Haptoglobin polymorphism, plasma haptoglobin level and ABO blood group in leprosy patients

Seboka, Nigussie; Bekele, Endashaw; Nigussie, Shimelis; Bekele, Yonas; Bobosha, Kidist; Beyene, Demissew

doi:10.12980/jclm.5.2017j7-151

Cited by 16 publications

(3 citation statements)

References 28 publications

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“…IgM, IgA, and IgG have all been linked to both the reversal reaction and erythema nodosum leprosum reactions in patients with MB leprosy 47 , 48 , 50 , 71 ; however, without determining the antigen specificity of the recovered immunoglobulins, which is beyond the scope of this study, we are unable to utilize them diagnostically. Other proteins associated with an increased expression during leprosy infections and immune responses are haptoglobin 51 , 75 ; C-reactive protein, 41 , 48 and Apolipoprotein A-1. 48 We found that extracts from two individuals (ZH1114, ZH1117) buried within the leprosarium demonstrated the strongest identified immune response suggestive of active leprosy.…”

Section: Discussionmentioning

confidence: 99%

Sequential trypsin and ProAlanase digestions unearth immunological protein biomarkers shrouded by skeletal collagen

Wilkin,

Lanigan,

Montes

et al. 2024

iScience

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Section: Discussionmentioning

confidence: 99%

Sequential trypsin and ProAlanase digestions unearth immunological protein biomarkers shrouded by skeletal collagen

Wilkin,

Lanigan,

Montes

et al. 2024

iScience

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“…Gupta et al [11] reported differential expression of Hp and its isoforms in serum of leprosy cases experiencing ENL reaction as compared to healthy controls. Seboka et al [37] revealed that Hp polymorphism and blood groups does not affect leprosy whereas, plasma Hp elevates in leprosy cases and is associated with bacterial loads and leprosy spectrum. Here, based on bioinformatic analysis we found Hp isoform 1 to be overexpressed in the serum of contacts and leprosy cases as compared to healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Identification of alpha 1B glycoprotein and haptoglobin 1 as probable biomarkers for early diagnosis of leprosy

Gautam

Sharma

Singh

et al. 2023

Preprint

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Diagnosis of early leprosy is a major hurdle to disease control and has been compromised due to lack of specific markers or tests. As proteins are the functional moiety, circulating proteins in sera could be attractive diagnostic markers of disease. Our knowledge regarding the proteome of contacts, which contribute the highest risk group for leprosy development, is not comprehensive. Development of highly sensitive diagnostic methods to screen this population is need of the hour. Present study exploited the proteomics tools for differential expression of novel proteins in sera of contact and leprosy case as compared to healthy control. Highly abundant proteins were removed from the serum sample, followed by two-dimensional gel electrophoresis and liquid chromatography-mass spectrometry, bioinformatics tools for protein identification. On analyzing and comparing the two-dimensional patterns, we observed differential expression of five proteins, four proteins were over-expressed, and one protein was downregulated. Four over-expressed proteins were identified as alpha 1B glycoprotein (A1BG), haptoglobin 1, serotransferrin isoforms 1 and 3 and one under expressed protein was identified as hemopexin. We propose identification of two potential candidate biomarkers alpha 1B glycoprotein and haptoglobin 1 for diagnosis of early leprosy. These proteins might serve as potential biomarkers for diagnosis of early leprosy and would allow interventions before the onset of clinical symptoms.

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“…These new paradigms shift to inclusive education of the country show a need to investigate about implementation of inclusive education in terms of its practices, opportunities and challenges in current school settings. In this regard, [9] stated that the current movements of inclusion of pupils with special educational needs in mainstream schools should be assessed in terms of its potential impact on pupils' academic performance as well as its impact on their social adaptation. This requires an in-depth study in implementation of polices in the education system of inclusive primary schools.…”

Section: Statement Of the Problemmentioning

confidence: 99%

Practices, Challenges and Opportunities of Inclusive Education Implementation in Kambata Tambaro Zone, Ethiopia

Ludago¹

2020

OALib

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The purpose of this study was to assess the practices, challenges and opportunities of implementation of inclusive education in Kembara Tembaro zone, Southern Ethiopia. The study used qualitative research method to collect data. This method is concerned with exploring the existing current status of inclusive education practices, challenge and opportunities. Participants of the study were seven district education experts, seven school principals, two education experts of the zone and two education experts of the region bureau included in the study. For data collection interview, document consultation and checklists were used. The finding revealed that there are inadequate infrastructures and education facilities, sanitation facilities, lack of ramps, dirty and dusty classrooms and acoustically non-treated classrooms, equipments and services; moreover, negative attitudes of teachers, lack of budget, limited professionals, lack of responsible personnel in district, zone and region education offices. Parents started to send their children to school; however, there is lack of skilled professionals who will screen and identify according to interests of learners. There is highest number of repeaters and dropouts in early schools because of unfriendly learning environment for diversified learners. The study suggested that high attention is needed from the concerned parties for the implementation of the inclusive education in the zone.

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Haptoglobin polymorphism, plasma haptoglobin level and ABO blood group in leprosy patients

Cited by 16 publications

References 28 publications

Sequential trypsin and ProAlanase digestions unearth immunological protein biomarkers shrouded by skeletal collagen

Sequential trypsin and ProAlanase digestions unearth immunological protein biomarkers shrouded by skeletal collagen

Identification of alpha 1B glycoprotein and haptoglobin 1 as probable biomarkers for early diagnosis of leprosy

Practices, Challenges and Opportunities of Inclusive Education Implementation in Kambata Tambaro Zone, Ethiopia

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