Harnessing Diazoketones for the Efficient Synthesis of 2,4-Disubstituted-(1,3)Thiazoles: Scalable and Versatile Approach to Important Heterocyclic Scaffolds

Abstract

This study presents a scalable one-pot synthesis of 2,4-disubstituted-(1,3)thiazoles using diazoketones with thiosemicarbazide or thiourea, achieving high yields across various substrates. Thiazole derivatives demonstrate diverse biological activities (antibacterial, antiviral, anticancer, etc.) and applications in nanoelectronics and material science The suggested approach to their preparation highlights diazoketones as a chemically resilient alternative to traditionally used halogen ketones. This versatile synthesis method expands the scope of available 2,4-disubstituted-(1,3)thiazoles and opens broad opportunities for this class of compounds to contribute to advancements in medicinal chemistry and technology on the next level.