Harnessing the tumour-derived cytokine, CSF-1, to co-stimulate T-cell growth and activation

Lo, Agnes S.; Taylor, Jessica Rhiannon; Farzaneh, Farzin; Kemeny, David M.; Dibb, Nick J.; Maher, John

doi:10.1016/j.molimm.2007.09.010

Cited by 41 publications

(29 citation statements)

References 52 publications

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“…H29D retroviral packaging cells were a gift from Dr. Michel Sadelain (Memorial Sloan Kettering Cancer Center, New York) and were propagated as described (2). CTLL-2 is a murine IL-2-dependent CD8 ϩ T-cell line (gift from Dr. Alastair Noble, King's College London) and was maintained as described (39). Retroviral transduction of CTLL-2 cells was achieved using supernatant derived from H29D retroviral packaging cells (2).…”

Section: Methodsmentioning

confidence: 99%

Selective Expansion of Chimeric Antigen Receptor-targeted T-cells with Potent Effector Function using Interleukin-4

Wilkie

Burbridge

Chiapero-Stanke

et al. 2010

Journal of Biological Chemistry

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168

151

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Polyclonal T-cells can be directed against cancer using transmembrane fusion molecules known as chimeric antigen receptors (CARs). Although preclinical studies have provided encouragement, pioneering clinical trials using CAR-based immunotherapy have been disappointing. Key obstacles are the need for robust expansion ex vivo followed by sustained survival of infused T-cells in patients. To address this, we have developed a system to achieve selective proliferation of CAR ؉ T-cells using

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Section: Methodsmentioning

confidence: 99%

Selective Expansion of Chimeric Antigen Receptor-targeted T-cells with Potent Effector Function using Interleukin-4

Wilkie

Burbridge

Chiapero-Stanke

et al. 2010

Journal of Biological Chemistry

Self Cite

168

151

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“…The authors described that M-CSF-conditioned human DC precursors responded to LPS, Mycobacteria bovis, and inflammatory cytokines by a rapid and robust production of IL-10. It has been proposed a synergistic enhancement of IL-2-driven T-cell proliferation induced by CSF [30]. In addition, CSF also co-stimulated the production of interferon (IFN)-gamma by activated T-cells.…”

Section: Resultsmentioning

confidence: 99%

Modulation of the Serum Cytokine Expression Pattern in Hymenoptera Allergic Patients Treated with Specific Venom Immunotherapy

Sanz¹,

Isidoro‐García

Dávila³

et al. 2012

TOIJ

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Venom immunotherapy (VIT) is an adequate model to explore the immune mechanisms underlying this type of treatment. We have investigated the use of protein arrays to detect variations in the levels of cytokines in patients receiving VIT. In the present study we selected 11 non-atopic patients with systemic reactions after Hymenoptera sting that received VIT during at least three years. In order to evaluate the success of VIT all of them should have tolerated a sting field after VIT. Serum samples were obtained before initiating VIT and after at least three years of successful VIT. We analyzed 42 serum proteins corresponding to a Th1/Th2 panel using protein array methodology. We observed a significant increase of Interleukin 10, Myeloid Macrophage Colony Stimulation Factor, Macrophage Derived Chemokine, Interleukin 1-, Vascular Endothelial Growing Factor and Stem Cell Factor serum levels after successful VIT. We discuss the usefulness and normalization of this array method to analyze cytokines and other serum proteins. Monitoring these serum cytokines could help to predict the response and to elucidate the mechanisms underlying immunotherapy.

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“…It remains to be seen if the amount of delivered photosensitizer will also be sufficient for an efficient PDT. On the other hand, a variety of experimental strategies are under investigation to improve the trafficking of adoptively transferred T lymphocytes to malignant tissues [34][35][36]. Thus, there is potential that the T cell-based targeted PDT approach may lead to a better photosensitizer biodistribution toward the tumor sites than systemically administered drug.…”

Section: Discussionmentioning

confidence: 99%

A photosensitizer delivered by bispecific antibody redirected T lymphocytes enhances cytotoxicity against EpCAM-expressing carcinoma cells upon light irradiation

Blaudszun

Moldenhauer

Schneider

et al. 2015

Journal of Controlled Release

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Harnessing the tumour-derived cytokine, CSF-1, to co-stimulate T-cell growth and activation

Cited by 41 publications

References 52 publications

Selective Expansion of Chimeric Antigen Receptor-targeted T-cells with Potent Effector Function using Interleukin-4

Selective Expansion of Chimeric Antigen Receptor-targeted T-cells with Potent Effector Function using Interleukin-4

Modulation of the Serum Cytokine Expression Pattern in Hymenoptera Allergic Patients Treated with Specific Venom Immunotherapy

A photosensitizer delivered by bispecific antibody redirected T lymphocytes enhances cytotoxicity against EpCAM-expressing carcinoma cells upon light irradiation

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