Harnessing Aromatic‐Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification
Zhen Yu,
Dale F. Kreitler,
Yin Ting T. Chiu
et al.
Abstract:Peptide engineering efforts have delivered drugs for diverse human diseases. Side chain alteration is among the most common approaches to designing new peptides for specific applications. The peptide backbone can be modified as well, but this strategy has received relatively little attention. Here we show that new and favorable contacts between a His side chain on a target protein and an aromatic side chain on a synthetic peptide ligand can be engineered by rational and coordinated side chain modification and … Show more
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