Harmful Free Radicals in Aging: A Narrative Review of Their Detrimental Effects on Health

Mustafa, Yasser Fakri

doi:10.1007/s12291-023-01147-y

Cited by 25 publications

(4 citation statements)

References 106 publications

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“…Antioxidants have been reported to protect the skin against UV-induced damage [18], reduce collagen degradation [19], reduce inflammation [19], and thereby enhance the skin's barrier function, resulting in more skin vitality and youthful-looking skin, as well as Oxidative stress is a primary contributor to skin aging, leading to the formation of wrinkles and other signs of aging [15]. Antioxidants play a vital role in skin rejuvenation by neutralizing harmful free radicals and reducing oxidative damage to skin cells [16,17]. Antioxidants have been reported to protect the skin against UV-induced damage [18], reduce collagen degradation [19], reduce inflammation [19], and thereby enhance the skin's barrier function, resulting in more skin vitality and youthful-looking skin, as well as diminished visible signs of aging and maintenance.…”

Section: Antioxidant and Hyaluronidase Inhibitory Activities Of Natur...mentioning

confidence: 99%

Clinical Efficacy in Skin Hydration and Reducing Wrinkles of Nanoemulsions Containing Macadamia integrifolia Seed Oil

Somwongin,

Chaiyana

2024

Nanomaterials

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This study aimed to assess natural oils for their antioxidant and anti-hyaluronidase properties and select the most effective candidate for development into nanoemulsions (NE) for clinical evaluations. The oils were assessed using 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS•+) and ferric thiocyanate assays for antioxidant properties and an enzyme-substrate reaction assay for anti-hyaluronidase activity. The most potent oil was formulated into conventional emulsions (CE) and NE, which were characterized and evaluated for their stability, both in accelerated and long-term conditions. The irritation potential was assessed using both the hen’s eggs chorioallantoic membrane test and a clinical trial. Skin hydration enhancement and skin wrinkle reduction efficacy were clinically assessed. Macadamia integrifolia oil exhibited significant potency as an ABTS•+ radical scavenger, lipid peroxidation inhibitor, and hyaluronidase inhibitor (p < 0.05). Both the CE and NE, comprising 15% w/w oil, 5% w/w Tween® 80 and Span® 80, and 80% w/w DI water, were found to be optimal. NE with an internal droplet size of 112.4 ± 0.8 nm, polydispersity index of 0.17 ± 0.01, and zeta potential of −31.5 ± 1.0 mV, had good stability and induced no irritation. Both CE and NE enhanced skin hydration and reduced skin wrinkles in human volunteers, while NE was outstanding in skin hydration enhancement.

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Section: Antioxidant and Hyaluronidase Inhibitory Activities Of Natur...mentioning

confidence: 99%

Clinical Efficacy in Skin Hydration and Reducing Wrinkles of Nanoemulsions Containing Macadamia integrifolia Seed Oil

Somwongin,

Chaiyana

2024

Nanomaterials

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“…Additionally, epigenomic changes greatly affect cellular function and profoundly contribute to aging progression ( 1 ). Also, scientific evidence has indicated the free radical reactions that occur within the cells and tissues, representing the major contributor to the aging process ( 2 , 3 ). Indeed, understanding the underpinning mechanisms is critical for developing effective strategies against age-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Profiling of Petroselinum sativum (mill.) fuss phytoconstituents and assessment of their biocompatibility, antioxidant, anti-aging, wound healing, and antibacterial activities

Mahdi,

Imbimbo,

Annaz

et al. 2024

Front. Nutr.

