Harpagide: Occurrence in plants and biological activities - A review

Frezza, Claudio; Vita, Daniela De; Toniolo, Chiara; Ventrone, Antonio; Tomassini, Lamberto; Foddai, Sebastiano; Nicoletti, Marcello; Guiso, Marcella; Bianco, Armandodoriano; Serafini, Mauro

doi:10.1016/j.fitote.2020.104764

Cited by 13 publications

(8 citation statements)

References 158 publications

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“…A comparison of these results with those obtained using high-performance liquid chromatography analysis showed a similar level of DA detected from N2a cells, which is 4.9 ± 0.5 pM . Further experiments containing either harpagide, a natural product known to promote synaptic DA release, , or 6-hydroxydopamine (6-OHDA), , a neurotoxicant that is detrimental to dopaminergic neurons, were performed to verify the capacity of N7-P for detecting DA released from cells under these treatments. We treated N2a cells with either harpagide or 6-OHDA and used N7-P integrated biosensor to measure corresponding DA levels (Supporting Information 1.6 and).…”

Section: Resultsmentioning

confidence: 65%

Microfluidic Biosensor Decorated with an Indium Phosphate Nanointerface for Attomolar Dopamine Detection

et al. 2023

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Developing functional materials that directly integrate into miniaturized devices for sensing applications is essential for constructing the next-generation point-of-care system. Although crystalline structure materials such as metal organic frameworks are attractive materials exhibiting promising potential for biosensing, their integration into miniaturized devices is limited. Dopamine (DA) is a major neurotransmitter released by dopaminergic neurons and has huge implications in neurodegenerative diseases. Integrated microfluidic biosensors capable of sensitive monitoring of DA from mass-limited samples is thus of significant importance. In this study, we developed and systematically characterized a microfluidic biosensor functionalized with the hybrid material composed of indium phosphate and polyaniline nanointerfaces for DA detection. Under the flowing operation, this biosensor displays a linear dynamic sensing range going from 10 −18 to 10 −11 M and a limit of detection (LOD) value of 1.83 × 10 −19 M. In addition to the high sensitivity, this microfluidic sensor showed good selectivity toward DA and high stability (>1000 cycles). Further, the reliability and practical utility of the microfluidic biosensor were demonstrated using the neuro-2A cells treated with the activator, promoter, and inhibiter. These promising results underscore the importance and potential of microfluidic biosensors integrated with hybrid materials as advanced biosensors systems.

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Section: Resultsmentioning

confidence: 65%

Microfluidic Biosensor Decorated with an Indium Phosphate Nanointerface for Attomolar Dopamine Detection

et al. 2023

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“…The chemical structures of these iridoid glycosides were elucidated using nuclear magnetic resonance (NMR) spectroscopy [ 59 ]. Studies have shown that H. procumbens root tuber extracts that inhibited inflammation and alleviated pain contained harpagide [ 60 ], harpagoside, 8-p-coumaroylharpagide and acteoside as the main bioactive compounds [ 30 , 34 ]. From these results, it was concluded that the efficacy of the extract is dependent on the presence of the active agents.…”

Section: Resultsmentioning

confidence: 99%

The Fight against Infection and Pain: Devil’s Claw (Harpagophytum procumbens) a Rich Source of Anti-Inflammatory Activity: 2011–2022

Gxaba

Manganyi

2022

Molecules

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Harpagophytum procumbens subsp. procumbens (Burch.) DC. ex Meisn. (Sesame seed Family—Pedaliaceae) is a popular medicinal plant known as Devil’s claw. It is predominantly distributed widely over southern Africa. Its impressive reputation is embedded in its traditional uses as an indigenous herbal plant for the treatment of menstrual problems, bitter tonic, inflammation febrifuge, syphilis or even loss of appetite. A number of bioactive compounds such as terpenoids, iridoid glycosides, glycosides, and acetylated phenolic compounds have been isolated. Harpagoside and harpagide, iridoid glycosides bioactive compounds have been reported in countless phytochemical studies as potential anti-inflammatory agents as well as pain relievers. In-depth studies have associated chronic inflammation with various diseases, such as Alzheimer’s disease, obesity, rheumatoid arthritis, type 2 diabetes, cancer, and cardiovascular and pulmonary diseases. In addition, 60% of chronic disorder fatalities are due to chronic inflammatory diseases worldwide. Inflammation and pain-related disorders have attracted significant attention as leading causes of global health challenges. Articles published from 2011 to the present were obtained and reviewed in-depth to determine valuable data findings as well as knowledge gaps. Various globally recognized scientific search engines/databases including Scopus, PubMed, Google Scholar, Web of Science, and ScienceDirect were utilized to collect information and deliver evidence. Based on the literature results, there was a dramatic decrease in the number of studies conducted on the anti-inflammatory and analgesic activity of Devil’s claw, thereby presenting a potential research gap. It is also evident that currently in vivo clinical studies are needed to validate the prior massive in vitro studies, therefore delivering an ideal anti-inflammatory and analgesic agent in the form of H. procumbens products.

