Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases

Singh, Navneet; Vishwas, Sukriti; Kaur, Amandeep; Kaur, Harmanpreet; Kakoty, Violina; Khursheed, Rubiya; Chaitanya, M.V.N.L.; Babu, Molakpogu Ravindra; Awasthi, Ankit; corrie, Leander; Harish, Vancha; Yanadaiah, Palakurthi; Gupta, Saurabh; Sayed, Amany A.; El-Sayed, Amr; Ali, Iftikhar; Kensara, Osama A.; Ghaboura, Nehmat; Gupta, Gaurav; Dou, Ali M.; Algahtani, Mohammad; El-kott, Attalla F.; Dua, Kamal; Singh, Sachin Kumar; Abdel-Daim, Mohamed M.

doi:10.1016/j.biopha.2023.115512

Cited by 10 publications

(2 citation statements)

References 91 publications

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“…In this study, about 63.64% were confirmed to be E. coli, which is higher than the previous study by Haberecht et al, who reported that the percentage of total detected bacteria, E. coli, was 37% in wastewater [46]. These elevations in E. coli in wastewater were described in previous studies as being due to the proximity of fecal contamination from humans and animals [47][48][49][50]. However, as reported in previous studies, K. pneumoniae strains were considered to have come from hospitals and receiving wastewater treatment plants [51][52][53].…”

Section: Discussioncontrasting

confidence: 65%

Biocide Syntheses Bee Venom-Conjugated ZnO@αFe2O3 Nanoflowers as an Advanced Platform Targeting Multidrug-Resistant Fecal Coliform Bacteria Biofilm Isolated from Treated Wastewater

Sharaf,

Mohammed,

Farahat

et al. 2023

Microbiology Research

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This study targeted developing a novel Zinc oxide with alpha hematite nanoflowers (NFs)-loaded bee venom (Bv) (Bv-ZnO@αFe2O3 NFs) as a bio-natural product from bees to combine both the advantages of combination magnetic properties and the antimicrobial and anti-biofilm properties on isolated coliform bacteria from the effluent of wastewater treatment plants. About 24 isolates of treated wastewater isolates were multidrug resistant (MDR). The phylogenetic grouping of Escherichia coli (E. coli) and Klebsiella pneumonia (K. pneumonia) showed that the largest group was Group A, followed by Group B2 and Group B1. Fourier transform infrared (FTIR), The X-ray diffraction (XRD), and scanning electron microscopy-energy dispersive X-ray analysis (SEM− EDX) validated the coating operation’s contact with Bv onto ZnO@αFe2O3 NFs. According to high-resolution transmission electron microscopy (TEM) and selected area electron diffraction (SAED), pattern analyses for prepared nanoformulations exhibited a spherical shape of αFe2O3 (~9–15 nm), and floral needle shapes with uniform distribution of size with aggregation of ZnOαFe2O3 and Bv-ZnO@αFe2O3 NFs around (~100–200 nm). The toxicity of Bv-ZnO@αFe2O3 NFs was comparable up to 125 µg mL−1, when it reached 64.79% (IC50, 107.18 µg mL−1). The antibacterial activity showed different zones of inhibition against different isolates. The biofilm inhibitory activity of NPs and NFs showed a highly significant reduction (p < 0.001) in treated biofilms with ZnO@αFe2O3 and Bv-ZnO@αFe2O3. In essence, ZnO@αFe2O3 and Bv-ZnO@αFe2O3 NFs are promising antimicrobials for inhibiting the growth and biofilm of MDR E. coli and K. pneumonia isolates, thereby, biocontrol of wastewater.

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Section: Discussioncontrasting

confidence: 65%

Biocide Syntheses Bee Venom-Conjugated ZnO@αFe2O3 Nanoflowers as an Advanced Platform Targeting Multidrug-Resistant Fecal Coliform Bacteria Biofilm Isolated from Treated Wastewater

Sharaf,

Mohammed,

Farahat

et al. 2023

Microbiology Research

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“…By encouraging antioxidative defense systems for neutralizing free radicals and by limiting transcription, the antioxidant system is crucial for saving neuronal cells from OS and maintaining the proper redox balance in the brain tissue. Sesamol has been found to boost the action of various antioxidant enzymes, namely glutathione reductase, CAT, SOD, GPx, and also non-enzymatic antioxidants (vitamin E, GSH, and vitamin C), thereby reducing the levels of the lipid peroxidation and nitrites [157][158][159][160].…”

Section: Phenolic Alcoholsmentioning

confidence: 99%

Emerging Role of Plant-Based Bioactive Compounds as Therapeutics in Parkinson’s Disease

