Harnessing liquid biopsies: Exosomes and ctDNA as minimally invasive biomarkers for precision cancer medicine

Bamodu, Oluwaseun Adebayo; Chung, Chen-Chih; Pisanic, Thomas R.

doi:10.1016/j.jlb.2023.100126

Cited by 6 publications

(1 citation statement)

References 99 publications

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“…As the field progresses, it is imperative to address these challenges with diligence and innovation to harness the full potential of liquid biopsy technology across all relevant biofluids 53 . As we navigate the complexities of liquid biopsy, Figure 2 provides a visual synopsis of the multifaceted challenges and limitations encountered across different biofluids.…”

Section: Challenges and Limitations In Diverse Biopsy Fluidsmentioning

confidence: 99%

Beyond blood: Advancing the frontiers of liquid biopsy in oncology and personalized medicine

Bao,

Zhang,

Guo

et al. 2024

Cancer Science

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Liquid biopsy is emerging as a pivotal tool in precision oncology, offering a noninvasive and comprehensive approach to cancer diagnostics and management. By harnessing biofluids such as blood, urine, saliva, cerebrospinal fluid, and pleural effusions, this technique profiles key biomarkers including circulating tumor DNA, circulating tumor cells, microRNAs, and extracellular vesicles. This review discusses the extended scope of liquid biopsy, highlighting its indispensable role in enhancing patient outcomes through early detection, continuous monitoring, and tailored therapy. While the advantages are notable, we also address the challenges, emphasizing the necessity for precision, cost‐effectiveness, and standardized methodologies in its broader application. The future trajectory of liquid biopsy is set to expand its reach in personalized medicine, fueled by technological advancements and collaborative research.

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Section: Challenges and Limitations In Diverse Biopsy Fluidsmentioning

confidence: 99%

Beyond blood: Advancing the frontiers of liquid biopsy in oncology and personalized medicine

Bao,

Zhang,

Guo

et al. 2024

Cancer Science

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New paradigms to break barriers in early cancer detection for improved prognosis and treatment outcomes

Ahmad,

Jasim,

Sharma

et al. 2024

The Journal of Gene Medicine

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The uncontrolled growth and spread of cancerous cells beyond their usual boundaries into surrounding tissues characterizes cancer. In developed countries, cancer is the leading cause of death, while in underdeveloped nations, it ranks second. Using existing cancer diagnostic tools has increased early detection rates, which is crucial for effective cancer treatment. In recent decades, there has been significant progress in cancer‐specific survival rates owing to advances in cancer detection and treatment. The ability to accurately identify precursor lesions is a crucial aspect of effective cancer screening programs, as it enables early treatment initiation, leading to lower long‐term incidence of invasive cancer and improved overall prognosis. However, these diagnostic methods have limitations, such as high costs and technical challenges, which can make accurate diagnosis of certain deep‐seated tumors difficult. To achieve accurate cancer diagnosis and prognosis, it is essential to continue developing cutting‐edge technologies in molecular biology and cancer imaging.

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Applications of dielectrophoresis in microfluidic-based exosome separation and detection

Lan,

Yang

2024

Chemical Engineering Journal

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Harnessing liquid biopsies: Exosomes and ctDNA as minimally invasive biomarkers for precision cancer medicine

Cited by 6 publications

References 99 publications

Beyond blood: Advancing the frontiers of liquid biopsy in oncology and personalized medicine

Beyond blood: Advancing the frontiers of liquid biopsy in oncology and personalized medicine

New paradigms to break barriers in early cancer detection for improved prognosis and treatment outcomes

Applications of dielectrophoresis in microfluidic-based exosome separation and detection

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