Haptoglobin Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological Features

Kaba, Mehmet; Pirinççi, Necip; Benli̇, Erdal; Geçit, İlhan; Güneş, Mustafa; Yüksel, Mehmet Bilgehan; Tok, Adem; Kemik, Ahu Sarbay

doi:10.7314/apjcp.2012.13.12.6063

Cited by 11 publications

(5 citation statements)

References 38 publications

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“…It has been reported that the Hapto serum level changes significantly in cirrhosis and HCC patients [38]. Pirincci N et al found that the serum haptoglobin levels in the patients with bladder cancer were significantly higher compared with healthy controls [18]. Consistent with this previous study, we found that Hapto expression in ECC was obviously higher than in non-tumor tissues.…”

Section: Discussionsupporting

confidence: 91%

“…Similarly, our study showed that the positive rate of Hapto expression was higher in patients with poor differentiation, lymph node metastasis, invasion of surrounding tissues/organs, and a TNM stage of III or IV and no resection. In addition, several tumor types express Hapto, and its expression correlates with poor prognosis in lung cancer, breast cancer, hepatocellular carcinoma, gastric cancer, colorectal cancer, prostate cancer, bladder cancer and ovarian cancer [11][12][13][14][15][16][17][18][19]. In this study, we found similar results that positive Hapto expression negatively correlated with overall survival and positively correlated with mortality.…”

Section: Discussionsupporting

confidence: 78%

“…Consistent with this previous study, we found that Hapto expression in ECC was obviously higher than in non-tumor tissues. Previous studies reported that serum Hapto can predict colorectal cancer hepatic metastasis and Hapto promotes colorectal cancer cell invasion [39], and high serum haptoglobin levels are closely associated with distant metastasis, lymphovascular involvement, lymph node metastasis and increasing tumor burden in bladder cancer [18]. Similarly, our study showed that the positive rate of Hapto expression was higher in patients with poor differentiation, lymph node metastasis, invasion of surrounding tissues/organs, and a TNM stage of III or IV and no resection.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies reported that Hapto may play an important role in anti-infection and anti-cancer by influencing iron metabolism of invading pathogens and tumor cells, and by affecting angiogenesis and other inflammatory processes [9,10]. Recently, several studies have revealed that the elevated cellular expressive level or serum contain of Hapto is associated with various cancers, such as lung cancer, breast cancer, hepatocellular carcinoma, gastric cancer, colorectal cancer, prostate cancer, bladder cancer and ovarian cancer [11][12][13][14][15][16][17][18][19]. Thus, Hapto might be an important marker in reflecting the malignant degrees, biological behaviors, and prognosis of some malignant lesions.…”

Section: Ivyspring International Publishermentioning

confidence: 99%

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Prognostic and clinicopathological significance of Hapto and Gremlin1 expression in extrahepatic cholangiocarcinoma

Liu

Miao

et al. 2020

J. Cancer

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Background: Some studies have demonstrated that Hapto and Gremlin1 play an important biological role in many neoplasms. However, the role of Hapto and Gremlin1 in extrahepatic cholangiocarcinoma (ECC) remains to be revealed. Thus, this study investigated the prognostic and clinicopathological significance of Hapto and Gremlin1 expression in ECC. Methods: We examined Hapto and Gremlin1 expression in 100 ECC, 30 peritumoral tissues, 10 adenoma and 15 normal biliary tract tissues using EnVision immunohistochemistry. The relationship between Hapto and Gremlin 1 expression and clinicopathological parameters was evaluated using the χ 2 test or Fisher's exact test. The overall survival of patients was analyzed using Kaplan-Meier univariate survival analysis and log-rank tests. Results: Hapto and Gremlin1 proteins were overexpressed in ECC compared to peritumoral tissues, adenoma, and normal biliary tract (P<0.05 or P<0.01). The positive rate of Hapto and Gremlin1 expression was significantly higher in cases with poor differentiation, lymph node metastasis, invasion of surrounding tissues and organs, a tumor-node-metastasis (TNM) stage of III or IV and no resection. Kaplan-Meier survival analysis showed that ECC patients with positive Hapto and/or Gremlin1 expression survived significantly shorter than patients with negative Hapto and/or Gremlin1 expression. Cox multivariate analysis revealed that positive Hapto and Gremlin1 expression were independent poor prognostic factors in ECC patients. Conclusion: The present study indicated that positive Hapto and/or Gremlin1 expression are closely associated with the pathogenesis, clinical, pathological and biological behaviors, and poor prognosis in ECC.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Ivyspring International Publishermentioning

confidence: 99%

See 2 more Smart Citations

Prognostic and clinicopathological significance of Hapto and Gremlin1 expression in extrahepatic cholangiocarcinoma

