Indigenous scholars and their allies increasingly contribute to food systems debates and practices through pursuing and interrogating ideas of Indigenous food sovereignty. This essay adds to this ongoing conversation by providing a synthesis of and reflection on a panel session on Indigenous food sovereignty held at the American Association of Geographers (AAG) 2022 Annual Meeting. We place this conversation in the context of a growing body of scholarship on food sovereignty and Indigenous food systems. Organized by the AAG’s Geographies of Food and Agriculture Specialty Group, with support from the Journal of Agriculture, Food Systems and Community Development, the session engaged Indigenous scholars in a discussion about the meaning of food sovereignty, different ways of knowing, relationships and reciprocity, and systems of power. The panelists emphasized the relationship between all elements of creation at the core of food sovereignty, the importance of valuing different ways of knowing and expertise, making visible histories of settler knowledge appropriation, and critically assessing how power manifests, operates, and is understood in different food systems and worldviews. Building on the scholarly literature and the evolving place-based grounding of food sovereignty movements, we argue that it is critical to address ongoing realities of genocide and settler colonialism in North America/Turtle Island by forging respectful relationships with all of creation and to work through collaborations led by Indigenous people and grounded in reciprocity.