Haptoglobin phenotype influences the effectiveness of diet-induced weight loss in middle-age abdominally obese women with metabolic abnormalities

Tang, Kelvin Yohanes; Huang, Shih‐Yi; Cheng, Tsai Mu; Bai, Chyi Huey; Chang, Jung Su

doi:10.1016/j.clnu.2019.01.019

Cited by 12 publications

(6 citation statements)

References 39 publications

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“…In a study of 151 obese women undergoing weight loss dietary intervention, the genotype of the apolipoprotein A5 (APOA5) gene, which is associated with obesity and cardiovascular metabolic risk, influenced the effectiveness of the dietary intervention. This finding provides a new research direction for personalized dietary interventions ( 24 ).…”

Section: Hfd Promotes the Development Of Metabolic Diseasesmentioning

confidence: 76%

Exploring a novel therapeutic strategy: the interplay between gut microbiota and high-fat diet in the pathogenesis of metabolic disorders

Jia,

Chen,

et al. 2023

Front. Nutr.

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In the past two decades, the rapid increase in the incidence of metabolic diseases, including obesity, diabetes, dyslipidemia, non-alcoholic fatty liver disease, hypertension, and hyperuricemia, has been attributed to high-fat diets (HFD) and decreased physical activity levels. Although the phenotypes and pathologies of these metabolic diseases vary, patients with these diseases exhibit disease-specific alterations in the composition and function of their gut microbiota. Studies in germ-free mice have shown that both HFD and gut microbiota can promote the development of metabolic diseases, and HFD can disrupt the balance of gut microbiota. Therefore, investigating the interaction between gut microbiota and HFD in the pathogenesis of metabolic diseases is crucial for identifying novel therapeutic strategies for these diseases. This review takes HFD as the starting point, providing a detailed analysis of the pivotal role of HFD in the development of metabolic disorders. It comprehensively elucidates the impact of HFD on the balance of intestinal microbiota, analyzes the mechanisms underlying gut microbiota dysbiosis leading to metabolic disruptions, and explores the associated genetic factors. Finally, the potential of targeting the gut microbiota as a means to address metabolic disturbances induced by HFD is discussed. In summary, this review offers theoretical support and proposes new research avenues for investigating the role of nutrition-related factors in the pathogenesis of metabolic disorders in the organism.

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Section: Hfd Promotes the Development Of Metabolic Diseasesmentioning

confidence: 76%

Exploring a novel therapeutic strategy: the interplay between gut microbiota and high-fat diet in the pathogenesis of metabolic disorders

Jia,

Chen,

et al. 2023

Front. Nutr.

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“…In the current study, we observed that a significant difference in mean weight between study groups was maintained for the duration of the study for the non-Hp2-2 phenotype group only. In a recent study investigating the relationship between Hp phenotype and diet-induced weight loss, the Hp1-1 phenotype was associated with greater improvements in abdominal obesity, plasma insulin levels, and insulin resistance when compared to the Hp2-1 and Hp2-2 phenotypes in women with obesity; however, weight/BMI change was not different between phenotypes [ 36 ]. Similarly, in another study intermittent fasting was associated with a greater reduction in waist circumference among overweight/obese people with the Hp1-1 phenotype when compared to people with the Hp2-1 and Hp2-2 phenotypes [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Intensive lifestyle intervention in type 2 diabetes and risk of incident coronary artery disease for the common haptoglobin phenotypes: the Look AHEAD study

Warren,

Bancks,

Carew

et al. 2024

Cardiovasc Diabetol

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Background Intensive glycemic control reduced coronary artery disease (CAD) events among the Action to Control Cardiovascular Disease Risk in Diabetes (ACCORD) participants with the haptoglobin (Hp) 2-2 phenotype only. It remains unknown whether Hp phenotype modifies the effect of an intensive lifestyle intervention (ILI) on CAD in type 2 diabetes. Methods Haptoglobin phenotype was measured in 4542 samples from the Action for Health in Diabetes (Look AHEAD) study. Cox regression models assessed the effect of ILI (focused on weight loss from caloric restriction and physical activity) versus diabetes support and education (DSE) on CAD events in each phenotype group, and within pre-specified subgroups including race/ethnicity, sex, history of cardiovascular disease, diabetes medication use, and diabetes duration. Results 1590 (35%) participants had the Hp2-2 phenotype. The ILI did not lower glycated hemoglobin (%HbA1c) to < 6.5% in either phenotype, with a peak significant difference between treatment arms of 0.5% [non-Hp2-2] and 0.6% [Hp2-2]. The cumulative CAD incidence was 13.4% and 13.8% in the DSE arm and 12.2% and 13.6% in the ILI arm for non-Hp2-2 and Hp2-2 groups, respectively. Compared to DSE, the ILI was not associated with CAD among participants without (HR = 0.95, 95% CI 0.78–1.17) or with (0.89, 0.68–1.19) the Hp2-2 phenotype (p-interaction between Hp phenotype and ILI = 0.58). After Bonferroni correction, there were no significant results among any subgroups. Conclusions Hp phenotype did not modify the effect of the weight loss ILI on risk of CAD in Look AHEAD, potentially because it did not substantially impact glycemic control among participants with or without the Hp2-2 phenotype. Further research is needed to determine if these results are conclusive.

