Harnessing the power of biological macromolecules in hydrogels for controlled drug release in the central nervous system: A review

Ghosh, Shampa; Ghosh, Soumya; Sharma, Hitaishi; Bhaskar, Rakesh; Han, Sung Soo; Sinha, Jitendra Kumar

doi:10.1016/j.ijbiomac.2023.127708

Cited by 4 publications

(4 citation statements)

References 227 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therapeutic agents, including small compounds, peptides, proteins, nucleic acids, cells, and extracellular vesicles, are the key component of stimuli-responsive hydrogels, playing a pivotal role in brain disease treatment by reducing ROS damage and inflammation, promoting neural regeneration, and inducing tumor cell death ( Ghosh et al, 2024 ). To achieve precise and controlled targeted delivery of therapeutic agents, these hydrogels capitalize on the patient’s physiological and pathological environments.…”

Section: Design Principle Of Stimuli-responsive Hydrogels For Brain D...mentioning

confidence: 99%

“…Brain diseases typically exhibit pathological features such as neural loss or death, vascular dysfunction, inflammation, oxidative stress, and increased expression of MMPs in affected tissues ( El-Husseiny et al, 2022 ; Ghosh et al, 2024 ). These environmental cues can be exploited by hydrogels that respond to various stimuli, enabling targeted therapeutic delivery.…”

Section: Preclinical Progress In Utilizing Stimuli-responsive Hydroge...mentioning

confidence: 99%

“…Their water-absorbing and swelling characteristics mimic the natural extracellular matrix (ECM), fostering an optimal environment for cellular growth and tissue engineering ( Ma and Huang, 2020 ). Furthermore, they excel in encapsulating a range of therapeutic agents, including neuroprotective agents, chemotherapeutic drugs and even cells, and releasing them in a controlled manner, positioning them as exceptional candidates for drug delivery systems ( Ghosh et al, 2024 ). Stimuli-responsive hydrogels have demonstrated encouraging potential in treating brain diseases over the past few decades ( Peressotti et al, 2021 ; Grimaudo et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Application of stimuli-responsive hydrogel in brain disease treatment

Xie,

Xie

2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Treating brain diseases presents significant challenges due to neuronal degeneration, inflammation, and the intricate nature of the brain. Stimuli-responsive hydrogels, designed to closely resemble the brain’s extracellular matrix, have emerged as promising candidates for controlled drug delivery and tissue engineering. These hydrogels have the unique ability to encapsulate therapeutic agents and release them in a controlled manner when triggered by environmental stimuli. This property makes them particularly suitable for delivering drugs precisely to targeted areas of the brain, while minimizing collateral damage to healthy tissue. Their preclinical success in treating various brain diseases in animal studies underscores their translational potential for human brain disease treatment. However, a deeper understanding of their long-term behavior, biodistribution, and biocompatibility within the brain remains crucial. Furthermore, exploring novel hydrogel systems and therapeutic combinations is paramount for advancing towards more effective treatments. This review summarizes the latest advancements in this field over the past 5 years, specifically highlighting preclinical progress with novel stimuli-responsive hydrogels for treating brain diseases.

show abstract

Section: Design Principle Of Stimuli-responsive Hydrogels For Brain D...mentioning

confidence: 99%

Section: Preclinical Progress In Utilizing Stimuli-responsive Hydroge...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Application of stimuli-responsive hydrogel in brain disease treatment

Xie,

Xie

2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Several review articles about injectable hydrogels for nervous tissue repair have been previously reported [ 26 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ]. Recently, Gao et al [ 29 ] published a review article describing injectable hydrogels in nerve repair and regeneration after ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

Injectable Hydrogels for Nervous Tissue Repair—A Brief Review

Politrón-Zepeda,

Fletes-Vargas,

Rodríguez-Rodríguez

2024

Gels

View full text Add to dashboard Cite

The repair of nervous tissue is a critical research field in tissue engineering because of the degenerative process in the injured nervous system. In this review, we summarize the progress of injectable hydrogels using in vitro and in vivo studies for the regeneration and repair of nervous tissue. Traditional treatments have not been favorable for patients, as they are invasive and inefficient; therefore, injectable hydrogels are promising for the treatment of damaged tissue. This review will contribute to a better understanding of injectable hydrogels as potential scaffolds and drug delivery system for neural tissue engineering applications.

show abstract