Harnessing the Electric Spark of Life to Cure Skin Wounds

Martin-Granados, Christina; McCaig, Colin

doi:10.1089/wound.2013.0451

Cited by 49 publications

(47 citation statements)

References 60 publications

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“…Recently we have witnessed a steady increase in therapeutic devices and wound dressings utilizing the influence of static or dynamic electric fields [4][5][6][7][8] including the two electroceuticals addressed in this paper [7,8]. At the same time we have witnessed an increased understanding of how the microscopic molecular processes are influenced by the exogenous electric fields [9,10]. Since bacterial contamination is of importance in the wound context studies have also been made on the influence of electrical fields on bacterial cultures [11].…”

Section: Introductionmentioning

confidence: 99%

Electrical field landscape of two electroceuticals

Wahlsten

Skiba²,

Makin

et al. 2016

Journal of Electrical Bioimpedance

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In recent years several electrical wound management systems, so called electroceuticals, have been introduced claiming an induced electrical response in the wounded tissue. Some have external current and voltage sources while others have internal constructions aiming at creating necessary therapeutic currents. We investigate two representative electroceuticals by mapping out their electrical field landscapes using a previously developed skin model within a numerical simulation scheme. We find very strong fields from the electroceuticals of the order of 1 kV/m amenable for electrotaxic influence on pertinent cell types for wound healing. Current densities can locally be as high as 1 A/cm 2 .

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Section: Introductionmentioning

confidence: 99%

Electrical field landscape of two electroceuticals

Wahlsten

Skiba²,

Makin

et al. 2016

Journal of Electrical Bioimpedance

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“…3 Chronic lower extremity wounds represent a significant burden on patients' quality of life and the healthcare system. 4,5 Although there are standard treatment modalities available for the management of lower extremity wounds based on aetiology including revascularisation, 6 compression therapy, 7 offloading 8-11 and pressure relief, 12 they are not always effective. Adjuvant therapies are also available but their optimal use is unknown.…”

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confidence: 99%

The efficacy of electrical stimulation in lower extremity cutaneous wound healing: A systematic review

Ashrafi

Alonso-Rasgado

Baguneid

et al. 2017

Experimental Dermatology

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Current gold standard lower extremity cutaneous wound management is not always effective. Cutaneous wounds generate a "current of injury" which is directly involved in wound healing processes. Application of exogenous electrical stimulation has been hypothesised to imitate the natural electric current that occurs in cutaneous wounds.The aim of this extensive review was to provide a detailed update on the variety of electrical stimulation modalities used in the management of lower extremity wounds.Several different waveforms and delivery methods of electrical stimulation have been used. Pulsed current appears superior to other electrical modalities available. The majority of studies support the beneficial effects of pulsed current over conservative management of lower extremity cutaneous wounds. Although it appears to have no benefit over causal surgical intervention, it is a treatment option which could be utilised in those patients unsuitable for surgery. Other waveforms and modalities appear promising; however, they still lack large trial data to recommend a firm conclusion with regards to their use. Current studies also vary in quantity, quality and protocol across the different modalities. The ideal electrical stimulation device needs to be noninvasive, portable and cost-effective and provides minimal interference with patients' daily life. Further studies are necessary to establish the ideal electrical stimulation modality, parameters, method of delivery and duration of treatment. The development and implementation of newer devices in the management of acute and chronic wounds provides an exciting direction in the field of electrotherapy. K E Y W O R D Selectrotherapy, humans, skin wounds

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“…Directional and persistent cell migration is guided by different gradient cues, such as chemotaxis (soluble factors), electrotaxis (electric fields), durotaxis (mechanical signals) as well as haptotaxis (adhesive proteins) . The gradient materials inspired by this mechanism with gradually changing physical or chemical properties have been used to regulate directional migration of cells in recent years .…”

Section: Introductionmentioning

confidence: 99%

Selective Adhesion and Directional Migration of Endothelial Cells Guided by Cys‐Ala‐Gly Peptide Density Gradient on Antifouling Polymer Brushes

Gao

2019

Macromolecular Bioscience

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Selective adhesion and directional migration of endothelial cells (ECs) on biomaterials is critical to realize the rapid endothelialization. In this study, a Cys‐Ala‐Gly (CAG) peptide density gradient is generated on homogeneous cell‐resisting poly(2‐hydroxyethyl methacrylate‐co‐glycidyl methacrylate) brushes by immersing the brushes in a complementary gradient solution of CAG and competitive mercapto‐terminated methoxyl poly(ethylene glycol). The adhesion and spreading of smooth muscle cells (SMCs) is impaired effectively on the gradient surface. About six folds of adherent ECs over SMCs are achieved at the position (10 mm) of highest CAG density on the gradient surface in a co‐culture condition. Due to the gradient cues, ECs migrate fastest with the best directionality of 86.7% at the middle of the gradient, leading to the maximum net displacement as well.

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Harnessing the Electric Spark of Life to Cure Skin Wounds

Cited by 49 publications

References 60 publications

Electrical field landscape of two electroceuticals

Electrical field landscape of two electroceuticals

The efficacy of electrical stimulation in lower extremity cutaneous wound healing: A systematic review

Selective Adhesion and Directional Migration of Endothelial Cells Guided by Cys‐Ala‐Gly Peptide Density Gradient on Antifouling Polymer Brushes

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