Harnessing bacteria for tumor therapy: Current advances and challenges

Guo, Lin; Ding, Jinsong; Zhou, Wenhu

doi:10.1016/j.cclet.2023.108557

Cited by 10 publications

(5 citation statements)

References 125 publications

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“…Busch observed tumor regression in cancer patients after infection with erysipelas, and Fehleisen identified Streptococcus pyogenes as the causative agent of erysipelas infection. Afterward, Coley developed the first cancer immunotherapy drug ("Coley toxin") based on heat-killed bacteria [151]. Over 1000 patients, many or most of whom had sarcomas, exhibited degenerative changes and cures.…”

Section: Immunotherapymentioning

confidence: 99%

Role of the gut microbiota in tumorigenesis and treatment

Liu,

Yang,

Pan

et al. 2024

Theranostics

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The gut microbiota is a crucial component of the intricate microecosystem within the human body that engages in interactions with the host and influences various physiological processes and pathological conditions. In recent years, the association between dysbiosis of the gut microbiota and tumorigenesis has garnered increasing attention, as it is recognized as a hallmark of cancer within the scientific community. However, only a few microorganisms have been identified as potential drivers of tumorigenesis, and enhancing the molecular understanding of this process has substantial scientific importance and clinical relevance for cancer treatment. In this review, we delineate the impact of the gut microbiota on tumorigenesis and treatment in multiple types of cancer while also analyzing the associated molecular mechanisms. Moreover, we discuss the utility of gut microbiota data in cancer diagnosis and patient stratification. We further outline current research on harnessing microorganisms for cancer treatment while also analyzing the prospects and challenges associated with this approach.

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Section: Immunotherapymentioning

confidence: 99%

Role of the gut microbiota in tumorigenesis and treatment

Liu,

Yang,

Pan

et al. 2024

Theranostics

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“…Despite considerable progress in the field of bacteria-based anticancer therapy, there are still many unanswered questions regarding the use of bacteria for antineoplastic purposes [217]. For example, the intrinsic bacterial immunogenicity and toxicity represent a safety risk for oncological patients due to the proliferation capacity of live bacteria and the potential to lead to systemic inflammation and septic shock.…”

Section: Microbiota As a Therapeutic Targetmentioning

confidence: 99%

Friend or Foe: Exploring the Relationship between the Gut Microbiota and the Pathogenesis and Treatment of Digestive Cancers

Profir,

Roşu,

Creţoiu

et al. 2024

Microorganisms

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Digestive cancers are among the leading causes of cancer death in the world. However, the mechanisms of cancer development and progression are not fully understood. Accumulating evidence in recent years pointing to the bidirectional interactions between gut dysbiosis and the development of a specific type of gastrointestinal cancer is shedding light on the importance of this “unseen organ”—the microbiota. This review focuses on the local role of the gut microbiota imbalance in different digestive tract organs and annexes related to the carcinogenic mechanisms. Microbiota modulation, either by probiotic administration or by dietary changes, plays an important role in the future therapies of various digestive cancers.

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“…Bacteria at the tumor site can stimulate the immune system to produce a series of anticancer immune responses is another advantage of bacterial carriers in cancer therapy. This is because bacteria carry a large number of antigens such as lipopolysaccharide and flagellin, which can bind to toll-like receptors and, thus, trigger a series of cellular signaling events [ 47 , 48 , 49 ]. The mechanisms by which bacteria activate anticancer immunity in the body are complex and interact with each other.…”

Section: The Advantages and Mechanisms Of Bacteria For Cancer Therapymentioning

confidence: 99%

Bacterial Drug Delivery Systems for Cancer Therapy: “Why” and “How”

Zhao,

Xie,

Zhang

et al. 2023

Pharmaceutics

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Cancer is one of the major diseases that endanger human health. However, the use of anticancer drugs is accompanied by a series of side effects. Suitable drug delivery systems can reduce the toxic side effects of drugs and enhance the bioavailability of drugs, among which targeted drug delivery systems are the main development direction of anticancer drug delivery systems. Bacteria is a novel drug delivery system that has shown great potential in cancer therapy because of its tumor-targeting, oncolytic, and immunomodulatory properties. In this review, we systematically describe the reasons why bacteria are suitable carriers of anticancer drugs and the mechanisms by which these advantages arise. Secondly, we outline strategies on how to load drugs onto bacterial carriers. These drug-loading strategies include surface modification and internal modification of bacteria. We focus on the drug-loading strategy because appropriate strategies play a key role in ensuring the stability of the delivery system and improving drug efficacy. Lastly, we also describe the current state of bacterial clinical trials and discuss current challenges. This review summarizes the advantages and various drug-loading strategies of bacteria for cancer therapy and will contribute to the development of bacterial drug delivery systems.

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Harnessing bacteria for tumor therapy: Current advances and challenges

Cited by 10 publications

References 125 publications

Role of the gut microbiota in tumorigenesis and treatment

Role of the gut microbiota in tumorigenesis and treatment

Friend or Foe: Exploring the Relationship between the Gut Microbiota and the Pathogenesis and Treatment of Digestive Cancers

Bacterial Drug Delivery Systems for Cancer Therapy: “Why” and “How”

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