Harnessing WYE-132 as an inhibitor of the mTOR signaling enriches the cytotoxicity effect of vinblastine in B16F10 melanoma cancer cells

Khaki‐Khatibi, Fatemeh; Zeinali, Mahdi; Ramezani, Bahman; Sabzichi, Mehdi; Mohammadian, Jamal; Hamishehkar, Hamed

doi:10.1016/j.procbio.2020.08.026

Cited by 13 publications

(4 citation statements)

References 43 publications

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“…Vinblastine sulfate (Figure 3m), is an effective anticancer agent used in the treatment of various cancer types, including lymphoma, breast cancer, testicular cancer, non-small cell lung cancer, bladder cancer, head and neck cancer, and cervical cancer. [111][112][113][114][115][116] Au and colleagues aimed to enhance the cytotoxicity of vinblastine on tumour cells by loading it onto graphene quantum dots. The graphene quantum dots-vinblastine composite remarkably inhibited cancer growth in animals.…”

Section: Vinca Alkaloidsmentioning

confidence: 99%

Harnessing Nanotechnology for Optimized Herbal Cancer Treatment: A Comprehensive Review of Nanoscale Drug Delivery Systems

Sadat Razavi,

Ahmadi,

Ebrahimnejad

et al. 2024

Pharm Sci

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Cancer is widely recognized as the second leading cause of death on a global scale. In recent years, nanotechnology has emerged as a promising strategy in the field of cancer therapy. Nanoscale drug delivery systems, a category of innovative technologies, harness the potential of various nanoparticles and nanomaterials to efficiently transport chemotherapeutic drugs, revolutionizing cancer treatment. The use of natural products has shown substantial promise in both the prevention and therapy of cancer. Herbal medicines, in particular, have gained widespread use due to their inherent therapeutic advantages and notably fewer adverse effects compared to modern drugs. However, their hydrophobic nature has presented a challenge, limiting their bioavailability and therapeutic efficacy. To overcome these limitations, researchers have developed nanocarriers tailored for the delivery of therapeutic agents to specific target cells. The combination of nanocarriers with herbal remedies results in improved bioavailability, enhanced pharmacological activity, and increased stability, all while minimizing systemic toxicity in cancer treatment. This review provides a comprehensive discussion of novel nanocarriers that find application in cancer treatment, with a specific focus on herbal medicine. The amalgamation of these innovative approaches offers promising prospects for the future of cancer therapy.

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Section: Vinca Alkaloidsmentioning

confidence: 99%

Harnessing Nanotechnology for Optimized Herbal Cancer Treatment: A Comprehensive Review of Nanoscale Drug Delivery Systems

Sadat Razavi,

Ahmadi,

Ebrahimnejad

et al. 2024

Pharm Sci

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“…The upper media of the plate wells were changed with 2 ml of fresh media containing the 48 h IC50 concentration of each treatment group. Then cells were incubated for 48 h. Following, cells were detached and stained via an annexin V/PI apoptosis detection kit (Exbio, Czech Republic) according to the manufacturer's protocol 56 . The rate of apoptosis was analyzed by flow cytometry (MACS Quant 10, Miltenyi Biotech GmbH).…”

Section: Cell Viability Study the Mtt Assay Technique Was Used To Evaluate The Cytotoxicity Effect Ofmentioning

confidence: 99%

Prevention of UV-induced skin cancer in mice by gamma oryzanol-loaded nanoethosomes

et al. 2021

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“…The antioxidant activity and stability during one year storage time of the GO and GO-NEs were determined using DPPH radical scavenging activity test 50 Following, cells were detached and stained via an annexin V/PI apoptosis detection kit (Exbio, Czech Republic) according to the manufacturer's protocol 56 . The rate of apoptosis was analyzed by flow cytometry (MACS Quant 10, Miltenyi Biotech GmbH).…”

Section: Radical Scavenging Activitymentioning

confidence: 99%

Prevention of UV-Induced Skin Cancer in Mice by Gamma Oryzanol-Loaded Nanoethosomes

Zeinali

Abbaspour‐Ravasjani

Soltanfam

et al. 2021

Preprint

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Skin cancer is the most widespread cancer worldwide, mainly caused by exposure to ultraviolet radiation (UV) in sunlight. Utilizing topical preventive agents in routinely daily used cosmetics may prevent UV-related skin damages and skin cancers. γ-Oryzanol (GO) is a natural component derived from rice bran oil, with potential antioxidant and skin anti-aging properties. We biologically thorough studied the antioxidant and anticancer effects of GO in vitro to found the effective signaling pathways, then evaluated the sun protection factor of prepared formulation, and finally investigated the long-term preventive effects of GO-loaded nanoethosomes (GO-NEs) against UVB-induced skin cancer in mice. Our results suggest that GO-NEs could effectively prevent UVB-induced skin cancer and could be utilized as an innovative ingredient in cosmetics.

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Harnessing WYE-132 as an inhibitor of the mTOR signaling enriches the cytotoxicity effect of vinblastine in B16F10 melanoma cancer cells

Cited by 13 publications

References 43 publications

Harnessing Nanotechnology for Optimized Herbal Cancer Treatment: A Comprehensive Review of Nanoscale Drug Delivery Systems

Harnessing Nanotechnology for Optimized Herbal Cancer Treatment: A Comprehensive Review of Nanoscale Drug Delivery Systems

Prevention of UV-induced skin cancer in mice by gamma oryzanol-loaded nanoethosomes

Prevention of UV-Induced Skin Cancer in Mice by Gamma Oryzanol-Loaded Nanoethosomes

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