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Petroselinum sativum, known as parsley, is a fragrant herb that possesses a rich heritage of utilization in traditional medicinal practices. In this study, we annotated the phytocontents of the aqueous and ethanolic extracts of P. sativum and investigated their antioxidant, cytoprotective, antiaging, wound healing, and antibacterial activities. LC–MS/MS analysis of both extracts revealed the presence of 47 compounds belonging to diverse groups including organic acids, phenolic acids, and flavonoids. By MTT assay, the extracts were fully biocompatible on immortalized human keratinocytes (HaCaT) while they inhibited intracellular ROS formation (DCFDA assay) and prevented GSH depletion (DTNB assay) upon UVA exposure. In addition, the extracts were potent in inhibiting the in vitro activities of skin-related enzymes mainly elastase, tyrosinase, collagenase and hyaluronidase. Using the scratch assay, P. sativum aqueous extract significantly enhanced wound closure when compared to untreated HaCaT cells. Moreover, both extracts inhibited Pseudomonas aeruginosa’s growth, reduced biofilm formation, and impaired the swimming and swarming motilities. Also, the aqueous extract was able to inhibit the production of bacterial pigments on plates. These findings strongly suggest the usefulness of P. sativum as a source of phytochemicals suitable for dermo-cosmeceutical applications.

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“…In the field of food production, there is a growing interest in developing products with health-promoting ingredients, such as those with strong antioxidant capacity, to meet consumer demand for the relationship between nutrition and health [9]. Studies have shown that free radicals cause oxidative damage to lipids, proteins, and nucleic acids [10]. Antioxidants play a crucial role in neutralizing these free radicals to prevent diseases, as reported by Chaudhary et al (2023) [11].…”

Section: Introductionmentioning

confidence: 99%

Changes in Biochemical and Bioactive Compounds in Two Red Grape Cultivars during Ripening and Cold Storage

Moradi,

Koushesh Saba,

Sadeghi

et al. 2024

Agronomy

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The market value of grapes (Vitis vinifera L.) is affected by their quality and harvesting time. Veraison and stage of ripening are the most important factors determining table grape quality. Therefore, the present research was performed to determine the effects of various ripening stages on the combination and postharvest quality of two red grape cultivars. Based on color change, fruits were harvested at the veraison stage, two weeks after the veraison stage, and at the full ripening stage. Fruits harvested at the fully ripe stage were stored for 7, 14, and 21 days (at 1 °C with 85–90% relative humidity). The greatest soluble solids content (SSC) (16.1%) and SSC/TA ratio were observed in ‘Khoshnav’, while the greatest titratable acidity (TA) (0.45%) and pH (3.60) were observed in ‘Rashah’. The results of the present study showed that regardless of the storage period, fruits harvested at time V (veraison time) and two weeks after veraison (2WAV) had significantly higher firmness and vitamin C content. ‘Khoshnav’ had the lowest weight loss (2.05%), and ‘Khoshnav’ and ‘Rashah’ had the greatest firmness (5.95 N) and vitamin C content (89.48 mg 100 g−1 FW). The greatest anthocyanin content was observed on day 7 of storage in ‘Rashah’. Total phenol (TP) and total flavonoid (TF) contents and antioxidant capacity (AC) increased significantly until harvest and decreased thereafter during cold storage. ‘Rashah’ showed the greatest AC, TP, and TF values. Based on the findings of this study, the ‘Rashah’ grape cultivar is shown to be rich in vitamin C, anthocyanins, flavonoids, phenolics, and antioxidants. It holds potential for utilization in both processing and breeding programs as a functional food ingredient.

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Harmful Free Radicals in Aging: A Narrative Review of Their Detrimental Effects on Health

Cited by 25 publications

References 106 publications

Clinical Efficacy in Skin Hydration and Reducing Wrinkles of Nanoemulsions Containing Macadamia integrifolia Seed Oil

Clinical Efficacy in Skin Hydration and Reducing Wrinkles of Nanoemulsions Containing Macadamia integrifolia Seed Oil

Profiling of Petroselinum sativum (mill.) fuss phytoconstituents and assessment of their biocompatibility, antioxidant, anti-aging, wound healing, and antibacterial activities

Changes in Biochemical and Bioactive Compounds in Two Red Grape Cultivars during Ripening and Cold Storage

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