Harmful alcohol use among acutely ill hospitalized medical patients in Oslo and Moscow: A cross-sectional study

Kabashi, Saranda; Vindenes, Vigdis; Bryun, Evgeny А.; Koshkina, Evgenia; Nadezhdin, A. V.; Tetenova, Elena; Kolgashkin, Alexey J.; Петухов, А. Е.; Переходов, С. Н.; Davydova, E.V.; Gamboa, Danil; Hilberg, Thor; Lerdal, Anners; Nordby, Gudmund; Zhang, Chi; Bogstrand, Stig Tore

doi:10.1016/j.drugalcdep.2019.107588

Cited by 26 publications

(39 citation statements)

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“…The major limitation of our study is the lack of further clinical information about the patients, which could be utilized to adjust our results, and the lack of data on self‐reported alcohol consumption through, for example, the Alcohol Use Disorders Identification Test (AUDIT). However, previous research has found significant correlation between PEth concentrations and AUDIT, (Afshar et al, 2017; Helander et al, 2019b; Kabashi et al, 2019; Nguyen et al, 2018; Piano et al, 2015; Schröck et al, 2017b). Even though we found a higher sensitivity for PEth compared with CDT, it is beyond the scope of this study to examine PEth in relation to CDT in detecting adverse alcohol consumption due to the lack of a predefined standard in our study, which might have been, for example, monitoring of alcohol consumption among the study participants.…”

Section: Discussionmentioning

confidence: 93%

“…Formation of PEth has been detected in blood within 1 hour after a single dose of 0.4 g/kg EtOH (Hill‐Kapturczak et al, 2018), and a half‐life of four days was observed (Varga et al, 2000). PEth has proved useful in a variety of settings including alcohol detoxification programs, occupational, and pre‐employment medical examination (Neumann et al, 2020), screening in emergency department (Kabashi et al, 2019), detecting heavy drinking among young adults, drug users, HIV‐positive patients (Bajunirwe et al, 2014), as well as for confirming abstinence from alcohol (Schröck et al, 2016).…”

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confidence: 99%

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Comparison of the Diagnostic Value of Phosphatidylethanol and Carbohydrate‐Deficient Transferrin as Biomarkers of Alcohol Consumption

Årving

Høiseth

Hilberg³

et al. 2020

Alcoholism Clin & Exp Res

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Background The aim of this study was to compare the results of Phosphatidylethanol (PEth) and carbohydrate‐deficient transferrin (CDT) in blood as biomarkers of alcohol consumption in a large clinical cohort and to evaluate concentrations in relation to age and sex. Methods Results of PEth 16:0/18:1 in blood and CDT in serum were included, together with information of age and sex, which were extracted from a clinical chemistry database containing samples mostly from patients of primary care physicians and social care institutions. PEth concentrations were determined using Ultra Performance Convergence chromatography mass spectrometer. CDT was quantified by electrophoretic Capillary System. CDT values ≥ 1.7 %‐units and PEth values ≥ 0.31 µmol/L were considered to indicate heavy alcohol consumption. Results Samples from 6705 patients were included. The median age was 54.5 years, and 34 % were females. Only 47 % of the patients with PEth ≥ 0.31 µmol/L had increased CDT ≥ 1.7 %‐units examined in the same specimen (Cohen’s kappa was 0.43, p < 0.001). Patients above 50 years had significantly higher concentrations for both CDT (1.0 %‐units vs. 0.9 %‐units, p < 0.001) and PEth (0.340 µmol/L vs. 0.200 µmol/L, p < 0.001) compared with younger patients. Concentrations of CDT were significantly higher in males compared with females (p = 0.002), while no significant sex differences were seen for PEth (p = 0.465). Conclusions A high fraction of the patients had PEth values above the suggested cutoff for heavy drinking and normal CDT values, verifying the superior sensitivity of PEth compared with CDT. The effect of age seems to be minor for both markers. Higher concentrations of CDT, but not PEth, were seen in males, indicating that PEth, as opposed to CDT, might be formed equally in men and women. Therefore, the bias due to sex is possibly present only for CDT, not for PEth.

