Hashimoto’s thyroiditis in papillary thyroid carcinoma: a 22-year study

Hanege, Fatih Mehmet; Tüysüz, Ozan; Çelik, Serdal; Sakallıoğlu, Öner; Solmaz, Özgen Arslan

doi:10.14639/0392-100x-n1081

Cited by 20 publications

(17 citation statements)

References 20 publications

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“…In recent years, the incidence of PTC with HT is increasing [1,2,3] . An epidemiological study reported that PTC co-existed with PTC on average about 23% [9] , and in this study, this value was higher. The exact relationship between them has not been elucidated, but some studies have suggested that they have same immune link and same gene expression, and patients with HT have a higher risk of PTC [6,7,10,11] .Ultrasonography is one of the most important methods to diagnose thyroid diseases at present, including conventional two-dimensional ultrasound, Doppler ultrasound, shear wave elastography, superb micro-vascular imaging and contrast-enhanced ultrasound.…”

Section: Discussionsupporting

confidence: 42%

Ultrasonographic Characteristics Analysis of Papillary Thyroid Carcinoma with Hashimoto's Thyroiditis in Different Functional States

2022

IJFM

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The ultrasonographic characteristics of thyroid papillary carcinoma with and without hashimoto's thyroiditis were compared and analyzed to explore the effect of hashimoto's thyroiditis on ultrasonographic characteristics of thyroid papillary carcinoma, in order to improve the accuracy of ultrasonic diagnosis. Method 91 patients with thyroid papillary carcinoma confirmed by surgical resection and pathological biopsy in Beijing Chaoyang Hospital, Capital Medical University from September 2018 to November 2021 were retrospectively analyzed. Result The maximum diameter, blood flow grade and lymph node metastasis rate of papillary thyroid carcinoma in hashimoto's thyroiditis group were significantly higher than those in non-hashimoto thyroiditis group (P < 0.05). There were significant differences in the growth pattern, hardness and Ratio of papillary thyroid carcinoma among the three subgroups (P < 0.05). Conclusion Under different functional states, thyroid papillary carcinoma combined with hashimoto's thyroiditis showed differences in the growth pattern, hardness, blood grade and other sonographic characteristics.

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Section: Discussionsupporting

confidence: 42%

Ultrasonographic Characteristics Analysis of Papillary Thyroid Carcinoma with Hashimoto's Thyroiditis in Different Functional States

2022

IJFM

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“…They also warn against unnecessary lymph node dissections [38]. Hanege et al found an increased incidence of multifocality in HT patients and therefore suggest surgical intervention that considers this risk [21].…”

Section: Protective Effects Of Hashimoto's Thyroiditis On Papillary T...mentioning

confidence: 99%

Hashimoto’s Thyroiditis Effects on Papillary Thyroid Carcinoma Outcomes: A Systematic Review

Osborne¹,

Choudhary²,

Vyas³

et al. 2022

Cureus

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Papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT), also known as chronic lymphocytic thyroiditis, are both common thyroid diseases that are increasing in prevalence. PTC is well-differentiated cancer that generally has an excellent prognosis. HT is an autoimmune disease that often leads to hypothyroidism. A significant proportion of PTC patients also have HT. This systematic review will analyze the effect of HT on the characteristics and outcomes of PTC.Several databases were systematically searched using relevant medical subject headings (MeSH) keywords and phrases examining the connection between PTC and HT and the effect of their coexistence. Inclusion and exclusion criteria were applied, followed by quality appraisal. After that filtration process, 23 articles were selected with a total of 41,646 patients.Out of 22 studies commenting on tumor size, 12 studies demonstrated it to be smaller in HT patients, while 10 studies observed no effect. Eleven studies examined PTC angioinvasion, most of which found no difference in HT and non-HT patients. However, two studies found angioinvasion to be reduced in PTC patients. As for capsular infiltration, out of the five studies commenting on it, two found decreased occurrence, one found increased occurrence, and two had no difference. Extrathyroidal extension was found to be reduced in seven studies out of the 14 that examined it. Six other studies saw no effect. One study found increased extrathyroidal extension incidence overall, and another found it to be the case in patients younger than 45 years of age. Lymph node metastases were found to be reduced in several studies, while others found no difference. One study found increased central lymph node metastases in HT patients. As for prognoses, most studies found positive aspects. One study found an increased recurrence rate in HT patients, however, it did not have a relationship with deaths.In conclusion, when managing HT or HT and PTC patients, HT patients should be monitored closely for suspicious nodules due to their frequent co-occurrence. Although the effect of HT on PTC has been shown to be mostly protective, multifocality is more common in those patients and, therefore, a total thyroidectomy should be favored. The high false positive rates of lymph node metastases in diagnostic methods should be kept in mind when considering lymph node dissection. Additional diagnostic procedures such as frozen section histology should be considered for verification.

