Harnessing Nucleic Acids Nanotechnology for Bone/Cartilage Regeneration

Han, Yafei; Cao, Liehu; Li, Guangfeng; Zhou, Fengjin; Bai, Long; Su, Jiacan

doi:10.1002/smll.202301996

Cited by 10 publications

(2 citation statements)

References 210 publications

(305 reference statements)

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“…In addition, the dense ECM limits chondrocyte migration and nutrient diffusion towards the injured area [136]. Conventional treatments (osteochondral autografts or allografts) show limited therapeutic efficacy in many cases and may also lead to post-traumatic osteoarthritis [137]. The development of engineered cartilage usually combines cells with different kinds of natural or synthetic scaffolds, but this is not easy either due to the unique organization of collagen in the cartilage tissue [138].…”

Section: Bone and Cartilage Regenerationmentioning

confidence: 99%

Advances in Biomedical Applications of Solution Blow Spinning

Carriles,

Nguewa,

González-Gaitano

2023

IJMS

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In recent years, Solution Blow Spinning (SBS) has emerged as a new technology for the production of polymeric, nanocomposite, and ceramic materials in the form of nano and microfibers, with similar features to those achieved by other procedures. The advantages of SBS over other spinning methods are the fast generation of fibers and the simplicity of the experimental setup that opens up the possibility of their on-site production. While producing a large number of nanofibers in a short time is a crucial factor in large-scale manufacturing, in situ generation, for example, in the form of sprayable, multifunctional dressings, capable of releasing embedded active agents on wounded tissue, or their use in operating rooms to prevent hemostasis during surgical interventions, open a wide range of possibilities. The interest in this spinning technology is evident from the growing number of patents issued and articles published over the last few years. Our focus in this review is on the biomedicine-oriented applications of SBS for the production of nanofibers based on the collection of the most relevant scientific papers published to date. Drug delivery, 3D culturing, regenerative medicine, and fabrication of biosensors are some of the areas in which SBS has been explored, most frequently at the proof-of-concept level. The promising results obtained demonstrate the potential of this technology in the biomedical and pharmaceutical fields.

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Section: Bone and Cartilage Regenerationmentioning

confidence: 99%

Advances in Biomedical Applications of Solution Blow Spinning

Carriles,

Nguewa,

González-Gaitano

2023

IJMS

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“…Its extensive application in biomedical research spans biosensing, tissue regeneration, targeted drug delivery, and cancer therapy [ 13 ]. Among them, the use of DNA hydrogels in tissue engineering presents a promising solution, attributed to their biocompatibility biodegradability, and programmability [ 14 , 15 ]. Reported to enhance bone repair, the effectiveness of DNA hydrogels is attributed to their phosphate-rich backbone and adenine content, providing biocompatibility, editability, and structural controllability.…”

Section: Introductionmentioning

confidence: 99%

Heterogeneous DNA hydrogel loaded with Apt02 modified tetrahedral framework nucleic acid accelerated critical-size bone defect repair

Han,

Wu,

Wang

et al. 2024

Bioactive Materials

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Research Progress in Hydrogels for Cartilage Organoids

Li,

Sheng,

et al. 2024

Adv Healthcare Materials

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The repair and regeneration of cartilage has always been a hot topic in medical research. Cartilage organoids (CORGs) are special cartilage tissue created using tissue engineering techniques outside the body. These engineered organoids tissues provide models that simulate the complex biological functions of cartilage, opening new possibilities for cartilage regenerative medicine and treatment strategies. However, it is crucial to establish suitable matrix scaffolds for the cultivation of CORGs. In recent years, utilizing hydrogel to culture stem cells and induce their differentiation into chondrocytes has emerged as a promising method for the in vitro construction of CORGs. In this review, we summarize the methods for establishing CORGs and provide an overview of the advantages and limitations of using matrigel in the cultivation of such organoids. Furthermore, we discuss the importance of cartilage tissue extracellular matrix (ECM) and alternative hydrogel substitutes for Matrigel, such as alginate, peptides, silk fibroin, and DNA derivatives, and outline the pros and cons of using these hydrogels for the cultivation of CORGs. Finally, we discuss the challenges and future directions in hydrogel research for CORGs. It is our hope that this article provides valuable references for the design and development of hydrogels for CORGs.This article is protected by copyright. All rights reserved

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Harnessing Nucleic Acids Nanotechnology for Bone/Cartilage Regeneration

Cited by 10 publications

References 210 publications

Advances in Biomedical Applications of Solution Blow Spinning

Advances in Biomedical Applications of Solution Blow Spinning

Heterogeneous DNA hydrogel loaded with Apt02 modified tetrahedral framework nucleic acid accelerated critical-size bone defect repair

Research Progress in Hydrogels for Cartilage Organoids

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