Hashimoto’s Thyroiditis

Parvathaneni, Arvin; Fischman, Daniel; Cheriyath, Pramil

doi:10.5772/30288

Cited by 7 publications

(4 citation statements)

References 62 publications

(55 reference statements)

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“…So the calcium homeostasis is affected leading to decreased calcium levels in the blood. Blair A. Wormer et al in their study had 38% transient hypocalcaemia, without any RLN palsy or hypoparathyroidism [29].…”

Section: Occurrence Of Transient Hypocalcemiamentioning

confidence: 86%

Role of Total Thyroidectomy in Painful (Symptomatic) Hashimoto’s Thyroiditis: Descriptive Study

Bage

Kalatharan

2020

Indian J Otolaryngol Head Neck Surg

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Hakura Hashimoto described Hashimoto’s Thyroiditis (HT) in 1912. In HT, there occurs formation of antibodies against the self (thyroid), which causes enlargement of the thyroid gland as a whole and decreased thyroid hormone levels. Most of the patients with HT are given medical line of management (hypo/hyperthyroidism). The indications for surgical line of management for HT are due to pressure symptoms over the trachea and oesophagus, pain in the thyroid gland and for chance of malignancy. Surgical treatment gives complete relief from pain and pressure symptoms and also prevents the risk of malignancy. To evaluate the outcome and complications of total thyroidectomy in painful (symptomatic) Hashimoto’s thyroiditis. It was a Hospital based Descriptive study conducted in tertiary care teaching hospital by ENT Department, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry from Nov 2017 to May 2019. Sample size was 30. All patients with symptomatic (painful) HT was given trail of medical therapy (steroids and NSAIDS), following repeated attempts of failed medical therapy, surgical management (total thyroidectomy) was preferred. Visual Analog Scale (VAS) was used to assess the pain grading pre and post operatively. MS Excel and SPSS trial version 20 software was used to analyze the data. The Wilcoxan Signed Ranked test was used as test of significance to identify the difference between ordinal variables. In this study, all the 30 patients had pain as the predominant symptom. Visual Analog Scale was used to grade the pain in all the patients preoperatively and 2 weeks postoperatively. All the patients had significant reduction in the pain following total thyroidectomy, when compared to pre-operative VAS grading. Total thyroidectomy is the technique of choice in surgical treatment of symptomatic Hashimoto’s thyroiditis (pain, tenderness and pressure symptoms) which warrants a radical and definitive control of the disease, without any risk of relapse and without the side effects of medical management. Moreover in longstanding cases of HT, the risk of malignant transformation is prevented due to total thyroidectomy. In experienced hands it assures total relief of compressive and painful symptoms and low incidence of/nil major complications.

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Section: Occurrence Of Transient Hypocalcemiamentioning

confidence: 86%

Role of Total Thyroidectomy in Painful (Symptomatic) Hashimoto’s Thyroiditis: Descriptive Study

Bage

Kalatharan

2020

Indian J Otolaryngol Head Neck Surg

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“…12 A small group of patients, with Hashimoto's thyroiditis, present with pain and tenderness and thyroidectomy has been proven to be effective. 13 Thyroidectomy has become a safe operation with little risk of mortality and long term morbidity. With meticulous operative technique and careful attention to detail, injury to the recurrent laryngeal nerves and superior laryngeal nerves and permanent hypoparathyroidism can be minimized.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of postoperative hypocalcaemia following total thyroidectomy in patients with Hashimoto’s thyroiditis and multinodular goitre in a rural tertiary care hospital

