Besides oilseed rape and soybean, sunflower is one of the most important annual oilcrops. Apart from seed yield, which is the most important trait in many crops, oil yield is of utmost interest for sunflower breeders and farmers. Compared to the seed yield of sunflowers, their total biomass is often very high, and it is of great agronomic interest to increase the ratio of both parameters, which is defined as harvest index. With an increase in harvest index, improvements of resource‐use efficiencies can be expected. To generate an adequate seed yield, water and nutrients are key factors and their efficient use becomes increasingly important under conditions of aridity and higher production goals. A pot experiment was conducted in summer 2017 to determine differences in harvest index of various sunflower genotypes which could have an influence on the use efficiencies of water and nutrients (N, P, K). In total, 25 genotypes of different origin and with various morphological traits were investigated under optimal growth conditions. The harvest index varied from 29% to 47% and showed significant differences among some genotypes. The harvest index was less affected by the total biomass of the plants but more by the seed yield. The seed yield itself was mainly determined by the single seed weight rather than by the number of seeds. The experiment also confirmed significant positive correlations between harvest indices and all use efficiencies. Genotypes with high harvest indices were characterized by high oil concentrations in the seeds and particularly by high oil yields. In conclusion, cultivation of sunflower genotypes with high harvest indices most likely results in high water‐use efficiency and high nutrient‐utilization efficiencies as well as in high oil yields.