The RISC-V open Instruction Set Architecture (ISA) has proven to be a solid alternative to licensed ISAs. In the past 5 years, a plethora of industrial and academic cores and accelerators have been developed implementing this open ISA.In this paper, we present Sargantana, a 64-bit processor based on RISC-V that implements the RV64G ISA, a subset of the vector instructions extension (RVV 0.7.1), and custom applicationspecific instructions. Sargantana features a highly optimized 7-stage pipeline implementing out-of-order write-back, register renaming, and a non-blocking memory pipeline. Moreover, Sargantana features a Single Instruction Multiple Data (SIMD) unit that accelerates domain-specific applications. Sargantana achieves a 1.26 GHz frequency in the typical corner, and up to 1.69 GHz in the fast corner using 22nm FD-SOI commercial technology.As a result, Sargantana delivers a 1.77× higher Instructions Per Cycle (IPC) than our previous 5-stage in-order DVINO core, reaching 2.44 CoreMark/MHz. Our core design delivers comparable or even higher performance than other state-ofthe-art academic cores performance under Autobench EEMBC benchmark suite. This way, Sargantana lays the foundations for future RISC-V based core designs able to meet industrialclass performance requirements for scientific, real-time, and highperformance computing applications.