Harnessing electromagnetic fields to assist bone tissue engineering

Zhao, Hongqi; Liu, Chaoxu; Liu, Yang; Ding, Qingqing; Wang, Tianqi; Li, Hao; Wu, Hua; Ma, Tian

doi:10.1186/s13287-022-03217-z

Cited by 16 publications

(10 citation statements)

References 199 publications

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“…With the continuous development of biomechanics, the fnite element method is gradually applied to various felds, and bone stress analysis is one of the main application felds of FEM [13,14]. In this study, the results of FEM analysis can not only explain the biomechanical mechanism of nasomaxillary complex injury [15] but also provide some theoretical guidance for nasomaxillary complex injury in future clinical diagnosis and treatment. In this study, the stress of nasal trauma was simulated and analyzed by the fnite element method [16].…”

Section: Discussionmentioning

confidence: 99%

Establishment of a Finite Element Model of Normal Nasal Bone and Analysis of Its Biomechanical Characteristics

Zhang

Wang

Sun

et al. 2023

Emergency Medicine International

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Nasal bone is a long, paired series of small bones, which is narrow at the top and broad at the bottom, that forms the base of the nasal dorsum. Together with the nasal part of the frontal bone, the frontal process of the maxilla and the middle plate of the ethmoid bone constitute the bone scaffold of the external nose. In this paper, the DICOM image data file was imported into the Mimics software for 3D reconstruction. At the same time, the Geomagic software was used for relevant image processing, and the finite element software ANSYS was used to establish a finite element model to analyze the stress characteristics of the nasomaxillary complex. Results. The maximum principal stress and maximum strain force at the lower segment of nasal bone and the junction of nasal bone and maxilla were relatively large. When the same external force acts on the lower segment of the nasal bone and the angle is 0° (sagittal force), the maximum principal stress and maximum strain force are the smallest. When the angle continues to increase, the maximum principal stress and maximum strain force continue to increase.

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Section: Discussionmentioning

confidence: 99%

Establishment of a Finite Element Model of Normal Nasal Bone and Analysis of Its Biomechanical Characteristics

Zhang

Wang

Sun

et al. 2023

Emergency Medicine International

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“…Even though those devices can be intraorally placed, the oral environment may cause the electric source corruption and the release of toxic chemical substances. A promising solution is coupling the EStim with tissue engineering [ 225 ]. A predictable approach involves applying the EStim to treat cell-scaffold constructs before implantation, which can greatly improve outcome in tissue engineering treatments.…”

Section: Exogenous Electric Stimulationmentioning

confidence: 99%

Bioelectricity in dental medicine: a narrative review

Min,

Gao,

Wang

2024

BioMed Eng OnLine

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Background Bioelectric signals, whether exogenous or endogenous, play crucial roles in the life processes of organisms. Recently, the significance of bioelectricity in the field of dentistry is steadily gaining greater attention. Objective This narrative review aims to comprehensively outline the theory, physiological effects, and practical applications of bioelectricity in dental medicine and to offer insights into its potential future direction. It attempts to provide dental clinicians and researchers with an electrophysiological perspective to enhance their clinical practice or fundamental research endeavors. Methods An online computer search for relevant literature was performed in PubMed, Web of Science and Cochrane Library, with the keywords “bioelectricity, endogenous electric signal, electric stimulation, dental medicine.” Results Eventually, 288 documents were included for review. The variance in ion concentration between the interior and exterior of the cell membrane, referred to as transmembrane potential, forms the fundamental basis of bioelectricity. Transmembrane potential has been established as an essential regulator of intercellular communication, mechanotransduction, migration, proliferation, and immune responses. Thus, exogenous electric stimulation can significantly alter cellular action by affecting transmembrane potential. In the field of dental medicine, electric stimulation has proven useful for assessing pulp condition, locating root apices, improving the properties of dental biomaterials, expediting orthodontic tooth movement, facilitating implant osteointegration, addressing maxillofacial malignancies, and managing neuromuscular dysfunction. Furthermore, the reprogramming of bioelectric signals holds promise as a means to guide organism development and intervene in disease processes. Besides, the development of high-throughput electrophysiological tools will be imperative for identifying ion channel targets and precisely modulating bioelectricity in the future. Conclusions Bioelectricity has found application in various concepts of dental medicine but large-scale, standardized, randomized controlled clinical trials are still necessary in the future. In addition, the precise, repeatable and predictable measurement and modulation methods of bioelectric signal patterns are essential research direction. Graphical abstract

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“…EVs have gained significant attention in CNS injuries, specifically traumatic brain injuries (TBI) and spinal cord injuries (SCI), due to their intricate involvement in injury response, repair processes, and their potential applications as therapeutic agents and biomarkers [175][176][177]. CNS-derived EVs are rich in cell-specific surface markers and contain diverse intraluminal contents, including proteins, RNA, DNA, and metabolites.…”

Section: Cns Injuriesmentioning

confidence: 99%

Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions

Choi,

Chen,

Goldston

et al. 2024

Nano Convergence

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Central Nervous System (CNS) disorders represent a profound public health challenge that affects millions of people around the world. Diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and traumatic brain injury (TBI) exemplify the complexities and diversities that complicate their early detection and the development of effective treatments. Amid these challenges, the emergence of nanotechnology and extracellular vesicles (EVs) signals a new dawn for treating and diagnosing CNS ailments. EVs are cellularly derived lipid bilayer nanosized particles that are pivotal in intercellular communication within the CNS and have the potential to revolutionize targeted therapeutic delivery and the identification of novel biomarkers. Integrating EVs with nanotechnology amplifies their diagnostic and therapeutic capabilities, opening new avenues for managing CNS diseases. This review focuses on examining the fascinating interplay between EVs and nanotechnology in CNS theranostics. Through highlighting the remarkable advancements and unique methodologies, we aim to offer valuable perspectives on how these approaches can bring about a revolutionary change in disease management. The objective is to harness the distinctive attributes of EVs and nanotechnology to forge personalized, efficient interventions for CNS disorders, thereby providing a beacon of hope for affected individuals. In short, the confluence of EVs and nanotechnology heralds a promising frontier for targeted and impactful treatments against CNS diseases, which continue to pose significant public health challenges. By focusing on personalized and powerful diagnostic and therapeutic methods, we might improve the quality of patients.

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Harnessing electromagnetic fields to assist bone tissue engineering

Cited by 16 publications

References 199 publications

Establishment of a Finite Element Model of Normal Nasal Bone and Analysis of Its Biomechanical Characteristics

Establishment of a Finite Element Model of Normal Nasal Bone and Analysis of Its Biomechanical Characteristics

Bioelectricity in dental medicine: a narrative review

Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions

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