Haptoglobin Polymorphism And Mortality In Patients With Tuberculosis

Kasvosve, Ishmael; Gomo, Zvenyika A. R.; Mvundura, Elisha; Moyo, Victor; Saungweme, Thokozile; Khumalo, Hlosukwazi; Boelaert, Johan R.; Delanghe, J.; Bacquer, Dirk De; Gangaidzo, Innocent T.

doi:10.1007/978-3-642-18480-2_7

Cited by 27 publications

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“…Clinical studies investigating the link between Hp polymorphisms and tuberculosis failed to prove increased susceptibility in a particular Hp phenotype, but patients with the 2-2 phenotype had a higher risk for advanced and therapyresistant disease [27]. The incidence of nephrotic tuberculosis [28] was also higher, as was the frequency of recurrent tuberculosis [29].…”

Section: Discussionmentioning

confidence: 99%

Haptoglobin Polymorphisms Are Associated with Crohn’s Disease, Disease Behavior, and Extraintestinal Manifestations in Hungarian Patients

et al. 2007

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Functional differences and association with inflammatory disorders were found relating to three major haptoglobin (Hp) phenotypes. Our aim was to investigate Hp polymorphisms in Hungarian patients with Crohn's disease (CD). Four hundred sixty-eight CD patients and 384 healthy controls were examined. Hp phenotypes were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting of the sera. The frequency of the Hp(1) allele was significantly higher in CD (0.395; OR, 1.24; 95% CI, 1.02-1.52; P=0.03) compared to controls (0.345). In CD, Hp phenotype was associated with disease behavior (OR [Hp(2-1) vs other], 2.06; 95% CI, 1.29-3.28 for inflammatory behavior). Furthermore, an increased frequency of primary sclerosing cholangitis was observed in the Hp 2-2 compared to the Hp 1-1 phenotype (6.5% vs. 0.0%; P=0.039). We conclude that the Hp polymorphism is associated with CD, inflammatory disease behavior, and primary sclerosing cholangitis in Hungarian patients. Further studies are required to evaluate the significance of Hp polymorphisms in other populations from geographically diverse regions.

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Section: Discussionmentioning

confidence: 99%

Haptoglobin Polymorphisms Are Associated with Crohn’s Disease, Disease Behavior, and Extraintestinal Manifestations in Hungarian Patients

et al. 2007

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“…Moreover, the Hb-Hp2.2 complex, but not other Hp1 complexes, can be internalized by monocytes and stimulate the release of proinflammatory cytokines (57). Indeed, the Hp2.2 phenotype has been associated with susceptibility to several inflammatory conditions, including malaria (11,20,22,28,36,55,58). Haptoglobin is considered an acute-phase protein that increases 2-to 4-fold during the response to acute inflammation (35).…”

Section: Discussionmentioning

confidence: 99%

Association between the Haptoglobin and Heme Oxygenase 1 Genetic Profiles and Soluble CD163 in Susceptibility to and Severity of Human Malaria

et al. 2012

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ABSTRACTIntravascular hemolysis is a hallmark event in the immunopathology of malaria that results in increased systemic concentrations of free hemoglobin (Hb). The oxidation of Hb by free radicals causes the release of heme, which amplifies inflammation. To circumvent the detrimental effects of free heme, hosts have developed several homeostatic mechanisms, including the enzyme haptoglobin (Hp), which scavenges cell-free Hb, the monocyte receptor CD163, which binds to Hb-Hp complexes, and heme oxygenase-1 (HO-1), which degrades intracellular free heme. We tested the association between these three main components of the host response to hemolysis and susceptibility to malaria in a Brazilian population. The genetic profiles of theHMOX1andHpgenes and the plasma levels of a serum inflammatory marker, the soluble form of the CD163 receptor (sCD163), were studied in 264 subjects, including 78 individuals with symptomatic malaria, 106 individuals with asymptomatic malaria, and 80 uninfected individuals. We found that long (GT)nrepeats in the microsatellite polymorphism region of theHMOX1gene, theHp2allele, and theHp2.2genotype were associated with symptomatic malaria. Moreover, increased plasma concentrations of heme, Hp, HO-1, and sCD163 were associated with susceptibility to malaria. The validation of these results could support the development of targeted therapies and aid in reducing the severity of malaria.

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“…Eaton et al (1982) reported that the simultaneous administration of Hp in rats inoculated intraperitoneally with pathogenic Escherichia coli and Hb protected the animals against death. Kasvosve et al (2000) showed that in a logistic regression model the odds of patients with tuberculosis dying were 6.1 times greater in individuals with the Hp 2-2 phenotype than in those with the Hp 1-1 phenotype. Furthermore, the Hp2-2 phenotype was overrepresented among patients with large cavities created by tissue destruction, more advanced dissemination and the presence of nephrotic tuberculosis (Fedoseeva et al, 1993;Ubaidullaev et al, 2002).…”

Section: Infectious Diseasesmentioning

confidence: 99%

Polymorphism of human haptoglobin and its clinical importance

2008

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Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders.

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Haptoglobin Polymorphism And Mortality In Patients With Tuberculosis

Cited by 27 publications

References 0 publications

Haptoglobin Polymorphisms Are Associated with Crohn’s Disease, Disease Behavior, and Extraintestinal Manifestations in Hungarian Patients

Haptoglobin Polymorphisms Are Associated with Crohn’s Disease, Disease Behavior, and Extraintestinal Manifestations in Hungarian Patients

Association between the Haptoglobin and Heme Oxygenase 1 Genetic Profiles and Soluble CD163 in Susceptibility to and Severity of Human Malaria

Polymorphism of human haptoglobin and its clinical importance

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