Haptoglobin Subtypes in a Schizophrenic and Control Population

Haptoglobin and Transferrin Types in Schizophrenia

“…The study by Lovegrove and Nicholls [ 1965] showed a signifi cant excess of Hp 2-1 heterozygotes in both patients and controls, a fact that was not mentioned by the authors. There were 58% heterozygotes among the patients and 60% among the controls which suggests some kind of classification problem.…”

“…In later studies no association between Hp types and schizophrenia was found [Lovegrove and Nicholls, 1965;Brackenridge and Jones. 1972; 1 This work was supported by grants from the Erik Philip-Sorensen and Nilsson-Ehle Foundations.…”

The Association of Hp 1 and Sickle Cell Disease

“…Associations between Hp type and dis eases such as phenylketonuria [Hsia et al, 1969], chronic leukemia [Latner and Zaki, 1969], Alzheimer's disease and senile de mentia [Op de Velde and Stam, 1973], de pression spectrum disease [Tanna et al, 1979] , retinal detachment [Padma et al, 1980] and schizophrenia [Rudduck et al, 1985] have been reported. No correlation between Hp type and disease was reported in other studies of anomalies such as schi zophrenia [Lovegrove and Nicholls, 1965], cardiac infarction, psoriasis, colon cancer, cholelithiasis, gastric ulcers and neurodermitis [Ihm and Wendt, 1966], diabetes mellitus, acute and chronic hepatitis, liver cirrhosis, psoriasis vulgaris [Jorgensen and Hopper, 1967], pulmonary tuberculo sis [Jorgensen and Rubberdt, 1968], Down's syndrome [Ball et al, 1972], can cer [Baksi et al, 1976], manic depressive disorder [Johnson et al, 1981], multiple myeloma [Germenis et al, 1983] and de mentia of Alzheimer type and multi-in farct dementia [Frohlander and Adolfson, 1985], This report presents the results of an investigation of Hp types in 320 Black individuals screened for hemoglobino pathies. …”

Schizophrenia or Antiphrenia?

“…Nazarov (1962) demonstrated that schizophrenics had increased skin sensitivity to brain proteins. Other workers have not been able to demonstrate abnormalities in serum proteins (Lovegrove and Nicholls, 1965;Bishop et a/., 1956;Solomon et a/., 1969;Bock et a/., 1971) or in the effect of schizophrenics' serum on evoked cortical potentials (German, 1963;Stenhouse et a/., 1965;German ef a/., 1965). Five markers of autoimmune disorders have been postulated by Mackay and Burnet (1963).…”