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“…186 Pharmacological studies have shown that harpagide has a variety of biological activities, including antioxidant and radical scavenging, antiprotozoal, antibacterial, larvicidal, anti-inflammatory, antiosteoporotic, antidiabetic, anticancer, and neuroprotective activities. 187 Harpagide has been less studied in the treatment of neurological diseases, but Rong et al found that harpagide may have therapeutic effects in SCI. In their study, Rong et al suggested that harpagide alleviated neuronal apoptosis, inhibited glial scar formation, and promoted axonal regeneration by activating the Wnt/β-catenin signaling pathway, ultimately improving functional behavioral recovery in rats after SCI.…”

Section: Natural Compounds Regulate the Wnt Signaling Pathway In Ismentioning

confidence: 99%

“…ex Meisn . Pharmacological studies have shown that harpagide has a variety of biological activities, including antioxidant and radical scavenging, antiprotozoal, antibacterial, larvicidal, anti-inflammatory, antiosteoporotic, antidiabetic, anticancer, and neuroprotective activities . Harpagide has been less studied in the treatment of neurological diseases, but Rong et al found that harpagide may have therapeutic effects in SCI.…”

Section: Wnt Signaling Pathway and Neurological Disorders: Therapeuti...mentioning

confidence: 99%

Therapeutic Potential of Natural Compounds from Herbs and Nutraceuticals in Alleviating Neurological Disorders: Targeting the Wnt Signaling Pathway

Li,

Wang,

Zhang

2024

J. Agric. Food Chem.

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As an important signaling pathway in multicellular eukaryotes, the Wnt signaling pathway participates in a variety of physiological processes. Recent studies have confirmed that the Wnt signaling pathway plays an important role in neurological disorders such as stroke, Alzheimer's disease, and Parkinson's disease. The regulation of Wnt signaling by natural compounds in herbal medicines and nutraceuticals has emerged as a potential strategy for the development of new drugs for neurological disorders. Purpose: The aim of this review is to evaluate the latest research results on the efficacy of natural compounds derived from herbs and nutraceuticals in the prevention and treatment of neurological disorders by regulating the Wnt pathway in vivo and in vitro. A manual and electronic search was performed for English articles available from PubMed, Web of Science, and ScienceDirect from the January 2010 to February 2023. Keywords used for the search engines were "natural products,″ "plant derived products,″ "Wnt+ clinical trials,″ and "Wnt+,″ and/or paired with "natural products″/″plant derived products", and "neurological disorders." A total of 22 articles were enrolled in this review, and a variety of natural compounds from herbal medicine and nutritional foods have been shown to exert therapeutic effects on neurological disorders through the Wnt pathway, including curcumin, resveratrol, and querctrin, etc. These natural products possess antioxidant, anti-inflammatory, and angiogenic properties, confer neurovascular unit and blood−brain barrier integrity protection, and affect neural stem cell differentiation, synaptic formation, and neurogenesis, to play a therapeutic role in neurological disorders. In various in vivo and in vitro studies and clinical trials, these natural compounds have been shown to be safe and tolerable with few adverse effects. Natural compounds may serve a therapeutic role in neurological disorders by regulating the Wnt pathway. This summary of the research progress of natural compounds targeting the Wnt pathway may provide new insights for the treatment of neurological disorders and potential targets for the development of new drugs.

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Harpagide: Occurrence in plants and biological activities - A review

Cited by 13 publications

References 158 publications

Microfluidic Biosensor Decorated with an Indium Phosphate Nanointerface for Attomolar Dopamine Detection

Microfluidic Biosensor Decorated with an Indium Phosphate Nanointerface for Attomolar Dopamine Detection

The Fight against Infection and Pain: Devil’s Claw (Harpagophytum procumbens) a Rich Source of Anti-Inflammatory Activity: 2011–2022

Therapeutic Potential of Natural Compounds from Herbs and Nutraceuticals in Alleviating Neurological Disorders: Targeting the Wnt Signaling Pathway

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