Has the shortage of fludarabine altered the current paradigm of lymphodepletion in favor of bendamustine?
Dimitrios Filioglou,
Muhammad Husnain,
Sharad Khurana
et al.
Abstract:The most common lymphodepletion regimen used prior to infusion of chimeric antigen receptor-T cells (CAR-T) is cyclophosphamide (CY) in combination with fludarabine (Flu) (CY-FLU). While cyclophosphamide (CY) possesses lymphotoxic effects, it concurrently preserves regulatory T cell activity, potentially affecting the efficacy of CAR-T cells. Moreover, the use of fludarabine (FLU) has been linked to neurotoxicity, which could complicate the early detection of immune effector cell-associated neurotoxicity syndr… Show more
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