Harnessing alcohols as sustainable reagents for late-stage functionalisation: synthesis of drugs and bio-inspired compounds

Abstract

This review collectively discussed the utilisation of alcohols in various organic transformations and their application toward intermediates of drugs, drug derivatives and natural product-like molecules.

Nickel-Catalyzed Cyanation of Allylic Alcohols: High Degree of Chiral Inversion in Aqueous Reaction Media

“…Transition-metal-catalyzed allylic substitution (also known as Tsuji–Trost reaction) represents a powerful method for carbon–carbon and carbon–heteroatom bond formations. , In this field, the use of earth-abundant metals based catalysts, ,, allylic alcohols as electrophiles, ,, and aqueous reaction media , is gaining more attention. Compared with traditional organic solvents, water is naturally available, nontoxic, and more cost-effective.…”