Harmonization in hemolysis detection and prevention. A working group of the Catalonian Health Institute (ICS) experience

Abstract

The setting of interference limits (cut-off) for each used test/method, and the study of preanalytical variability will assist to the results harmonization for this quality indicator.

Croatian laboratories have a good knowledge of the proper detection and management of hemolyzed, icteric and lipemic samples

“…It has already been documented that manufacturer's information can be inaccurate, incomplete and sometimes not replicated in the laboratory. Recently we Brought to you by | McMaster University Authenticated Download Date | 10/6/15 11:53 AM have published these findings for the lipemia interference from three different manufacturers [27] and Spanish group of authors confirmed similar findings for the hemolysis on five different analytical systems [25]. Participants from accredited laboratories probably reached similar conclusions while performing verification experiments as requested by the ISO 15189 [34].…”

“…There is no increase in cost or turn-aroundtime and standardized management of unsuitable samples in achieved across the laboratories. Although there are some potential issues with serum indices, such as false positive results [24], heterogeneity between manufacturers in sensitivity and methods of detection [25], serum indices measurement is currently the optimal way of assessing hemolysis, lipemia and icteria. Based on the results of our study, management of lipemic and icteric samples is not adequate among laboratory specialists in Croatia.…”

Making sense of a haemolysis monitoring and reporting system: a nationwide longitudinal multimethod study of 68 Australian laboratory participant organisations

“…A considerable variation in haemolysis rates reported in the literature was identified. Seven studies reported a haemolysis rejection below 1% of all accessions [17][18][19][20][21][22][23], six between 1% and 3% [24][25][26][27][28][29], 20 between 3% and 20% [9,[30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] and another four above 20% [49][50][51][52]. Haemolysis detection methods, and free plasma haemoglobin levels used for this detection, are likely to be partly responsible for this variation, in addition to the differences in study designs and study populations.…”

Evaluación multicéntrica de materiales para el control de calidad de los índices séricos

“…Es este un defecto importante ya que dicho grado de hemólisis es capaz de generar interferencias significativas en la medición de diversas magnitudes biológicas 17 .…”