Abstract:Based on the “canonical”
view of reactive oxygen
species’ (ROS) contribution to carcinogenesis, ROS induce oxidative
stress and promote various tumor progression events. However, tumor
cells also need to defend themselves against oxidative damage. This
“heresy” was supported by several recent studies underlining
the role of cellular antioxidant capacity in promoting metastasis
and resistance to chemotherapy. Accordingly, harnessing the ROS-induced
oxidative stress via selective suppression of the cancer antiox… Show more
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