Harnessing strategies for enhancing diabetic wound healing from the perspective of spatial inflammation patterns

Cai, Yong; Chen, Kangli; Liu, Changsheng; Qu, Xue

doi:10.1016/j.bioactmat.2023.04.019

Cited by 22 publications

(20 citation statements)

References 116 publications

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“…7 B). CD68 is a surface marker for macrophages that flanks the extent of inflammatory cell infiltration [ 42 ]. The infiltration of inflammatory cells and the expression of the inflammatory factor TNF-α were decreased in both the LCH@CNZs and LCH@EVs groups, with the anti-inflammatory ability being slightly stronger in the LCH@CNZs group.…”

Section: Resultsmentioning

confidence: 99%

Microenvironment Remodeling Self-Healing Hydrogel for Promoting Flap Survival

Ju,

Yang,

Liu

et al. 2024

Biomater Res

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Random flap grafting is a routine procedure used in plastic and reconstructive surgery to repair and reconstruct large tissue defects. Flap necrosis is primarily caused by ischemia–reperfusion injury and inadequate blood supply to the distal flap. Ischemia–reperfusion injury leads to the production of excessive reactive oxygen species, creating a pathological microenvironment that impairs cellular function and angiogenesis. In this study, we developed a microenvironment remodeling self-healing hydrogel [laminarin–chitosan-based hydrogel-loaded extracellular vesicles and ceria nanozymes (LCH@EVs&CNZs)] to improve the flap microenvironment and synergistically promote flap regeneration and survival. The natural self-healing hydrogel (LCH) was created by the oxidation laminarin and carboxymethylated chitosan via a Schiff base reaction. We loaded this hydrogel with CNZs and EVs. CNZs are a class of nanomaterials with enzymatic activity known for their strong scavenging capacity for reactive oxygen species, thus alleviating oxidative stress. EVs are cell-secreted vesicular structures containing thousands of bioactive substances that can promote cell proliferation, migration, differentiation, and angiogenesis. The constructed LCH@EVs&CNZs demonstrated a robust capacity for scavenging excess reactive oxygen species, thereby conferring cellular protection in oxidative stress environments. Moreover, these constructs notably enhance cell migration and angiogenesis. Our results demonstrate that LCH@EVs&CNZs effectively remodel the pathological skin flap microenvironment and marked improve flap survival. This approach introduces a new therapeutic strategy combining microenvironmental remodeling with EV therapy, which holds promise for promoting flap survival.

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Section: Resultsmentioning

confidence: 99%

Microenvironment Remodeling Self-Healing Hydrogel for Promoting Flap Survival

Ju,

Yang,

Liu

et al. 2024

Biomater Res

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“…The relationship between inflammation and wound repair is a complex and dynamic process that involves various cellular and molecular interactions 38 , 48 , 49 . When tissue damage occurs, inflammatory cells such as neutrophils and macrophages are recruited to the site of injury, where they release cytokines and chemokines, promoting inflammation and attracting other immune cells to clear debris and pathogens from the wound area, thereby initiating a crucial initial inflammatory response 50 .…”

Section: Discussionmentioning

confidence: 99%

Injectable hydrogel with doxorubicin-loaded ZIF-8 nanoparticles for tumor postoperative treatments and wound repair

Zhang,

Chen

et al. 2024

Sci Rep

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The need for tumor postoperative treatments aimed at recurrence prevention and tissue regeneration have raised wide considerations in the context of the design and functionalization of implants. Herein, an injectable hydrogel system encapsulated with anti-tumor, anti-oxidant dual functional nanoparticles has been developed in order to prevent tumor relapse after surgery and promote wound repair. The utilization of biocompatible gelatin methacryloyl (GelMA) was geared towards localized therapeutic intervention. Zeolitic imidazolate framework-8@ceric oxide (ZIF-8@CeO2, ZC) nanoparticles (NPs) were purposefully devised for their proficiency as reactive oxygen species (ROS) scavengers. Furthermore, injectable GelMA hydrogels loaded with ZC NPs carrying doxorubicin (ZC-DOX@GEL) were tailored as multifunctional postoperative implants, ensuring the efficacious eradication of residual tumor cells and alleviation of oxidative stress. In vitro and in vivo experiments were conducted to substantiate the efficacy in cancer cell elimination and the prevention of tumor recurrence through the synergistic chemotherapy approach employed with ZC-DOX@GEL. The acceleration of tissue regeneration and in vitro ROS scavenging attributes of ZC@GEL were corroborated using rat models of wound healing. The results underscore the potential of the multifaceted hydrogels presented herein for their promising application in tumor postoperative treatments.

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“…However, in patients with diabetic wounds, high blood sugar can reduce the activity of various enzymes in neutrophils and their ability to kill bacteria on the one hand and lead to phagocytic dysfunction of macrophages and their easy conversion to a senescent phenotype on the other hand, resulting in a decreased ability to clear inflammation and prolonged chronic inflammation. 39–41…”

Section: Challenges In Diabetic Wound Treatmentmentioning

confidence: 99%

“…Additionally, substances such as hemoglobin-derived factor, plasminogen, and substance P are believed to reverse the chronic inflammatory state of diabetes and restore the acute phenotype. 39…”

Section: Smart Hydrogels For Wound Therapymentioning

confidence: 99%