Harnessing open-source technology for low-cost automation in synthesis: Flow chemical deprotection of silyl ethers using a homemade autosampling system

Abstract

Harnessing open-source technology for low-cost automation in synthesis: flow chemical deprotection of silyl ethers using a homemade autosampling system.,

OpenFlowChem – a platform for quick, robust and flexible automation and self-optimisation of flow chemistry

“…11,28,35 However, all these methods are very costly, which creates a high adoption barrier for applications. 59 In the case of a gas-liquid reaction, a more affordable approach is to monitor the hydrogen consumption using either a gas flow meter or an inline liquid sensor placed downstream the reactor.…”

“…There are only a few researchers who share the automation codes, notably O'Brien and Ingham. [21][22][23][24][25] The lack of automation dissemination is exemplified by only a handful groups in the world which demonstrated the process self-optimisation of chemical reactors. 10,[26][27][28][29] Poliakoff and co-workers showed self-optimisation in various reactions, optimised for the product yield and even obtained several products from the same system.…”

Arduino‐based slider setup for gas–liquid mass transfer investigations: Experiments and CFD simulations

“…Another trend in micro process engineering is the integration of low‐cost automation based on open‐source technology in order to improve laboratory safety and reduce time‐consuming practices . Computer‐vision controlled liquid–liquid extraction steps are reported in literature that facilitate the automation of an iodination and desilylation reaction by utilizing a Raspberry Pi single‐board computer and open‐source software technologies such as Python and OpenCV . A liquid‐handling chemorobotic platform based on the open‐source “RepRap” 3D printer with OpenCV as core component for the computer‐vision system was used by Gutierrez et al to investigate the properties of oil droplets via an automated evolutionary process .…”

An automated colorimetric inline titration of CO2 concentrations in solvent flow streams using a Teflon AF-2400 tube-in-tube device

“…[54] In this manuscript we report the development of an automated inline colorimetric titration of CO 2 concentrations in acetonitrile flow streams generated using a Teflon AF-2400 tube-in-tube device. Incorporating a number of open-source software components (OpenCV, [55,56] Python, [57] SciPy [58,59], PySerial[60]) in combination with an inexpensive webcam device, the methodology described builds on our previous research in this area [61][62][63][64][65][66] and uses a computer-vision approach [67] to determine the colorimetric endpoint.…”