‘Hardy’s Law’ and genomics in Anaesthesia

Cytochrome P450 3A4 genetic polymorphisms and post-operative fentanyl requirements

“… 8 at 4·3% in the same local population. Hardy–Weinberg equilibrium confirms that our patient selection was sufficiently random and representative of the wider population 18 . To date, there is still no local data available for comparison of the CYP3A4 genotypes, among the different races in Malaysia.…”

“…Hardy-Weinberg equilibrium confirms that our patient selection was sufficiently random and representative of the wider population. 18 To date, there is still no local data available for comparison of the CYP3A4 genotypes, among the different races in Malaysia. The frequencies of various CYP3A4 variant alleles reported in various studies among Asian populations are given in Table 3.…”

The analysis of variance in anaesthetic research: statistics, biography and history

“…[17] In 1912, Fisher obtained a First in the mathematics tripos, but missed a 'Wrangler' rank because G.H. Hardy (of the Hardy-Weinberg principle) had abolished such rankings when he was examiner [18,19]. Nonetheless, Fisher acknowledged that Hardy had taught him 'all that I know of pure mathematics' [20].…”

When rain stops play: a ‘Duckworth–Lewis method’ for surgical operating list productivity?

“…The eccentric Cambridge mathematician GH Hardy (who has been discussed previously in the pages of this journal ), often used cricketing analogies to explain mathematical ideas. The Hardy–Littlewood maximal function is a complex operator used in harmonic analysis.…”