Has COVID-19 Modified the Weight of Known Systemic Inflammation Indexes and the New Ones (MCVL and IIC) in the Assessment as Predictive Factors of Complications and Mortality in Acute Pancreatitis?

Rădulescu, P; Davițoiu, Dragoș Virgil; Bãleanu, Vlad Dumitru; Pădureanu, Vlad; Ramboiu, Dumitru Sandu; Șurlin, Valeriu; Bratiloveanu, Tudor Constantin; Georgescu, E; Streba, Costin Teodor; Mercuţ, Răzvan; Căluianu, Elena Irina; Traşcă, E; Rădulescu, D

doi:10.3390/diagnostics12123118

Cited by 7 publications

(16 citation statements)

References 68 publications

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“…During the global chaos of the first wave of COVID-19, the outcomes of acute abdominal pathology were negatively affected ( 6 ) and millions of elective surgical procedures were canceled ( 68 ). This move allowed the redistribution of resources and healthcare personnel towards the additional care needs of patients with COVID-19.…”

Section: Surgical Therapeutic Protocolmentioning

confidence: 99%

“…for trauma presentations (5,6). Based on these concerns, the present study formulated the following research questions: Has the COVID-19 infection affected the number of patients presenting to the hospital with trauma?…”

Section: Effect Of the Covid-19 Pandemic On The Management And Outcom...mentioning

confidence: 99%

“…The arguments for redistribution were driven by contextual policies to halt the spread of the virus and ultimately by reduced trauma presentations. However, medical professionals have expressed concern about the impact of COVID-19 on healthcare systems, particularly in terms of providing emergency medical services for trauma presentations ( 5 , 6 ). Based on these concerns, the present study formulated the following research questions: Has the COVID-19 infection affected the number of patients presenting to the hospital with trauma?…”

Section: Introductionmentioning

confidence: 99%

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Effect of the COVID‑19 pandemic on the management and outcomes of patients with traumatic injuries (Review)

Boldea,

Caragea,

Nicolcescu

et al. 2023

Biomed Rep

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During the COVID-19 pandemic, ~10% of the global population was officially affected, resulting in diverse changes, ranging from shopping habits to stringent hospital protocols. This article sought to provide a concise summary of relevant data concerning the interplay between COVID-19 and trauma, encompassing the entire trajectory from presentation to hospital discharge. Throughout the pandemic, there was a noticeable reduction in trauma presentations, while the ranking of injury mechanisms remained largely unchanged. To ensure essential surgical support, protocols were adjusted accordingly. Although there were some less significant changes in injury severity score, hospital length of stay, intensive care unit stay and mortality, the overall patient outcomes appeared to improve. In conclusion, the COVID-19 pandemic led to a decline in trauma cases and an enhancement in patient outcomes. However, regrettably, certain mechanisms of injury saw an increase in frequency. To cope with the epidemiological context, management strategies were adapted, and unutilized resources were redirected to cater to the care of COVID-19 patients.

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Section: Surgical Therapeutic Protocolmentioning

confidence: 99%

Section: Effect Of the Covid-19 Pandemic On The Management And Outcom...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of the COVID‑19 pandemic on the management and outcomes of patients with traumatic injuries (Review)

Boldea,

Caragea,

Nicolcescu

et al. 2023

Biomed Rep

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“…Radulescu et al [50] were the first to have highlighted new hematological indices calculated according to the increased values of the red cell distribution width (RDW), and the mean corpuscular volume (MCV), and they obtained the ratio between the mean corpuscular volume and lymphocytes (MCVL), and the cumulative inflammatory index (IIC) ((mean corpuscular volume × width of erythrocyte distribution × neutrophils)/(lymphocytes × 1000)). These new hematological indices better reflect the inflammation-induced changes to red and white cells in the peripheral blood following an inflammatory process.…”

Section: Introductionmentioning

confidence: 99%

Interrelation of Hypoxia-Inducible Factor-1 Alpha (HIF-1 α) and the Ratio between the Mean Corpuscular Volume/Lymphocytes (MCVL) and the Cumulative Inflammatory Index (IIC) in Ulcerative Colitis