Kumari,

Anand,

Shah

et al. 2023

Molecules

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Neurological ailments, including stroke, Alzheimer’s disease (AD), epilepsy, Parkinson’s disease (PD), and other related diseases, have affected around 1 billion people globally to date. PD stands second among the common neurodegenerative diseases caused as a result of dopaminergic neuron loss in the midbrain’s substantia nigra regions. It affects cognitive and motor activities, resulting in tremors during rest, slow movement, and muscle stiffness. There are various traditional approaches for the management of PD, but they provide only symptomatic relief. Thus, a survey for finding new biomolecules or substances exhibiting the therapeutic potential to patients with PD is the main focus of present-day research. Medicinal plants, herbal formulations, and natural bioactive molecules have been gaining much more attention in recent years as synthetic molecules orchestrate a number of undesired effects. Several in vitro, in vivo, and in silico studies in the recent past have demonstrated the therapeutic potential of medicinal plants, herbal formulations, and plant-based bioactives. Among the plant-based bioactives, polyphenols, terpenes, and alkaloids are of particular interest due to their potent anti-inflammatory, antioxidant, and brain-health-promoting properties. Further, there are no concise, elaborated articles comprising updated mechanism-of-action-based reviews of the published literature on potent, recently investigated (2019–2023) medicinal plants, herbal formulations, and plant based-bioactive molecules, including polyphenols, terpenes, and alkaloids, as a method for the management of PD. Therefore, we designed the current review to provide an illustration of the efficacious role of various medicinal plants, herbal formulations, and bioactives (polyphenols, terpenes, and alkaloids) that can become potential therapeutics against PD with greater specificity, target approachability, bioavailability, and safety to the host. This information can be further utilized in the future to develop several value-added formulations and nutraceutical products to achieve the desired safety and efficacy for the management of PD.

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Long‐term exposure of sucralose induces neuroinflammation and ferroptosis in human microglia cells via SIRT1/NLRP3/IL‐1β/GPx4 signaling pathways

Hacioglu

2024

Food Science & Nutrition

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Microglia serve as the primary defense mechanism in the brain. Artificial sweeteners are widely used as dietary supplements, though their long‐term effects remain uncertain. In this study, we investigated the effects of sucralose on microglia during prolonged exposure via the neuroinflammatory and ferroptosis pathways. Initially, human microglial clone 3 (HMC3) cells were exposed to sucralose (0–50 mM) for 24, 48, and 72 h to investigate the short‐term effects. Subsequently, HMC3 cells were treated with 1 mM sucralose for 7, 14, and 21 days to examine long‐term effects. We measured levels of interleukin‐1β (IL‐1β), NOD‐like receptor protein 3 (NLRP3), 8‐hydroxydeoxyguanosine (8‐OHdG), Sirtuin‐1 (SIRT1), glutathione peroxidase‐4 (GPx4), reduced glutathione (GSH), malondialdehyde (MDA), ferrous iron (Fe2+), and caspase 3/7. Additionally, we analyzed the impact of sucralose on cell morphology, migration, and expression levels of IL‐1β, NLRP3, SIRT1, and GPx4. Sucralose inhibited cell viability and proliferation in HMC3 cells in a concentration‐ and time‐dependent manner and induced membrane and nuclear abnormalities. Moreover, sucralose significantly reduced the cell migration rate. Long‐term sucralose treatment decreased Fe2+, GPx4, GSH, and SIRT1 levels in HMC3 cells while increasing IL‐1β, MDA, NLRP3, 8‐OHdG, and caspase 3/7 activity. Sucralose treatment also enhanced microglial activation and neuroinflammation by upregulating IL‐1β and NLRP3 and downregulating SIRT1 and GPx4, thereby inducing ferroptosis and suppressing cell viability. Consequently, high concentrations or long‐term sucralose treatment may induce neuroinflammation and ferroptosis by targeting the SIRT1/NLRP3/IL‐1β/GPx4 pathway in HMC3 cells.

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Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases

Cited by 10 publications

References 91 publications

Biocide Syntheses Bee Venom-Conjugated ZnO@αFe2O3 Nanoflowers as an Advanced Platform Targeting Multidrug-Resistant Fecal Coliform Bacteria Biofilm Isolated from Treated Wastewater

Biocide Syntheses Bee Venom-Conjugated ZnO@αFe2O3 Nanoflowers as an Advanced Platform Targeting Multidrug-Resistant Fecal Coliform Bacteria Biofilm Isolated from Treated Wastewater

Emerging Role of Plant-Based Bioactive Compounds as Therapeutics in Parkinson’s Disease

Long‐term exposure of sucralose induces neuroinflammation and ferroptosis in human microglia cells via SIRT1/NLRP3/IL‐1β/GPx4 signaling pathways

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