Liu

Miao

et al. 2020

J. Cancer

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“…Three forms of haptoglobin have been identified which may indicate numerous potential splices variants and post-translational modification of haptoglobin. Our finding is consistent with previous ones reporting elevated haptoglobin levels in Turkish and Polish bladder cancer patients 17,31 www.nature.com/scientificreports/ Under normal physiological conditions Haptoglobin stabilize hemoglobin (Hb) through binding and forming a complex with it. Haptoglobin has also significant protective properties against oxidative damage by Hb 32 .…”

Section: Healthy Controls Lg Tumourssupporting

confidence: 93%

Circulating proteomic signature for detection of biomarkers in bladder cancer patients

Nedjadi

Benabdelkamal

Albarakati

et al. 2020

Sci Rep

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The identification of clinically-relevant early diagnostic and prognostic protein biomarkers is essential to maximize therapeutic efficacy and prevent cancer progression. The aim of the current study is to determine whether aberrant plasma protein profile can be applied as a surrogate tool for early diagnosis of bladder carcinoma. Plasma samples from patients with low grade non-muscle invasive bladder cancer and healthy controls were analyzed using combined 2D-DIGE and mass-spectrometry to identify differentially expressed proteins. Validation was performed using western blotting analysis in an independent cohort of cancer patients and controls. Fifteen differentially-expressed proteins were identified of which 12 were significantly up-regulated and three were significantly down-regulated in tumors compared to controls. The Ingenuity Pathways Analysis revealed functional connection between the differentially-expressed proteins and immunological disease, inflammatory disease and cancer mediated through chemokine and cytokine signaling pathway and NF-kB transcription factor. Among the three validated proteins, haptoglobin was able to distinguish between patients with low grade bladder cancer and the controls with high sensitivity and specificity (AUC > 0.87). In conclusion, several biomarker proteins were identified in bladder cancer. Haptoglobin is a potential candidate that merit further investigation to validate its usefulness and functional significance as potential biomarkers for early detection of bladder cancer. Bladder carcinoma (BC) is the second most common cancer of the genitourinary tract and a leading cause of mortality worldwide. According to a recent data, an estimated 450,000 persons developed BC and more than 199,000 persons died of BC in the year 2018 1. Early diagnosis of bladder cancer has a better prognosis with a 10-year disease-free survival of 86% for non-muscle invasive bladder cancer (NMIBC) (stage T0). However, due to the absence of reliable prognostic markers, recurrence rates fluctuate between 30 and 70% with as high as 10-30% rates of progression to muscle-invasive bladder cancer (MIBC) phenotype for high-risk patients 2,3. This situation necessitates vigilant management protocol through frequent cystoscopy/cytology examinations and different treatment modalities. The extended treatment and long-term follow-up make bladder cancer treatment one of the most expensive per patient among all cancers 4. Therefore, biomarkers for early stage screening of non-muscle invasive bladder cancer is desperately needed as it will help in early diagnosis, preventing disease progression to a life-threatening phenotype (MIBC) and will eventually lower the associated costs of treatment. Furthermore, early diagnosis of bladder cancer would be of great importance in discerning patients with high grade cancer from those with low grade cancer and in selecting the appropriate therapeutic approaches. Despite development and FDA-approval of several urine and blood-based biomarker kits for appraisal of bladder ca...

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Differential regulation of urine proteins in urothelial neoplasm

Halder

Dey

Chowdhury

et al. 2015

Journal of Proteomics

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Haptoglobin Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological Features

Cited by 11 publications

References 38 publications

Prognostic and clinicopathological significance of Hapto and Gremlin1 expression in extrahepatic cholangiocarcinoma

Prognostic and clinicopathological significance of Hapto and Gremlin1 expression in extrahepatic cholangiocarcinoma

Circulating proteomic signature for detection of biomarkers in bladder cancer patients

Differential regulation of urine proteins in urothelial neoplasm

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