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“…In the subgroup of patients with HT, the NAFLD group had a significantly higher incidence of multifocal lesions than the non-NAFLD group. Several studies have verified that patients with HT, who develop PTC, have an increased risk of having multifocal tumors [ 28 , 29 ]. Our results suggested that the occurrence of NAFLD and HT together increases the incidence of multifocal tumors; however, further studies are required to confirm this pattern.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and impact of non-alcoholic fatty liver disease in patients with papillary thyroid carcinoma

Xiao

Cai

et al. 2023

Endocrine

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Purpose Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. Non-alcoholic Fatty Liver Disease (NAFLD) was possibly among the risk factors for thyroid carcinoma. It is uncertain whether NAFLD is associated with the aggressiveness of PTC. Methods We obtained data on patients with PTC who had undergone surgery at the First Affiliated Hospital of Wenzhou Medical University between January 2020 and February 2022. Pre-and post-operative data were obtained from electronic medical records and analyzed. Patients were split into two groups based on the NAFLD diagnostic criteria and compared using univariate and multivariate analysis through a logistic regression model. Results In all, 3468 patients with PTC were included in this study, of which 594 (17.1%) were diagnosed with NAFLD. NAFLD was found to be an independent risk factor for lymph node metastasis ( OR = 1.285 95% CI: 1.052–1.570), incidence of BRAF V600E mutation ( OR = 1.504, 95% CI: 1.148–1.972) and later tumor stage at diagnosis ( OR = 2.310, 95% CI: 1.700–3.139) in PTC. The association mentioned above remained significant in subgroups of patients with Hashimoto’s thyroiditis (HT), hypertension, diabetes (DM), high triglyceride (TG) levels, low levels of high-density lipoprotein-cholesterol (HDL-C), and high body mass index (BMI). In subgroup of female rather than male, NAFLD was an independent risk factor for lymph node metastasis ( OR = 1.638 95% CI: 1.264–2.123), incidence of BRAF V600E mutation ( OR = 1.973, 95% CI: 1.368–2.846) as well as later tumor stage ( OR = 2.825, 95% CI: 1.964–4.063) in PTC. However, NAFLD was not a risk factor for the larger tumor size (>1 cm), extra-thyroidal extension (ETE), or multifocality in PTC. Conclusion Our cross-sectional study indicated that there is a strong association of NAFLD with higher incidence of lymph node metastasis, higher incidence of BRAF V600E mutation and later TNM stage than non-NAFLD in females with PTC.

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Hashimoto’s thyroiditis in papillary thyroid carcinoma: a 22-year study

Cited by 20 publications

References 20 publications

Ultrasonographic Characteristics Analysis of Papillary Thyroid Carcinoma with Hashimoto's Thyroiditis in Different Functional States

Ultrasonographic Characteristics Analysis of Papillary Thyroid Carcinoma with Hashimoto's Thyroiditis in Different Functional States

Hashimoto’s Thyroiditis Effects on Papillary Thyroid Carcinoma Outcomes: A Systematic Review

Prevalence and impact of non-alcoholic fatty liver disease in patients with papillary thyroid carcinoma

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