Haptoglobin phenotypes and plasma haptoglobin levels in patients with abdominal aortic aneurysm

Pan, Ju Pin; Cheng, Tsai Mu; Shih, Chun Che; Chiang, Shu Chiung; Chou, Shiu Chin; Mao, Simon J.T.; Lai, Shiau Ting

doi:10.1016/j.jvs.2010.10.122

Cited by 17 publications

(28 citation statements)

References 32 publications

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“…This may be because the purification process involved in the Hp immunoassay is challenging [17,18]. Of note, we have previously reported that plasma Hp concentrations are elevated in patients with abdominal aortic aneurysm (perhaps due to inflammation in the destructive elastic laminae of arteries) [19]. The aim of this study was to investigate plasma Hp concentrations and Hp phenotype in a cohort of Chinese patients with coronary artery disease (CAD).…”

Section: Introductionmentioning

confidence: 99%

Plasma Haptoglobin Concentrations Are Elevated in Patients with Coronary Artery Disease

et al. 2013

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Inflammation underlies the development and progression of coronary artery plaques. Haptoglobin (Hp) is an acute phase protein, the synthesis of which is increased during inflammation. The aim of this study was to investigate plasma Hp concentrations and phenotype in patients with coronary artery disease (CAD). We recruited 359 patients with fixed luminal stenosis ≥50% in at least one coronary artery (CAD group) and 83 patients with luminal stenosis ≤40%, normal ejection fraction, and normal regional wall motion (control group). Plasma Hp concentrations were measured using a phenotype-specific enzyme-linked immunosorbent assay. Hp phenotype was determined by native polyacrylamide gel electrophoresis. Plasma lipid concentrations were measured. Plasma Hp concentrations were significantly higher in the CAD compared with the control group (262.4±144.2 vs 176.0±86.7 ng/mL, P<0.001); however, there was no between group difference in the distribution of Hp phenotype (1-1 = 7.5% vs 7.2%; 2-1 = 40.4% vs 42.2%; 2-2 = 52.1% vs 50.6%). Stepwise multivariate logistic regression revealed that high Hp concentrations (odds ratio [OR] = 5.865), male sex (OR = 3.689), hypertension (OR = 2.632), diabetes mellitus (OR = 3.300), and low-density lipoprotein concentrations (OR = 1.480) were independently associated with CAD (all P<0.05). Hp phenotype was not associated with CAD. Plasma Hp concentrations were significantly correlated with the severity of luminal stenosis (r = 0.236, P<0.001). Our findings suggest that plasma Hp concentrations may be elevated in patients with CAD. There does not appear to be any relationship between Hp phenotype and CAD.

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Section: Introductionmentioning

confidence: 99%

Plasma Haptoglobin Concentrations Are Elevated in Patients with Coronary Artery Disease

et al. 2013

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“…For the remaining 18 patients, the mean haptoglobin on day 0 was 274 ± 142 mg/dl (median 283, range 59-551). There was no correlation between patient age and baseline haptoglobin levels (data not shown, R=0.004) [15].…”

Section: Patientsmentioning

confidence: 87%

“…The normal range during the study period was 22-239 mg/dl. Haptoglobin phenotyping (Hp1, Hp2) was not performed [2,15].…”

Section: Haptoglobin Measurementmentioning

confidence: 99%

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Inferior Vena Cava Filters as a Potential Non-immune Cause of Low Serum Haptoglobin

Cooling¹,

Giacherio²,

Elkins³

2017

J Blood Disord Transfus

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Objective: Serum haptoglobin level is commonly used as a marker of hemolysis. We hypothesized that inferior vena cava (IVC) filters may be a potential non-immune etiology for subclinical hemolysis and low haptoglobin in some patients, after encountering a patient with an IVC filter, mild macrocytic anemia and unexplained severe haptoglobinemia. IVC filters can be associated with pressure gradients and turbulent blood flow in the presence of trapped clots and thrombus formation. Methods:Prospective study in patients undergoing IVC filter placement at our institution over a 3-month period in 2008. All patients had a haptoglobin level prior to filter placement, and then daily for a period of 3-14 days. The absolute and relative change in haptoglobin compared to pre-procedure levels was determined. Results were evaluated by t-test (paired, 2-tail). Statistics and graphics were performed with commercial software.Results: A total of 22 patients underwent IVC filter placement. Four patients were excluded due to low preprocedure haptoglobin levels. At least one post-procedure haptoglobin values was available until day 3 in 18/18 eligible patients. Nine patients were followed for a period of 1-2 weeks. Although the majority of patients had an increase in haptoglobin after IVC filter placement, 3/9 (30%) had >50% decrease in haptoglobin by day 7, including one patient with severe haptoglobinemia by day 14. Patients with decreased haptoglobin levels also had decreases in platelet count over the same period. Conclusion:These results suggest that IVC filters may be another non-immune, device-related cause of decreased haptoglobin in some patients.

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“…In particular, Pan et al [38] demonstrated that plasma Hp concentration was elevated in patients with AAA, particularly those with the Hp 2-2 phenotype. They suggested that if the results of this study were confirmed and extended by a further larger scale study, Hp concentration among with Hp2-2 phenotype might be potential biomarkers of AAA development and could be used clinically in association with other biomarkers [38]. Concerning proteins belonging to lipid metabolic process, we found apolipoproteins.…”

Section: Go:0006955 Immune Responsementioning

confidence: 99%

Using Proteomics to Understand Abdominal Aortic Aneurysms: Where Are We?

Gamberi¹,

Aless²,

Modesti³

et al. 2016

J Proteomics Bioinform

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Haptoglobin phenotypes and plasma haptoglobin levels in patients with abdominal aortic aneurysm

Abstract: Our findings suggest that plasma Hp concentrations are elevated in patients with AAA, particularly those with the Hp 2-2 phenotype.

Cited by 17 publications

References 32 publications

Plasma Haptoglobin Concentrations Are Elevated in Patients with Coronary Artery Disease

Plasma Haptoglobin Concentrations Are Elevated in Patients with Coronary Artery Disease

Inferior Vena Cava Filters as a Potential Non-immune Cause of Low Serum Haptoglobin

Using Proteomics to Understand Abdominal Aortic Aneurysms: Where Are We?

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