Has-miR-146a polymorphism (rs2910164) and cancer risk: a meta-analysis of 19 case–control studies

Wang, Jun; Bi, Jian; Liu, Xin; Li, Kainan; Jiang, Di; Wang, Baocheng

doi:10.1007/s11033-011-1247-7

Cited by 64 publications

(43 citation statements)

References 36 publications

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“…of human genome [10]. Recently, various studies focused on the pre-miRNA polymorphisms located on the stem-loop, such as pre-mir-196a2 rs11614913 [20], pre-mir-146a rs2910164 [21], pre-mir-499 rs3746444 [22,23]. In the present study, the G allele of pre-let7d rs10993081 was found to contribute an independent increased risk for MetS and this association may be partially due to its effect on glucose metabolism.…”

Section: Fig 3 Interaction Dendrogramsupporting

confidence: 53%

Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population

Yan

Zhang

et al. 2015

Endocr J

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MicroRNA (miRNA) related genetic variation may change miRNA binding affinity and mRNA expression levels of the target genes, thus leading to altered metabolic parameters. This study explored the influence of let-7 related single nucleotide polymorphisms (SNPs) on individual susceptibility to metabolic syndrome (MetS) in a Chinese population. Seven SNPs located at the pri-let-7 gene region, pre-let-7 gene region or 3’-UTR of the KRAS gene were selected. The SNPs were genotyped in 503 MetS patients and 529 normal controls using the high-throughput Sequenom genotyping platform. Unconditional logistic regression analysis was utilized to estimate the association between these SNPs and the risk of MetS. There are three SNPs significantly associated with MetS. The A allele of rs17276588 was associated with an increased risk effect for MetS (Adjusted OR=1.75, 95%CI 1.37-2.25,

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Section: Fig 3 Interaction Dendrogramsupporting

confidence: 53%

Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population

Yan

Zhang

et al. 2015

Endocr J

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“…A previous experimental study indicated that MiRNA has a key influence on tumor biology and is related to the progression and prognosis of cancer, and that the high expression of miR-499A>G in serum was significantly associated with a longer survival of non-small cell lung cancer (Hu et al, 2010;Liu et al, 2011). Common single nucleotide polymorphisms in premiRNA, rs3746444 in miR-499A>G and rs2910164 in miR-146aG>C, have been studied in various cancers, such as breast cancer, gastric cancer, cervical squamous cell cancer and colorectal cancer (Catucci et al, 2010;Okubo et al, 2010;Gao et al, 2011;Zhou et al, 2011;Srivastava and Srivastava, 2012;Wang et al, 2012). However, the results of these studies were inconsistent.…”

Section: Introductionmentioning

confidence: 99%

miR-499A>G rs3746444 and miR-146aG>C expression and hepatocellular carcinoma risk in the Chinese population

Shan¹,

Huang²,

Chen³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study of a possible association of miR-499A>G rs3746444 and miR-146aG>C rs2910164 with risk of hepatocellular carcinoma. Samples from 172 hepatocellular carcinoma patients and 185 cancer-free controls were collected from October 2008 to December 2011. PCR-RFLP analysis was performed to determine the polymorphisms in each individual. The MAFs of miR-146aG>C and miR-499A>G in controls were similar to that known from the SNP database, and frequencies of genotypes in controls were in line with Hardy-Weinberg equilibrium. We found that miR-499 AG was significantly associated with decreased risk for hepatocellular carcinoma when compared with miR-499 AA genotype (adjusted odds ration = 0.74, 95% confidence interval = 0.24-0.96). However, subjects carrying miR-146a GG had a nonsignificant 0.62-fold decreased risk of hepatocellular carcinoma. We did not find a significant association of miR-146aG>C rs2910164 and miR-499A>G rs3746444 polymorphisms with hepatocellular carcinoma risk in the Chinese population. Further investigations are warranted to clarify the relationship between miRNA polymorphisms and susceptibility to hepatocellular carcinoma risk in various ethnic populations.

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“…However, association studies with small sample sizes lack statistical power and may produce conflicting conclusions. During the preparation of this manuscript, several metaanalyses concerning rs2910164 polymorphism and cancer risk were published (Gao et al, 2011;Qiu et al, 2011;Xu et al, 2011;Wang et al, 2012). However, these studies have not addressed the interaction of compounding factors.…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis confirms that a common G/C variant in the pre-miR-146a gene contributes to cancer susceptibility and that ethnicity, gender and smoking status are risk factors

Wang¹,

Xu²,

Tong³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. Evidence has shown that miR-146a is involved in carcinogenesis, and a common G/C variant (rs2910164) in the premiR-146a gene has been associated with various types of cancer. We summarized the data from 22 published case-control studies on the association between rs2910164 and cancer risk and performed subgroup analyses by ethnicity, gender and smoking status. We found a significant association between the pre-miR-146a polymorphism and cancer risk in Caucasian populations (odds ratio (OR) = 0.93, 95% confidence interval (CI) = 0.88-0.99 for G-vs C-allele), while the significance was borderline in Asian populations (OR = 1.11, 95%CI = 1.00-1.23 for G-vs C-allele). A significantly increased risk of cancer was found in males with GG/GC genotypes (OR = 1.23, 95%CI = 1.10-1.37), and the significance was more pronounced in smokers (OR = 1.82, 95%CI = 1.32-2.51) than in non-smokers (OR = 1.24, 95%CI = 1.01-1.53). We conclude that there is evidence that the pre-miR-146a polymorphism contributes to cancer susceptibilities and that gender and smoking status affect the probability of cancer in individuals with this polymorphism.

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Has-miR-146a polymorphism (rs2910164) and cancer risk: a meta-analysis of 19 case–control studies

Cited by 64 publications

References 36 publications

Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population

Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population

miR-499A>G rs3746444 and miR-146aG>C expression and hepatocellular carcinoma risk in the Chinese population

Meta-analysis confirms that a common G/C variant in the pre-miR-146a gene contributes to cancer susceptibility and that ethnicity, gender and smoking status are risk factors

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