Haptoglobin phenotype in women with preeclampsia

Sammour, Rami N.; Nakhoul, Farid; Levy, Andrew P.; Miller‐Lotan, Rachel; Nakhoul, Nakhoul; Awad, Hoda; Gonen, Ron; Ohel, Gonen

doi:10.1007/s12020-010-9392-7

Cited by 18 publications

(25 citation statements)

References 23 publications

(24 reference statements)

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“…The largest case-control studies suggested that Hp 1-1 was associated with a lower preeclampsia risk compared to Hp 2-1 [18], or Hp 2-1 and 2-2 [17]. However, we found no relationship between Hp phenotype and preeclampsia risk in 4,500 women from the present trial, suggesting that the results of small case-control studies may have been spurious findings [21].…”

Section: Discussioncontrasting

confidence: 71%

“…Most research examining the relationship between Hp phenotype and adverse pregnancy outcomes focuses on preeclampsia [17, 18, 29, 30]. The largest case-control studies suggested that Hp 1-1 was associated with a lower preeclampsia risk compared to Hp 2-1 [18], or Hp 2-1 and 2-2 [17].…”

Section: Discussionmentioning

confidence: 99%

“…This gestational age was selected for the original study because several large prospective studies reported that abnormal UAD in the second trimester or late first trimester was useful in predicting preeclampsia [1]. Early reports also suggested that Hp phenotype was associated with preeclampsia risk [17, 18]; hence we sought to examine the potential effects of Hp phenotype on UAD both as a vascular test, and as a potential mechanism leading to increased preeclampsia risk. However, subsequent analyses demonstrated that abnormal UAD had poor sensitivity for predicting preeclampsia in this cohort [8], and we were also unable to confirm a relationship between Hp phenotype and preeclampsia risk [21].…”

Section: Discussionmentioning

confidence: 99%

“…Small case-control studies suggest that Hp phenotype may predict adverse pregnancy outcomes, including preeclampsia [17, 18], gestational diabetes [19], and premature rupture of membranes [20]. However, we were unable to confirm a relationship between Hp phenotype and preeclampsia risk in large cohorts of low-risk nulliparous women [21] or women with Type 1 diabetes [22] participating in randomized controlled trials of antioxidants for preeclampsia prevention.…”

Section: Introductionmentioning

confidence: 93%

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Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort

Weissgerber

McGee

Myatt

et al. 2014

The Journal of Maternal-Fetal & Neonatal Medicine

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Objective The anti-oxidant and proangiogenic protein haptoglobin (Hp) is believed to be important for implantation and pregnancy, although its specific role is not known. The three phenotypes (1-1, 2-1 and 2-2) differ in structure and function. Hp 2-2 is associated with increased vascular stiffness in other populations. We examined whether Hp phenotype is associated with abnormal uterine artery Doppler (UAD) in pregnancy. Methods We conducted a secondary analysis of a preeclampsia prediction cohort nested within a larger placebo-controlled randomized clinical trial of antioxidants for prevention of preeclampsia. We determined Hp phenotype in 2,184 women who completed UAD assessments at 17 weeks gestation. Women with notching were re-evaluated for persistent notching at 24 weeks gestation. Logistic regression was used to assess differences in UAD indices between phenotype groups. Results Hp phenotype did not significantly influence the odds of having any notch (p=0.32), bilateral notches (p=0.72), or a resistance index (p = 0.28) or pulsatility index (p = 0.67) above the 90th percentile at 17 weeks gestation. Hp phenotype also did not influence the odds of persistent notching at 24 weeks (p=0.25). Conclusions Hp phenotype is not associated with abnormal UAD at 17 weeks gestation or with persistent notching at 24 weeks.

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Section: Discussioncontrasting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

See 2 more Smart Citations

Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort

Weissgerber

McGee

Myatt

et al. 2014

The Journal of Maternal-Fetal & Neonatal Medicine

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“…Small case-control studies of non-diabetic women have reported that preeclampsia risk was increased, [52], decreased [53, 54], or not different [55] in women with the stronger antioxidant Hp 1-1 phenotype. The heterogeneity of results may have been due to differences in the populations studied.…”

Section: Preeclampsia In Women With Type 1 or Type 2 Diabetesmentioning

confidence: 99%

Preeclampsia and Diabetes

2015

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Preeclampsia is diagnosed in women presenting with new onset hypertension accompanied by proteinuria or other signs of severe organ dysfunction in the second half of pregnancy. Preeclampsia risk is increased two to four-fold among women with type 1 or type 2 diabetes. The limited number of pregnant women with preexisting diabetes and difficulties associated with diagnosing preeclampsia in women with proteinuria prior to pregnancy are significant barriers to research in this high-risk population. GDM also increases preeclampsia risk, although it is unclear whether these two conditions share a common pathophysiological pathway. Non-diabetic women who have had preeclampsia are more likely to develop type 2 diabetes later in life. Among women with type 1 diabetes, a history of preeclampsia is associated with an increased risk of retinopathy and nephropathy. More research examining pathophysiology, treatment and the long-term health implications of preeclampsia among women with preexisting and gestational diabetes is needed.

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siRNA‐mediated NCAM1 gene silencing suppresses oxidative stress in pre‐eclampsia by inhibiting the p38MAPK signaling pathway

Zhang

Han

2019

J of Cellular Biochemistry

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Pre‐eclampsia (PE), whose pathophysiology and etiology remain undefined, represents a leading consequence of fetal and maternal mortality and morbidity. Oxidative stress (OS) is recognized to involve in this disorder. In this study, we hypothesized that neural cell adhesion molecule 1 (NCAM1) gene silencing would suppress the OS in the pregnancy complicated by PE. Initially, clinical samples were collected for determination of NCAM1 expression in placental tissues and levels of OS products in blood. To assess the regulatory mechanism of NCAM1 knockdown on OS, we used small interfering RNA (siRNA) to silence NCAM1 expression in human umbilical vein endothelial cells (HUVECs). Next, cells were treated with or without hypoxia/reoxygenation to observe the level changes of OS products and p38 mitogen‐activated protein kinase (p38MAPK) pathway‐related genes. Finally, an evaluation of HUVEC migration and invasion abilities was conducted by wound‐healing and transwell assays. Placenta of pregnancy with PE presented significantly increased NCAM1 expression in comparison to placenta of normal pregnancy. Meanwhile, enhanced OS in blood of pregnant women with PE was observed relative to women with normal pregnancy. siRNA‐mediated knockdown of NCAM1 gene could inhibit the p38MAPK signaling pathway, repress OS, and promote cell migration and invasion in HUVECs, indicating that NCAM1 inhibition could reduce the influence of PE. Importantly, blocking the p38MAPK signaling pathway reversed the inhibitory role of NCAM1 gene silencing on PE. Collectively, this study defines potential role of NCAM1 gene silencing as a therapeutic target in PE through inhibiting OS and enhancing HUVEC migration and invasion by disrupting the p38MAPK signaling pathway.

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Haptoglobin phenotype in women with preeclampsia

Cited by 18 publications

References 23 publications

Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort

Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort

Preeclampsia and Diabetes

siRNA‐mediated NCAM1 gene silencing suppresses oxidative stress in pre‐eclampsia by inhibiting the p38MAPK signaling pathway

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