Harmonizing across environmental nanomaterial testing media for increased comparability of nanomaterial datasets

Geitner, Nicholas K.; Hendren, Christine Ogilvie; Cornelis, Geert; Kaegi, Rälf; Lead, Jamie R.; Lowry, Gregory V.; Lynch, Iseult; Nowack, Bernd; Petersen, Elijah J.; Bernhardt, Emily S.; Brown, Scott C.; Chen, Wei; Garidel-Thoron, Camille de; Hanson, Jaydee; Harper, Stacey L.; Jones, K. M.; Kammer, Frank von der; Kennedy, Alan J.; Kidd, Justin; Matson, Cole W.; Metcalfe, Chris D.; Pedersen, Joel A.; Peijnenburg, Willie J.G.M.; Quik, J.T.K.; Rodrigues, Sónia; Rose, Jérôme; Sayre, Phil; Simonin, Marie; Svendsen, Claus; Tanguay, Robert L.; Tefenkji, Nathalie; Teunenbroek, Tom van; Thies, Gregory; Tian, Yuan; Rice, Jacelyn; Turner, Amalia; Liu, Jie; Unrine, Jason M.; Vance, Marina E.; White, Jason C.; Wiesner, Mark R.

doi:10.1039/c9en00448c

Cited by 35 publications

(20 citation statements)

References 128 publications

(144 reference statements)

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“…In general, nanomaterial surfaces have high free energy; therefore, thermodynamic driving forces act to minimize the surface energy, and consequently, nanomaterials will suffer physical and chemical transformations, such as dissolution, agglomeration, and surface chemistry modifications, upon interaction with biological and environmental media. All these transformations are dependent on medium composition and exposure conditions, including solution pH, ionic strength and composition [ 22 , 50 ]. The synthetized GO shows a high dispersion stability in ultrapure water up to 72 h, monitored by UV–VIS and DLS measurements ( Figure S2, supplementary information ).…”

Section: Resultsmentioning

confidence: 99%

“…Data interoperability is especially important in a regulatory context, where standardised guidelines (e.g., OECD, ISO) need to be followed during experimental practice and becomes even more prominent as computational tools and workflows come into the picture. As a result, protocol and medium harmonisation are of the utmost importance as several cytotoxicity meta-analysis studies have stressed and demonstrated a significant correlation between the type of assay and medium used and the resulting hazardous effects [ 20 , 21 , 22 ]. To achieve this, the Horizon 2020 e-infrastructure project NanoCommons ( ) has been developing a cloud-based Knowledge Base, which links nano-related databases, and provides data curation and storage solutions linking information about the nanomaterials, their medium or environmental conditions and the overall test conditions to the resulting effect data, enabling tracking of changes to the particles over the experimental timeframe.…”

Section: Introductionmentioning

confidence: 99%

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Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to Daphnia magna and Integration of the Datasets into the NanoCommons Knowledge Base

et al. 2020

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In this work, we evaluated the effect of protein corona formation on graphene oxide (GO) mixture toxicity testing (i.e., co-exposure) using the Daphnia magna model and assessing acute toxicity determined as immobilisation. Cadmium (Cd2+) and bovine serum albumin (BSA) were selected as co-pollutant and protein model system, respectively. Albumin corona formation on GO dramatically increased its colloidal stability (ca. 60%) and Cd2+ adsorption capacity (ca. 4.5 times) in reconstituted water (Daphnia medium). The acute toxicity values (48 h-EC50) observed were 0.18 mg L−1 for Cd2+-only and 0.29 and 0.61 mg L−1 following co-exposure of Cd2+ with GO and BSA@GO materials, respectively, at a fixed non-toxic concentration of 1.0 mg L−1. After coronation of GO with BSA, a reduction in cadmium toxicity of 110 % and 238% was achieved when compared to bare GO and Cd2+-only, respectively. Integration of datasets associated with graphene-based materials, heavy metals and mixture toxicity is essential to enable re-use of the data and facilitate nanoinformatics approaches for design of safer nanomaterials for water quality monitoring and remediation technologies. Hence, all data from this work were annotated and integrated into the NanoCommons Knowledge Base, connecting the experimental data to nanoinformatics platforms under the FAIR data principles and making them interoperable with similar datasets.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to Daphnia magna and Integration of the Datasets into the NanoCommons Knowledge Base

et al. 2020

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“…Finally, it is also important to adequately characterize the exposure‐water chemistry in nano‐Ni toxicity tests, because dissolved Ni released from nano‐Ni can sometimes reach or exceed toxic concentrations in some water chemistries (Geitner et al 2020; and see Source of nano‐Ni toxicity: Nano‐Ni particles or dissolved Ni? ).…”

Section: Resultsmentioning

confidence: 99%

Toxicity of Nanoparticulate Nickel to Aquatic Organisms: Review and Recommendations for Improvement of Toxicity Tests

Meyer¹,

Lyons-Darden²,

Garman³

et al. 2020

Enviro Toxic and Chemistry

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We reviewed the literature on toxicity of nanoparticulate nickel (nano-Ni) to aquatic organisms, from the perspective of relevance and reliability in a regulatory framework. Our main findings were 1) much of the published nano-Ni toxicity data is of low or medium quality in terms of reporting key physical-chemical properties, methodologies, and results, compared with published dissolved nickel studies; and 2) based on the available information, some common findings about nanoparticle (NP) toxicity are not supported for nano-Ni. First, we concluded that nanoparticulate elemental nickel and nickel oxide, which differ in chemical composition, generally did not differ in their toxicity. Second, there is no evidence that the toxicity of nano-Ni increases as the size of the NPs decreases. Third, for most organisms tested, nano-Ni was not more toxic on a mass-concentration basis than dissolved Ni. Fourth, there is conflicting evidence about whether the toxicity is directly caused by the NPs or by the dissolved fraction released from the NPs. However, no evidence suggests that any of the molecular, physiological, and structural mechanisms of nano-Ni toxicity differ from the general pattern for many metal-based nanomaterials, wherein oxidative stress underlies the observed effects. Physical-chemical factors in the design and conduct of nano-Ni toxicity tests are important, but often they are not adequately reported (e.g., characteristics of dry nano-Ni particles and of wetted particles in exposure waters; exposure-water chemistry).

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“…Unfortunately, the key drivers of toxicity in these assessments are not clear in some cases, and the observed effects may be caused by their bulk counterparts and released ions or degradants instead of the nanomaterials themselves. Therefore, the selection of appropriate methods to identify nanomaterials and differentiate their toxicity from bulk counterparts is imperative (Geitner et al 2020). Such a finding is partially attributable to the fact that there has been increasing evidence to show that many nanomaterials are not consistently more toxic to living organisms when compared with their bulk counterparts (Wiesner 2019).…”

Section: What Are the Terrestrial And Aquatic Risks Of Atmospheric Comentioning

confidence: 99%

Toward Sustainable Environmental Quality: Priority Research Questions for Asia

Leung

Yeung

You

et al. 2020

Enviro Toxic and Chemistry

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Harmonizing across environmental nanomaterial testing media for increased comparability of nanomaterial datasets

Abstract: The chemical composition and properties of

Cited by 35 publications

References 128 publications

Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to Daphnia magna and Integration of the Datasets into the NanoCommons Knowledge Base

Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to Daphnia magna and Integration of the Datasets into the NanoCommons Knowledge Base

Toxicity of Nanoparticulate Nickel to Aquatic Organisms: Review and Recommendations for Improvement of Toxicity Tests

Toward Sustainable Environmental Quality: Priority Research Questions for Asia

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