Amrutha¹,

Joseph²,

Mathew³

et al. 2020

Int Surg J

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Background: Recurrent laryngeal nerve injury, hypothyroidism and hypocalcaemia have long been recognized as the three main sequalae of thyroidectomy. Persistent hypocalcaemia may cause intracranial lesions and cardiac arrhythmias. As the definitive diagnosis of Hashimoto’s thyroiditis was not always possible with clinical and cytological parameters when antibody testing was not done, surgery was planned with the diagnosis of multinodular goitre. This study was conducted to find out the incidence of post-operative hypocalcaemia following total thyroidectomy by skilled surgeons in patients with multinodular goitre and Hashimoto’s thyroiditis.Methods: This was a cross-sectional study to compare the incidence of hypocalcaemia in patients with biopsy-proven Hashimoto’s thyroiditis and multinodular goitre. After obtaining approval from the institutional review board and ethics committee, data was collected serially, from the surgical records of 123 patients who underwent total thyroidectomy in this tertiary care centre, during the past two years.Results: The incidence of post-operative hypocalcaemia (71.1%) in patients undergoing total thyroidectomy with Hashimoto’s thyroiditis was significantly higher than in patients with multinodular goitre (56.4%). Of the 45 patients who had a biopsy report of Hashimoto’s thyroiditis, 8 (17.8 %) developed permanent hypocalcaemia while only 8 (10.3%) of the 78 patients with histopathological diagnosis of multinodular goitre developed persistent hypocalcaemia needing supplementation following total thyroidectomy in this rural tertiary care hospital.Conclusions: The significant risk of post-operative hypocalcaemia should be kept in mind before opting for total thyroidectomy for benign lesions of the thyroid and pre-operative antibody studies must be done to diagnose Hashimoto’s thyroiditis.

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“…The anatomical properties of the gland are revealed by ultrasonography, which also reveals any significant alterations to the gland. Ultrasonography can assist distinguish Hashimoto's thyroiditis in goitres with unclear causes, and it can also help determine the reason for functional impairment and the need for treatment [54,55]. An accurate diagnosis of the condition is frequently made using the thyroid glands morphological characteristics, serum TSH levels, serum antithyroid antiglobulin titers, radioactive iodine uptake of the gland, and reaction to the perchlorate discharge test.…”

Section: Pathophysiologymentioning

confidence: 99%

General overview of the Risk factors, Pathogenesis, and Combined treatments for Hashimoto's Thyroiditis (HT)

Srivastav,

Prajapati,

Meera

et al. 2023

World Journal of Current Med and Pharm Research

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In regions of the world where iodine is abundant, Hashimoto's thyroiditis, also known as Hashimoto's disease or autoimmune thyroiditis, is the most prevalent cause of hypothyroidism. It is a chronic inflammation of the thyroid gland. It is characterized by autoimmune-mediated thyroid gland destruction, which results in progressive thyroid failure, either with or without goiter formation. In young to middle-aged women, Hashimoto's thyroiditis typically starts as a painless, diffuse, firm thyroid gland enlargement that progresses to hypothyroidism. Many people don't initially exhibit hypothyroidism, and some don't even have a goiter or may have an atrophic thyroid gland. Hashimoto's thyroiditis (HT), also known as chronic autoimmune thyroiditis, is an inflammatory condition that is characterized by parenchymal atrophy, fibrosis, and diffuse lymphocytic infiltration. being the main source of primary hypothyroidism in regions with adequate iodine. With the help of various criteria, such as physical examination, blood tests for thyroid hormone levels (TSH is low, T3 and T4 are tall, for example), serum cholesterol and triglycerides, blood glucose, and radioactive iodine uptake, it is possible to distinguish between infections and clutter. According to estimates from several thyroid disease studies, 42 million persons in India are estimated to have the ailment. The pathogenesis causes, risk factors and combination therapy linked to Hashimoto's thyroiditis are discussed in this review study.

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Hashimoto’s Thyroiditis

Cited by 7 publications

References 62 publications

Role of Total Thyroidectomy in Painful (Symptomatic) Hashimoto’s Thyroiditis: Descriptive Study

Role of Total Thyroidectomy in Painful (Symptomatic) Hashimoto’s Thyroiditis: Descriptive Study

A comparative study of postoperative hypocalcaemia following total thyroidectomy in patients with Hashimoto’s thyroiditis and multinodular goitre in a rural tertiary care hospital

General overview of the Risk factors, Pathogenesis, and Combined treatments for Hashimoto's Thyroiditis (HT)

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