Subgroup analysis showed that vitamin D supplementation reduced hs-CRP and MDA irrespective of the treatment course, type of vitamin D intervention, supplementation frequency, and dosage. Twelve weeks of vitamin D supplementation improved TT and TAC while low-dose vitamin D supplementation (≤1,000 IU/day) improved TT and DHEA-S. Vitamin D co-supplementation reduced TT, FT, and DHEA-S, while a daily supplementation regime improved TT, DHEA-S, and TAC in patients with PCOS. Conclusions:The current meta-analysis demonstrates that vitamin D supplementation in patients with PCOS resulted in an improvement in the levels of TT, hs-CRP, TAC, and MDA, but did not affect FT, DHEA-S, SHBG, FAI, NO, and GSH levels. Vitamin D co-supplementation, low-dose vitamin D supplementation (≤1,000 IU/day), and daily supplementation frequency appeared to be more conducive to improving hormones, inflammation, and oxidative stress in PCOS patients.

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“…(PCOS) (3). A potentially helpful alternative for women with PCOS is to remove mature oocytes from small antral follicles early, without hormone stimulation, and then perform in vitro maturation (IVM) of oocytes (4).…”

Section: Introductionmentioning

confidence: 99%

Comparison of in vitro maturation and in vitro fertilization for polycystic ovary syndrome patients: a systematic review and meta-analysis

Xu¹,

Qiao²

2021

Ann Transl Med

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Background: There are two common treatments for polycystic ovary syndrome (PCOS): in vitro fertilization (IVF) and in vitro maturation (IVM). Our study aimed to assess the clinical effects and safety of IVM versus IVF for PCOS.Methods: We searched randomized controlled trials and retrospective cohort studies comparing IVM versus IVF for PCOS. Data were extracted from eligible studies. We sought to evaluate fertilization rate, clinical pregnancy rate, live birth rate, and miscarriage. Results were expressed as risk ratio (RR) with 95% confidence intervals (CIs).Results: Eight studies with a total of 1,579 patients were included in the present study. According to the heterogeneity analysis, there were no differences between the IVM group and IVF group in terms of fertilization rate, clinical pregnancy rate and miscarriage. Additionally, the IVF group had a higher live birth rate than the IVM group (overall P=0.0007). Sensitivity analysis and funnel plot showed that our study was robust and based on the funnel plot this article had low publication bias. Discussion:The findings of the present study indicated that IVM had similar clinical effects compared with IVF in patients with PCOS. However, IVM might be a suitable option for PCOS in terms of cost and successful pregnancy rate.

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Hashimoto’s thyroiditis might increase polycystic ovary syndrome and associated comorbidities risks in Asia

Cited by 10 publications

References 32 publications

The prevalence of polycystic ovarian syndrome in Chinese women: a meta-analysis

The prevalence of polycystic ovarian syndrome in Chinese women: a meta-analysis

Vitamin D improves levels of hormonal, oxidative stress and inflammatory parameters in polycystic ovary syndrome: a meta-analysis study

Comparison of in vitro maturation and in vitro fertilization for polycystic ovary syndrome patients: a systematic review and meta-analysis

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