Harderian Gland Development and Degeneration in the Fgf10-Deficient Heterozygous Mouse
Shiori Ikeda,
Keita Sato,
Hirofumi Fujita
et al.
Abstract:The mouse Harderian gland (HG) is a secretory gland that covers the posterior portion of the eyeball, opening at the base of the nictitating membrane. The HG serves to protect the eye surface from infection with its secretions. Mice open their eyelids at about 2 weeks of age, and the development of the HG primordium mechanically opens the eye by pushing the eyeball from its rear. Therefore, when HG formation is disturbed, the eye exhibits enophthalmos (the slit-eye phenotype), and a line of Fgf10+/− heterozygo… Show more
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