Haptoglobin Types in Natives from the Kuru Region and other Parts of Melanesia

Bennett, J. H.

doi:10.1136/bmj.2.5249.428

Cited by 5 publications

(4 citation statements)

References 2 publications

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“…In many diseases the distribution of haptoglobin types and/or blood groups has been found to accord with those in normal individ uals [2,5,7,8,10,23], and Ikkala [14] confirmed the normality of blood group distribution in haemophilics. In the present investigation no statistically significant difference was found between the hapto globin phenotypes of haemophilics and of normal individuals.…”

Section: Discussionmentioning

confidence: 83%

“…Type 0-0 individuals are those who show no haemoglobin-binding protein, but show free haemoglo bin in the starch-gel. Because of the belief that there are two controlling allelic genes for each haptoglobin type and in order to compare the results statis tically with previously reported studies [7,18], individuals with ahaptoglobinaemia (type 0-0) were excluded in calculating the gene frequencies. Expected values for various haptoglobin phenotypes have therefore been calculated on the basis of the Hardy-Weinberg equation (type 1-1 = p2, type 2-1 = 2pq and type 2-2 = q2 where p = Hp1 gene frequency and q = Hp2 gene frequency).…”

Section: Methodsmentioning

confidence: 99%

“…No clear cut relationship has yet been found between haptoglobin types, transferrin types and speci fic clinical disorders; perhaps, however, as Allison [1] points out, due to the relatively small number of individuals so far tested it would only have shown up had the correlation been high. Reports on such associations have been controversial [7,8,18,27] and it has been re commended that work on this matter should be extended [13].…”

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confidence: 99%

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A Comparison of Haptoglobin Phenotypes in Haemophilics and Normals in Scotland

Kamel¹,

Davies²,

Cumming³

1963

Vox Sanguinis

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Section: Discussionmentioning

confidence: 83%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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A Comparison of Haptoglobin Phenotypes in Haemophilics and Normals in Scotland

Kamel¹,

Davies²,

Cumming³

1963

Vox Sanguinis

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“…No clear cut relationship has yet bern found between haptoglobin types, transfcrrin typcs and specific clinical disordcrs; pcrhaps, however, as Allison [1] poinLs out, due to the relativcly small number of individuals so far trsted it would only have shown up had the correlation been high. Reports on such associations have been controversial [7,8,18,271 and it has bern recommrnded that work on this matter should be cxtrndcd [13].…”

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confidence: 99%

A Comparison of Haptoglobin Phenotypes in Haemophilics and Normals in Scotland

1963

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Scotlarid I3lood Transfusion S e n ire, The Royal Infirmary of Edinburgh When normal plasma is subjcctcd t o electrophoretic analysis in free solution or in a supporting medium such as filter paper or cellulose acetate, six components can usually be identified; these arc albumin, the alpha l, alpha 2, beta ant1 gamma globulins and fibrinogen.Quantitative variations in such componmts have been related l o various disease states. When, howcver, normal plasma or serum was run electrophoretically on starch-gel by Smithips in 1955 [24] he ob-

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Haptoglobins and transferrins in Melanesia: Relation to hemoglobin, serum haptoglobin and serum iron levels in population groups in Papua—New Guinea

Curtain¹,

Gajdusek²,

Kidson³

et al. 1965

American J Phys Anthropol

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This paper reports haptoglobin and transferrin typing of 2687 serum specimens from Melanesians of New Guinea and New Britain. The specimens were obtained from members of 27 different cultural and linguistic groups residing in over 100 different villages in six different administrative districts. They were divided among the Districts as follows: New Britain 821, Sepik 623, Morobe 349, Eastern Highlands 613, Southern Highlands 222, and Western Highlands 59.In addition serum haptoglobin levels, serum iron levels and total serum iron binding capacity have been determined on these subjects. In the field hemoglobin determinations, blood smears for examination for malaria parasite rates, and spleen palpations were done on a proportion of the subjects, mostly children under ten years whose sera have been examined in this study. These field and laboratory results are correlated with the transferrin and haptoglobin gene frequency findings.The available data on haptoglobin and transferrin types in Melanesia is limited almost entirely to small groups in certain areas of the highlands of New Guinea. taken from the same specimens whose clots were examined for bIood group studies which have been recently reported. Thus, detailed discussions of many of the populations under investigation, their linguistic and cultural affiliations, and their ethnic origins have been presented along with brief discussions of the medical problems in each area in a series of recent reports

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Haptoglobin Types in Natives from the Kuru Region and other Parts of Melanesia

Cited by 5 publications

References 2 publications

A Comparison of Haptoglobin Phenotypes in Haemophilics and Normals in Scotland

A Comparison of Haptoglobin Phenotypes in Haemophilics and Normals in Scotland

A Comparison of Haptoglobin Phenotypes in Haemophilics and Normals in Scotland

Haptoglobins and transferrins in Melanesia: Relation to hemoglobin, serum haptoglobin and serum iron levels in population groups in Papua—New Guinea

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