Poenariu,

Boldeanu,

Ungureanu

et al. 2023

Biomedicines

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We intended to investigate the presence and medical application of serum hypoxia-inducible factor-1 alpha (HIF-1α) along with the already known systemic inflammatory markers and the new one’s inflammatory indices, the proportion of mean corpuscular volume and lymphocytes (MCVL) and the cumulative inflammatory index (IIC), for patients with ulcerative colitis (UC). We sought to establish correlations that may be present between the serum levels of HIF-1α and these inflammatory indices, as well as their relationship with disease activity and the extent of UC, which can provide us with a more precise understanding of the evolution, prognosis, and future well-being of patients. Serum samples were collected from 46 patients diagnosed with UC and 23 controls. For our assessment of the serum levels of HIF-1α, we used the Enzyme-Linked Immunosorbent Assay (ELISA) technique. Thus, for HIF-1α we detected significantly higher values in more severe and more extensive UC. When it came to MCVL and IIC, we observed statistically significant differences between the three groups being compared (Severe, Moderate, and Mild). Our study highlighted that HIF-1α correlated much better with a disease activity score, MCVL, and IIC. With MCVL and IIC, a strong and very strong correlation had formed between them and well-known inflammation indices. By examining the ROC curves of the analyzed parameters, we recognized that TWI (accuracy of 83.70%) provides the best discrimination of patients with early forms of UC, followed by HIF-1α (73.90% accuracy), MCVL (70.90% accuracy), and PLR (70.40%). In our study, we observed that HIF-1α, MCVL, and PLR had the same sensitivity (73.33%) but HIF-1α had a much better specificity (60.87% vs. 58.70%, and 54.35%). Also, in addition to the PLR, HIF-1α and MCVL can be used as independent predictor factors in the discrimination of patients with early forms of UC.

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“…The documentation by Wang et al25 first highlighted the possible harm inflicted on the pancreas by COVID-19. Subsequently, other case reports and retrospective investigations have emerged, indicating a plausible correlation between COVID-19 and pancreatitis, particularly AP.According to retrospective research conducted in Romania, it was shown that SARS-CoV-2 infection had a significant impact on the relative risk of mortality in patients with AP 26. In cohort research using the Hong Kong Hospital Authority and the UK Biobank database, Lin et al27 also documented pancreatitis as a persistent acute consequence of COVID-19 infection.…”

mentioning

confidence: 99%

Eliminating COVID‐19 as the immediate culprit for igniting pancreatitis

Ge,

Luo,

Liu

et al. 2023

Journal of Medical Virology

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The impact of severe acute respiratory syndrome coronavirus 2 infection on the potential development of pancreatitis is a subject of ongoing debate within academic discourse. Establishing a causal link between COVID‐19 and pancreatitis may not be fully supported by relying only on retrospective studies or case reports. This study examined the relationship between COVID‐19 phenotypes and pancreatitis by Mendelian randomization (MR) method. The identification of instrumental variables (single nucleotide polymorphisms) that exhibit a robust association with the COVID‐19 phenotypes was accomplished through a meticulous process of rigorous screening procedures. We included acute pancreatitis and chronic pancreatitis (CP) as the outcomes in the MR analysis, even though no definitive studies exist between COVID‐19 and CP. A direct causal relationship between genetically predicted COVID‐19 phenotypes and pancreatitis risk cannot be established. There is an ongoing debate over the designation of COVID‐19 as a definitive cause of pancreatitis.

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Has COVID-19 Modified the Weight of Known Systemic Inflammation Indexes and the New Ones (MCVL and IIC) in the Assessment as Predictive Factors of Complications and Mortality in Acute Pancreatitis?

Cited by 7 publications

References 68 publications

Effect of the COVID‑19 pandemic on the management and outcomes of patients with traumatic injuries (Review)

Effect of the COVID‑19 pandemic on the management and outcomes of patients with traumatic injuries (Review)

Interrelation of Hypoxia-Inducible Factor-1 Alpha (HIF-1 α) and the Ratio between the Mean Corpuscular Volume/Lymphocytes (MCVL) and the Cumulative Inflammatory Index (IIC) in Ulcerative Colitis

Eliminating COVID‐19 as the immediate culprit for igniting pancreatitis

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