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Section: Discussionmentioning

confidence: 93%

mentioning

confidence: 99%

Comparison of the Diagnostic Value of Phosphatidylethanol and Carbohydrate‐Deficient Transferrin as Biomarkers of Alcohol Consumption

Årving

Høiseth

Hilberg³

et al. 2020

Alcoholism Clin & Exp Res

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“…The Disability Adjusted Life Years (DALY) estimate for 2013 was 99,278,000, also reflecting a substantial increase (30.5 %) in global disability related to alcohol use during the same period (Forouzanfar et al, 2015). A recent study of persons admitted to hospital with acute medical Daily use of alcohol 4 illness showed that 19.2 % of the patients in Moscow and 21.1 % of the patients in Oslo used alcohol in a harmful way (Kabashi et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Daily use of alcohol in the Norwegian general population: Prevalence and associated factors

Bonsaksen

Heir

Skogstad

et al. 2020

DAT

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Purpose Harmful use of alcohol is a major public health problem. While harm is often researched in the context of heavy drinking episodes, high-frequency drinking, even when drinking moderate quantities, constitutes a health risk in a longer perspective. The purpose of this paper is to examine the prevalence of daily use of alcohol in the Norwegian general population and to assess sociodemographic, mental health-related and personal resource variables associated with daily use of alcohol. Design/methodology/approach A cross-sectional survey concerned with health, illness and serious life events was distributed to 5,500 persons in the general population in Norway (response rate 36%). Sociodemographic variables, personal resource variables (general self-efficacy, optimism and extraversion) and psychological distress (current anxiety and/or depression) were assessed with regards to their associations with daily drinking in unadjusted and adjusted regression models. Findings Daily use of alcohol was reported by 39 persons (2.2%) in the sample (3.1% of men and 1.4% of women). While general self-efficacy, optimism and extraversion were unrelated to daily drinking, the adjusted model revealed that male sex (OR: 2.18, p < 0.05), being unemployed/not in education (OR: 3.10, p < 0.05) and reporting current anxiety and/or depression (OR: 3.12, p < 0.01) were associated with daily use of alcohol. Originality/value The study has contributed to the knowledge about daily drinkers in a representative sample of the Norwegian population. A proportion of 2.2% was found to drink alcohol on a daily basis. Compared to their counterparts, the odds of daily drinking were higher for men, unemployed persons and persons reporting current psychological distress. Public health initiatives aiming at reducing harmful use of alcohol may pay particular attention to these subsets of the population.

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“…Self-reported alcohol use was measured through the Alcohol Use Disorder Identification Test-4 (AUDIT-4), which has been validated as a simple yet effective screening tool for identifying alcohol use disorders. 24 25 A value of 7 points or more for men and 5 points or more for women indicates at-risk alcohol consumption patterns. Both questionnaires have been validated for use in their respective nations.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of psychoactive substance use among acutely hospitalised patients in Oslo and Moscow: a cross-sectional, observational study

Gamboa

Jørgenrud

Bryun³

et al. 2020

BMJ Open

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ObjectivesThe use of psychoactive prescription medication is increasing in the general population. This is a cause for concern, particularly among the elderly, where physiological changes related to senescence increase the risk for adverse effects. While previous studies regarding psychoactive substance use have generally been population based, we sought to determine the frequency of such use among acutely hospitalised patients.SettingTwo emergency departments (EDs), one in Oslo and one in Moscow, admitting patients to Departments of Internal Medicine.Participants5583 patients aged ≥18 years participated, distributed evenly between genders and study locations. Patients unable to give informed consent were excluded. The study sites did not admit patients with surgical conditions and/or injuries.Primary and secondary outcomesThe presence of psychoactive substances was determined through blood analysis using liquid chromatography-mass spectrometry. Secondary outcomes comprised demographic data (including age, gender, employment and marital status), degree of psychological distress, concurrent alcohol use, and self-reported alcohol, psychoactive drug and illicit substance use.Results32.3% in Oslo and 12% in Moscow were positive for one or more psychoactive medicinal drugs (benzodiazepines, z-hypnotics, opioids or barbiturates). In Oslo, medicinal drug use was associated with being aged 61 to 70 years (OR 2.40, 95% CI 1.61 to 3.58) compared with 18 to 40 years, and psychological distress (OR 2.61, 95% CI 2.06 to 3.30). In Moscow, psychoactive medicinal drug use was also associated with psychological distress (OR 1.68, 95% CI 1.18 to 2.39), and was less common among patients aged 41 to 60 years (OR 0.62, 95% CI 0.43 to 0.88) than among patients aged 18 to 40 years.ConclusionA significant proportion of admitted patients used one or more psychoactive medicinal drugs, in particular benzodiazepines (Oslo and Moscow) and opiates (Oslo). We suggest formalised screening for inappropriate prescription drug use and increased adherence to clinical prescription guidelines.

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Harmful alcohol use among acutely ill hospitalized medical patients in Oslo and Moscow: A cross-sectional study

Cited by 26 publications

References 58 publications

Comparison of the Diagnostic Value of Phosphatidylethanol and Carbohydrate‐Deficient Transferrin as Biomarkers of Alcohol Consumption

Comparison of the Diagnostic Value of Phosphatidylethanol and Carbohydrate‐Deficient Transferrin as Biomarkers of Alcohol Consumption

Daily use of alcohol in the Norwegian general population: Prevalence and associated factors

Prevalence of psychoactive substance use among acutely hospitalised patients in Oslo and Moscow: a cross-sectional, observational study

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