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“…25 Among these variants, Hp 2-2 was shown to be less protective against oxidative stress and was associated with a variety of cardiovascular diseases. [26][27][28] Moreover, in one study, it was shown that diet for patients with the Hp 1-1 phenotype can lead to greater weight loss and insulin sensitivity compared to the other Hp phenotypes. 29 Thus, the presence of less protective Hp phenotypes could also provide an explanation for the occurrence of 'atypical' HS patients with a normal or decreased BMI.…”

Section: Discussionmentioning

confidence: 99%

“…Two variants of α chain result in three phenotypes Hp 1‐1 (homodimer; α1β‐chain), Hp2‐1 (heterodimer; one α1β‐chain and many α2β‐chains) and Hp2‐2 (homodimer; many α2β‐chains) 25 . Among these variants, Hp 2‐2 was shown to be less protective against oxidative stress and was associated with a variety of cardiovascular diseases 26–28 . Moreover, in one study, it was shown that diet for patients with the Hp 1‐1 phenotype can lead to greater weight loss and insulin sensitivity compared to the other Hp phenotypes 29 .…”

Section: Discussionmentioning

confidence: 99%

“…43.5% of HS patients were female (n = 57) and 56.5% male (n = 74). Median age (interquartile range, IQR) of the HS group was 41 (34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52), and median age (ICR) of onset was 22 (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). In over 80% of patients, the HS began during peripuberty or early adulthood (age 12-34 years).…”

Section: Patients' History and Basic Characteristicsmentioning

confidence: 99%

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Haptoglobin is an independent marker for disease severity and risk for metabolic complications in hidradenitis suppurativa: A prospective study

Abu Rached,

Gambichler,

Ocker

et al. 2023

Acad Dermatol Venereol

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BackgroundHidradenitis suppurativa (HS) is a chronic inflammatory disease that is highly correlated with obesity. Haptoglobin serum levels have recently been recognized as an important biomarker linking obesity with chronic inflammation.ObjectiveTo compare haptoglobin with previously proposed serum biomarkers for the determination of disease severity in HS patients. For this purpose, disease severity of HS patients was determined by a panel of clinical scores as well as several risk factors, such as weight and smoking habits.MethodsA prospective, diagnostic accuracy study was performed at the International Centre for Hidradenitis suppurativa/Acne inversa Bochum (ICH). The study included a total of 263 patients, including 131 who had a confirmed diagnosis of HS in Hurley I (n=16), II (n=56), and III (n=59) HS, and 132 healthy controls. The main outcome was to identify serological inflammatory markers for HS disease severity [severe (III) vs. moderate/mild (II/I)] as assessed by Hurley classification.ResultsThe serum levels of acute phase proteins haptoglobin and CRP, as well as the number of neutrophils in peripheral blood, number of monocytes, the systemic immune‐inflammation index and the pan‐immune‐inflammatory value correlated with disease severity according to established clinical scores (mHSS, SAHS, Hurley, DLQI). HS patients had significantly higher haptologlobin levels compared to healthy controls. Logistic regression analysis revealed haptoglobin as the only independent marker predicting severe HS.ConclusionIn this prospective study, we discovered that the serum levels of the acute phase protein haptoglobin levels serve as an independent marker of disease severity in HS. While this presents the first study in the context of HS. Thus, the present data not only yield a highly promising serum marker to be further validated.

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Haptoglobin phenotype influences the effectiveness of diet-induced weight loss in middle-age abdominally obese women with metabolic abnormalities

Cited by 12 publications

References 39 publications

Exploring a novel therapeutic strategy: the interplay between gut microbiota and high-fat diet in the pathogenesis of metabolic disorders

Exploring a novel therapeutic strategy: the interplay between gut microbiota and high-fat diet in the pathogenesis of metabolic disorders

Intensive lifestyle intervention in type 2 diabetes and risk of incident coronary artery disease for the common haptoglobin phenotypes: the Look AHEAD study

Haptoglobin is an independent marker for disease severity and risk for metabolic complications in hidradenitis suppurativa: A prospective study

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