Harnessing mesenchymal aggregation for engineered organ‐level regeneration: Recent progress and perspective
Chen‐Xi Zheng,
Bing‐Dong Sui,
Yan Jin
Abstract:Stem cells, especially mesenchymal progenitors or mesenchymal stem cells (MSCs), possess an intrinsic property to form compact spheroid‐like assemblies, a phenomenon known as cell aggregation. In recent years, a growing body of researches have uncovered that this is a cross‐species conserved developmental event essential for initiating organogenesis in a variety of organs. Moreover, the self‐assembly property also contributes to the regenerative capacities of MSC aggregates in vivo with broad range of applicat… Show more
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