Harnessing Omics Sciences and Biotechnologies in Understanding Osseointegration— Personalized Dental Implant Therapy

Refai, Ali K.; Cochran, David L.

doi:10.11607/jomi.7272

Cited by 10 publications

(17 citation statements)

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“…In this line, advanced omics technologies may confer novel approaches for further understanding of cell-to-cell communication and genes profiling during inflammo-immuno-angio-neuro-osteogenesis process and osseointegration, with the aim of evolving new modalities and strategies in implant therapy. 96 Furthermore, through molecular approaches and genetic data, we will be able to reveal the molecular basis of osseointegration to ultimately pave the way for personalized implant therapy. In this regards, it has been hypothesized that residual ridge resorption (RRR) may have a genetic association resulting from genome sequence variation between individuals in terms of single nucleotide polymorphisms (SNPn).…”

Section: Omics Sciences and Personalized Dental Implant Therapymentioning

confidence: 99%

“…96 Herein is the importance of breakthrough technologies and the development of now conceptual fields such as implantomics which would allow us to individualize the treatment with dental implants to different osetoimmune peri-implant scenarios. 96…”

Section: Omics Sciences and Personalized Dental Implant Therapymentioning

confidence: 99%

“…In recent years there has been a notable scientific trend in the use of omics sciences and technologies to gain new insights into how different molecules interact and crosstalk at the biomaterial interface. In this line, advanced omics technologies may confer novel approaches for further understanding of cell‐to‐cell communication and genes profiling during inflammo‐immuno‐angio‐neuro‐osteogenesis process and osseointegration, with the aim of evolving new modalities and strategies in implant therapy 96 …”

Section: Immune‐centered Therapeutic Approaches For Clinical Improvem...mentioning

confidence: 99%

“…In this regards, it has been hypothesized that residual ridge resorption (RRR) may have a genetic association resulting from genome sequence variation between individuals in terms of single nucleotide polymorphisms (SNPn). The presence of SNPn may lead to genetic diagnostic tests, which should identify patients at risk of alveolar bone resorption 96 . Herein is the importance of breakthrough technologies and the development of now conceptual fields such as implantomics which would allow us to individualize the treatment with dental implants to different osetoimmune peri‐implant scenarios 96 …”

Section: Immune‐centered Therapeutic Approaches For Clinical Improvem...mentioning

confidence: 99%

“…The presence of SNPn may lead to genetic diagnostic tests, which should identify patients at risk of alveolar bone resorption 96 . Herein is the importance of breakthrough technologies and the development of now conceptual fields such as implantomics which would allow us to individualize the treatment with dental implants to different osetoimmune peri‐implant scenarios 96 …”

Section: Immune‐centered Therapeutic Approaches For Clinical Improvem...mentioning

confidence: 99%

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Implications of considering peri‐implant bone loss a disease, a narrative review

Albrektsson

Tengvall

Amengual‐Peñafiel

et al. 2022

Clin Implant Dent Rel Res

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Background Peri‐implantitis has been suggested to cause significant increasing proportions of implant failure with increasing time. Purpose To assess whether implant failure rates in long term studies are matching the supposed high prevalence of peri‐implantitis. Material and Methods This paper is written as a narrative review of the long‐term clinical investigations available in the literature. Results Some implant systems have seen unacceptable marginal bone loss figures with time coupled to increased implant failure rates, resulting in the withdrawal of these systems. The reasons for such mishap are generally unknown, with the exception of one system failure that was found to be due to improper clinical handling. Modern, moderately rough implant systems have functioned excellently over 10–15 years of follow up with minor problems with marginal bone loss and implant failure rates within a few per cent. Machined implants have functioned adequately over 20–30 years of follow up. Implant failures occur predominantly during the first few years after implant placement. No significant increase of implant failures has been observed thereafter over 20–30 years of follow up. Over the years of our new millennium, scientific and technical advances have allowed the discovery of numerous molecular pathways and cellular interactions between the skeletal and immune system promoting the development of the interdisciplinary field called osteoimmunology. Nowadays, this knowledge has not only allowed the emergence of new etiologic paradigms for bone disease but also a new dynamic approach on the concept of osseointegration and MBL around oral implants, re‐evaluating our older disease oriented outlook. This facilitates at the same time the emergence of translational applications with immunological perspectives, scientific approaches based on omics sciences, and the beginning of an era of personalized dental implant therapy to improve the prognosis of oral implant treatment. Conclusions Oral implant systems have been found to function with very good clinical outcome over follow‐up times of 20–30 years. Registered implant failures have occurred predominantly during the first few years after implantation, and there has been no significant increase in late failures due to peri‐implantitis.

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Section: Omics Sciences and Personalized Dental Implant Therapymentioning

confidence: 99%

Section: Omics Sciences and Personalized Dental Implant Therapymentioning

confidence: 99%

Section: Immune‐centered Therapeutic Approaches For Clinical Improvem...mentioning

confidence: 99%

Section: Immune‐centered Therapeutic Approaches For Clinical Improvem...mentioning

confidence: 99%

Section: Immune‐centered Therapeutic Approaches For Clinical Improvem...mentioning

confidence: 99%

See 3 more Smart Citations

Implications of considering peri‐implant bone loss a disease, a narrative review

Albrektsson

Tengvall

Amengual‐Peñafiel

et al. 2022

Clin Implant Dent Rel Res

View full text Add to dashboard Cite

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Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

Cagna

Donovan

McKee³

et al. 2021

The Journal of Prosthetic Dentistry

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Bridging the gap between omics research and dental practice

Kabbashi,

Roomaney,

Chetty

2024

BDJ Open

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Aim The burgeoning field of omics research has witnessed exponential growth in both medicine and dentistry. However, despite more than a decade of advancements, clinical dentistry, particularly in Low- and Middle-Income Countries (LMICs), has seen limited progress in integrating omics-based approaches into routine practice. This review aims to provide a comprehensive overview of the integration of omics approaches in dentistry, focusing on the challenges and opportunities for translating research findings into clinical practice. Methods we conducted a literature review using key databases to provide a brief overview of the history of genomics in dentistry. Additionally, we summarised recent breakthroughs in omics relevant to oral health practitioners, emphasising the inadequate translation of omics research into clinical practice. Results Despite significant growth in omics research in both medicine and dentistry, its translation into routine clinical practice in dentistry remains limited. We summarise recent breakthroughs in omics and highlight the gap between research advancements and clinical implementation. Discussion and conclusion The integration of omics approaches holds promise for enhancing diagnostics, personalised treatment strategies, and preventive measures in dental practice, ushering in a new era of precision oral healthcare. However, several challenges, including infrastructure limitations, cost-effectiveness, and education gaps, hinder the widespread adoption of omics-based approaches in clinical dentistry. A strong commitment to transforming dentistry is required to embrace this transition. This shift has the potential to revolutionise oral healthcare by advancing precision diagnostics and treatment strategies tailored to individual patient needs.

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Harnessing Omics Sciences and Biotechnologies in Understanding Osseointegration— Personalized Dental Implant Therapy

Cited by 10 publications

References 0 publications

Implications of considering peri‐implant bone loss a disease, a narrative review

Implications of considering peri‐implant bone loss a disease, a narrative review

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

Bridging the gap between omics research and dental practice

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