Haptoglobin polymorphism and prostate cancer mortality

Kaiser, Melanie; Thurner, E.M.; Mangge, Harald; Herrmann, Markus; Semeraro, Maria Donatella; Renner, Wilfried; Langsenlehner, Tanja

doi:10.1038/s41598-020-69333-z

Cited by 8 publications

(5 citation statements)

References 33 publications

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“…Hemoglobin is a protein in red blood cells responsible for carrying oxygen from the lungs to various parts of the body and transporting carbon dioxide back to the lungs for exhalation[ 18 ]. Hemoglobin content is an important indicator of the body's oxygen transport capacity[ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Anemia status of infants and young children aged six to thirty-six months in Ma'anshan City: A retrospective study

Wang,

Huang

2023

World J Clin Cases

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β cells are the main cells responsible for the hypoglycemic function of pancreatic islets, and the insulin secreted by these cells is the only hormone that lowers blood glucose levels in the human body. β cells are regulated by various factors, among which neurotransmitters make an important contribution. This paper discusses the effects of neurotransmitters secreted by various sympathetic and parasympathetic nerves on β cells and summarizes the mechanisms by which various neurotransmitters regulate insulin secretion. Many neurotransmitters do not have a single source and are not only released from nerve terminals but also synthesized by β cells themselves, allowing them to synergistically regulate insulin secretion. Almost all of these neurotransmitters depend on the presence of glucose to function, and their actions are mostly related to the Ca2+ and cAMP concentrations. Although neurotransmitters have been extensively studied, many of their mechanisms remain unclear and require further exploration by researchers.

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Section: Discussionmentioning

confidence: 99%

Anemia status of infants and young children aged six to thirty-six months in Ma'anshan City: A retrospective study

Wang,

Huang

2023

World J Clin Cases

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“…Thus, the lower levels of serum haptoglobin in thalassemic patients could be attributed to presence of different polymorphisms of the haptoglobin gene. Kaiser et al [7] found that people with Hp2-2 have the lowest concentrations of Hp, while those with Hp1-1 have the highest, and the ones with Hp2-1 have concentrations fall somewhere in between.…”

Section: Ragab Et Al [19]mentioning

confidence: 99%

Impact of Haptoglobin Gene Polymorphism on Phenotypic Variability in β-thalassemia Patients: Relation to Iron Overload and Oxidative Stress

Balbaa,

Kamel,

Salem

et al. 2023

Afro-Egyptian Journal of Infectious and Endemic Diseases

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Backgroundand study aim: Thalassemia syndromes are genetic disorders in globin chain production. There is excessive synthesis of reactive oxygen species in thalassemia which leads to oxidative stress. Excessive production of malondialdehyde (MDA) provides evidence that thalassemic erythrocytes contain a significant amount of membrane-bound iron. Inflammatory cytokines trigger the production of haptoglobin (Hp) in the liver. It is characterized by molecular heterogeneity brought on by genetic polymorphism. The aim of the work was to study the impact of haptoglobin gene polymorphism on phenotypic variability in thalassemia patients and its relation to iron overload and oxidative stress. Patients and Methods: This study was carried out on 50 β-thalassemia major patients in addition to 25 healthy age and sex-matched individuals as control. All patients and control were subjected to: history taking, physical examination, Laboratory investigations, Iron profile, Serum ferritin, Serum haptoglobin (Hp), Serum malondialdehyde (MDA), and Haptoglobin gene polymorphism by (PCR). Results:The study revealed significant decrease in serum haptoglobin and significant increase in MDA and ferritin level in thalassemic patients compared to the control group. Higher incidence of Hp2-2 in thalassemic group while control group showed more prevalence of Hp2-1. Serum level of MDA was significantly higher and haptoglobin levels were significantly lower in patients with Hp2-2 genotype. Serum ferritin was higher in the same genotype but did not reach significant value. Conclusion:Haptoglobin polymorphism and phenotypic variability have a major influence on oxidative stress in thalassemia patients.

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“…Numerous studies indicate that an individual’s belonging to the Hp polymeric phenotype (Hp2-1 and, especially, Hp2-2) is associated with the risk of many common diseases: cardiovascular, autoimmune, infectious, atherosclerosis, stroke, diabetes, tuberculosis, epilepsy, diabetic nephropathy, diabetic retinopathy, malignant neoplasms, weakening of cognitive functions [ 33 – 36 , 51 – 53 ]. However, in the case of prostate cancer, the role of the phenotype has not been found [ 54 ]. An important site of Hp synthesis, apart from the liver, is the lungs.…”

Section: Basic Functions and Role Of The Hp Phenotypementioning

confidence: 99%

Haptoglobin as a Biomarker

Naryzny

Legina

2021

Biochem. Moscow Suppl. Ser. B

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— Haptoglobin (Hp) is a glycoprotein that binds free hemoglobin (Hb) in plasma and plays a critical role in tissue protection and prevention of oxidative damage. Besides, it has some regulatory functions. Haptoglobin is an acute-phase protein, its concentration in plasma changes in pathology, and the test for its concentration is part of normal clinical practice. Haptoglobin is a conservative protein synthesized mainly in the liver and lungs and is the subject of research as a potential biomarker of many diseases, including various forms of malignant neoplasms. Haptoglobin has several unique biophysical characteristics. The human Нр gene is polymorphic, has three structural alleles that control the synthesis of three major phenotypes of haptoglobin: homozygous Нр1-1 and Нр2-2, and heterozygous Нр2-1, determined by a combination of allelic variants that are inherited. Numerous studies indicate that the phenotype of haptoglobin can be used to judge the individual predisposition of a person to various diseases. In addition, Hp undergoes various post-translational modifications (PTMs). These are structural transformations (removal of the signal peptide, cutting off the Pre-Hp precursor molecule into two subunits, α and β, limited proteolysis of α-chains, formation of disulfide bonds, multimerization), as well as chemical modifications of α-chains and glycosylation of the β-chain. Glycosylation of the β-chain of haptoglobin at four Asn sites is the most important variable PTM that regulates the structure and function of the glycoprotein. The study of modified oligosaccharides of the β-chain of Hp has become the main direction in the study of pathological processes, including malignant neoplasms. These characteristics indicate the possibility of the existence of Hp in the form of a multitude of proteoforms, probably performing different functions. This review is devoted to the description of the structural and functional diversity and the potential use of Hp as a biomarker of various pathologies.

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Haptoglobin polymorphism and prostate cancer mortality

Cited by 8 publications

References 33 publications

Anemia status of infants and young children aged six to thirty-six months in Ma'anshan City: A retrospective study

Anemia status of infants and young children aged six to thirty-six months in Ma'anshan City: A retrospective study

Impact of Haptoglobin Gene Polymorphism on Phenotypic Variability in β-thalassemia Patients: Relation to Iron Overload and Oxidative Stress

Haptoglobin as a Biomarker

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