Harnessing Inorganic Nanoparticles to Direct Macrophage Polarization for Skeletal Muscle Regeneration

Corsi, Francesca; Carotenuto, Felicia; Nardo, Paolo Di; Teodori, Laura

doi:10.3390/nano10101963

Cited by 8 publications

(10 citation statements)

References 63 publications

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“…Consistently, an imbalanced M1 to M2 polarization impairs skeletal muscle repair (Kharraz et al, 2013 ). Interestingly, recent works have shown that some inorganic NPs such as gold, titanium oxide and cerium oxide NPs may act as immunomodulators, through a mechanism involving macrophage polarization (Corsi et al, 2020 ). Although further studies are necessary to address the therapeutic relevance of these nanosystems, they may represent a promising tool for skeletal muscle disorders ( Figure 4 ) .…”

Section: Nanocarriers As Drug and Gene Delivery Systems In Muscle Dis...mentioning

confidence: 99%

Nanomedicine, a valuable tool for skeletal muscle disorders: Challenges, promises, and limitations

Colapicchioni

Millozzi

Parolini

et al. 2022

WIREs Nanomed Nanobiotechnol

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Muscular dystrophies are a group of rare genetic disorders characterized by progressive muscle weakness, which, in the most severe forms, leads to the patient's death due to cardiorespiratory problems. There is still no cure available for these diseases and significant effort is being placed into developing new strategies to either correct the genetic defect or to compensate muscle loss by stimulating skeletal muscle regeneration. However, the vast anatomical extension of the target tissue poses great challenges to these goals, highlighting the need for complementary strategies. Nanomedicine is an actively evolving field that merges nanotechnologies with biomedical and pharmaceutical sciences. It holds great potential in regenerative medicine, both in supporting tissue engineering and regeneration, and in optimizing drug and oligonucleotide delivery and gene therapy strategies. In this review, we will summarize the state-of-the-art in the field of nanomedicine applied to skeletal muscle regeneration. We will discuss the recent work toward the development of nanopatterned scaffolds for tissue engineering, the efforts in the synthesis of organic and inorganic nanoparticles for gene therapy and drug delivery applications, as well as their use as immune modulators. Although nanomedicine holds great promise for muscle and other degenerative diseases, many challenges still need to be systematically addressed to assure a smooth transition from the bench to the bedside.

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Section: Nanocarriers As Drug and Gene Delivery Systems In Muscle Dis...mentioning

confidence: 99%

Nanomedicine, a valuable tool for skeletal muscle disorders: Challenges, promises, and limitations

Colapicchioni

Millozzi

Parolini

et al. 2022

WIREs Nanomed Nanobiotechnol

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“…A study carried out by Raimondo and Mooney has reported that IL-4-conjugated gold NPs (AuNPs) are efficient in enhancing regeneration of murine skeletal muscle after ischemic injury via modulation of M2 macrophage polarization [ 54 , 70 ]. Ge and colleagues have also shown direct effects of bare AuNPs to stimulate macrophage repolarization for murine skeletal muscle regeneration [ 56 ]. Indeed, they reported that AuNPs significantly enhanced myogenic differentiation of myoblasts promoting in vivo regeneration in models of muscle defects in rats.…”

Section: Nps To Stimulate Tissue Repair and Regenerationmentioning

confidence: 99%

“…TiO 2 nanotubes have been reported to promote osteogenesis via crosstalk between macrophages and mesenchymal stem cells (MSCs) under oxidative stress, stimulation of M1 to M2 macrophage transition and reduction of early inflammation [ 56 ]. Mesoporous silica NPs (MSNs) have been employed to inhibit the inflammatory response and to enhance the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMDMs) through their immunomodulatory effects on macrophages [ 57 ].…”

Section: Nps To Stimulate Tissue Repair and Regenerationmentioning

confidence: 99%

Nanoparticles to Target and Treat Macrophages: The Ockham’s Concept?

2021

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Nanoparticles are nanomaterials with three external nanoscale dimensions and an average size ranging from 1 to 1000 nm. Nanoparticles have gained notoriety in technological advances due to their tunable physical, chemical, and biological characteristics. However, the administration of functionalized nanoparticles to living beings is still challenging due to the rapid detection and blood and tissue clearance by the mononuclear phagocytic system. The major exponent of this system is the macrophage. Regardless the nanomaterial composition, macrophages can detect and incorporate foreign bodies by phagocytosis. Therefore, the simplest explanation is that any injected nanoparticle will be probably taken up by macrophages. This explains, in part, the natural accumulation of most nanoparticles in the spleen, lymph nodes, and liver (the main organs of the mononuclear phagocytic system). For this reason, recent investigations are devoted to design nanoparticles for specific macrophage targeting in diseased tissues. The aim of this review is to describe current strategies for the design of nanoparticles to target macrophages and to modulate their immunological function involved in different diseases with special emphasis on chronic inflammation, tissue regeneration, and cancer.

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“…Consequently, an alternative line of research is based on the concept that the exclusive administration of cell secretome can harness cardiac endogenous repair pathways leading to both stimulation of angiogenesis and mitigation of inflammation and fibrosis [26]. Factors of cell secretome could also be incorporated into biomaterial-based microparticles that allow their prolonged release in order to extend the exposure time of the cardiac tissue [29,30] (Fig. 1).…”

Section: Cells As Therapeutic Agentsmentioning

confidence: 99%

Cardiac Regeneration: the Heart of the Issue

2021

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Purpose of Review The regenerative capacity of the heart is insufficient to compensate for the pathological loss of cardiomyocytes during a large injury, such as a myocardial infarction. Therapeutic options for patients after cardiac infarction are limited: treatment with drugs that only treat the symptoms or extraordinary measures, such as heart transplantation. Cell therapies offer a promising strategy for cardiac regeneration. In this brief review, the major issues in these areas are discussed, and possible directions for future research are indicated. Recent Findings Cardiac regeneration can be obtained by at least two strategies: the first is direct to generate an ex vivo functional myocardial tissue that replaces damaged tissue; the second approach aims to stimulate endogenous mechanisms of cardiac repair. However, current cell therapies are still hampered by poor translation into actual clinical applications. Summary In this scenario, recent advancements in cell biology and biomaterial-based technologies can play a key role to design effective therapeutic approaches.

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Harnessing Inorganic Nanoparticles to Direct Macrophage Polarization for Skeletal Muscle Regeneration

Cited by 8 publications

References 63 publications

Nanomedicine, a valuable tool for skeletal muscle disorders: Challenges, promises, and limitations

Nanomedicine, a valuable tool for skeletal muscle disorders: Challenges, promises, and limitations

Nanoparticles to Target and Treat Macrophages: The Ockham’s Concept?

Cardiac Regeneration: the Heart of the Issue

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