Hashimoto's Struma Lymphomatosa Diagnostic Value and Significance of Serum-Flocculation Reactions

Luxton, R.W.; Cooke, R. T.

doi:10.1016/s0140-6736(56)90860-1

Cited by 68 publications

(7 citation statements)

References 3 publications

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“…Hashimoto's disease has been shown in patients with liver disease (Luxton and Cooke, 1956;McConkey and Callaghan, 1960). In our series, one of the two patients with this combination has been reported previously (McConkey and Callaghan, 1960).…”

Section: Prognosissupporting

confidence: 51%

Active `juvenile' cirrhosis considered as part of a systemic disease and the effect of corticosteroid therapy

Read¹,

Sherlock²,

Harrison³

1963

Gut

202

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EDITORIAL SYNOPSIS This is a clinical study of 81 patients (32 male and 49 female), who are not alcoholics, with jaundice of hepato-cellular type lasting longer than three months. Forty-nine of these patients were under 21 years of age. The natural history of the condition and the response to corticosteroid therapy is described; good symptomatic relief can be achieved with corticosteroids but they do not seem to prolong life. The aetiology is discussed with special reference to the relationship to viral hepatitis, to systemic lupus erythematosus, and to other disturbances of immunity.

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Section: Prognosissupporting

confidence: 51%

Active `juvenile' cirrhosis considered as part of a systemic disease and the effect of corticosteroid therapy

Read¹,

Sherlock²,

Harrison³

1963

Gut

202

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“…Chronic lymphocytic thyroiditis was one of the common autoimmune disorders and clinically received attention because of the high incidence of complication by other autoimmune disorders. There were several reports concerning the relationship between liver and the thyroid gland (McConkey and Collaghan, 1960;Luxton and Cooke, 1956;Roitt and Doniach, 1958). McConkey and Collaghan (1960) speculated that chronic liver disease accompanied by chronic lymphocytic thyroiditis resulted from an autoimmune process.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it is important to examine the incidence of AAT in danger of potentially progressing to overt hypothyroidism. It has been known that hepatic dysfunction is found in some cases of Hashimoto's thyroiditis (McConkey and Collaghan, 1960;Luxton and Cooke, 1956;Roitt and Doniach, 1958). As reported by McConkey and Collaghan (1960), an autoimmune process similar to Hashimoto's thyroiditis might cause hepatic dysfunction.…”

Section: Endocrinolmentioning

confidence: 99%

Thyroid antibodies in healthy blood donors.

et al. 1984

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The frequency of thyroid antibodies was investigated in 1314 healthy blood donors. Twenty-three of 870 males (2.6%) were positive for thyroglobulin antibody (TA), 34 (3.9%) for thyroid microsomal antibody (MA) and 19 (2.2%) for both TA and MA. Thirty-four of 484 females (6.2%) were positive for TA, 46 (9.5%) for MA and 29 (6.0%) for both TA and MA. Eighty-six of 1314 blood donors were positive for TA and/or MA. There was no difference in liver function tests between AAT and controls. In females, the incidence of thyroid antibodies tended to increase with age. However, the subjects aged under 19 showed another peak of incidence of thyroid antibodies. The values of total T4, T3 and free T4 were not different between 86 subjects with positive thyroid antibodies (asymptomatic autoimmune thyroiditis, AAT) and 86 sex- and age-matched controls without thyroid antibodies, whereas serum TSH of AAT was significantly higher than that of controls. Nine of 86 (10.5%) subjects with AAT had apparently increased basal TSH level.

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“…Four patients with Hashimoto's disease were found to have significantly elevated values for serum gamma globulin. Others have since noted this electrophoretic change, and also that results of the "colloidal gold," "thymol turbidity" and "cephalin flocculation" tests frequently were positive in the presence of this disease (17)(18)(19)(20).…”

mentioning

confidence: 94%

“…In Gajdusek's thorough analysis (44) of possible auto-immune diseases, 1 patient each with "lupoid" hepatitis, chronic biliary cirrhosis, disseminated lupus erythematosus, and macroglobulinemia exhibited high complementfixing titers to thyroid extracts; these were exceptional, however. Autoimmune diseases of other organs may be associated with similar thyroidal diseases-liver (19), kidney (45), adrenal glands (46) and Paget's disease of bone (45,47). It is apparent that the immunologic dogma of "horror autotoxicus" is undergoing thorough scrutiny.…”

mentioning

confidence: 99%

A Review of “Auto-Immunization” in Hashimoto–s Disease

Owen

1958

The Journal of Clinical Endocrinology & Metabolism

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Hashimoto's Struma Lymphomatosa Diagnostic Value and Significance of Serum-Flocculation Reactions

Cited by 68 publications

References 3 publications

Active `juvenile' cirrhosis considered as part of a systemic disease and the effect of corticosteroid therapy

Active `juvenile' cirrhosis considered as part of a systemic disease and the effect of corticosteroid therapy

Thyroid antibodies in healthy blood donors.

A Review of “Auto-Immunization” in Hashimoto–s Disease

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