Haptoglobin, inflammation and disease

Quaye, Isaac

doi:10.1016/j.trstmh.2008.04.010

Cited by 315 publications

(270 citation statements)

References 71 publications

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“…Gelsolin is a calcium-activated actin filament also linked to a number of pathological conditions such as cancer (Spinardi and Witke 2007). Haptoglobin is a protein associated with inflammation (Quaye 2008).…”

Section: Discussionmentioning

confidence: 99%

Development of a serum profile for healthy aging

Byerley

Leamy

Tam

et al. 2010

AGE

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Increasing numbers of Americans are reaching 85 years of age or older, yet there are no reliable biomarkers to predict who will live this long. The goal of this pilot study therefore was: (1) to identify a potential serum pattern that could identify proteins involved in longevity and (2) to determine if this pattern was a marker of longevity in an independent sample of individuals. Serum samples were analyzed in three cohorts of individuals (n=12 in each) aged 20-34, 60-74, and Q90 years who participated in The Louisiana Healthy Aging Study.The 12 most abundant proteins were removed and the remaining proteins separated by two-dimensional gel electrophoresis. Gels were matched and the intensity of each spot quantified. Multivariate discriminant analysis was used to identify a serum pattern that could separate these three age cohorts. Seven protein spots were found that correctly distinguished the subjects into the three groups. However, these spots were not as successful in discriminating the ages in a second set of 15 individuals as only eight of these subjects were placed into their correct group. These preliminary results show that the proteomics approach can be used to identify potential proteins or markers that may be involved in the aging process and/or be important determinants of longevity.

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Section: Discussionmentioning

confidence: 99%

Development of a serum profile for healthy aging

Byerley

Leamy

Tam

et al. 2010

AGE

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“…haptoglobin, albumin and transferrin [2]. Nevertheless, most research focused on CRP despite the important role of for example haptoglobin in the immune response, bacterial translocation and O&NS pathways and a possible association between haptoglobin polymorphism (Hp1 and Hp2) and depression [2,[37][38][39].…”

Section: Gaps and Required Improvements: Biomarkersmentioning

confidence: 99%

Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research

et al. 2015

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Meta-analyses confirm that depression is accompanied by signs of inflammation including increased levels of acute phase proteins, e.g. C-reactive protein, and pro-inflammatory cytokines, e.g. interleukin-6. Supporting the translational significance of this, a meta-analysis showed that anti-inflammatory drugs may have antidepressant effects. Here we argue that inflammation and depression research needs to get onto a new track. Firstly, the choice of inflammatory biomarkers in depression research was often too selective and did not consider the broader pathways.Secondly, although mild inflammatory responses are present in depression, other immune-related pathways cannot be disregarded as new drug targets, e.g. activation of cell-mediated immunity, oxidative and nitrosative stress (O&NS) pathways, autoimmune responses, bacterial translocation, activation of the Toll-like Receptor and neuroprogressive pathways. Thirdly, antiinflammatory treatments are sometimes used without full understanding of their effects on the broader pathways underpinning depression. Since many of the activated immune-inflammatory pathways in depression actually confer protection against an overzealous inflammatory response, targeting these pathways may result in unpredictable and unwanted results. Furthermore, this paper discusses the required improvements in research strategy, i.e. path and drug discovery processes, omics-based techniques and systems biomedicine methodologies. Firstly, novel methods should be employed to examine the intracellular networks that control and modulate the immune, O&NS and neuroprogressive pathways using omics-based assays, including genomics, transcriptomics, proteomics, metabolomics, epigenomics and microbiomics. Secondly, systems biomedicine analyses are essential to unravel the complex interactions between these cellular 4 networks, pathways and the multifactorial trigger factors and to delineate new drug targets in the cellular networks or pathways. Drug discovery processes should delineate new drugs targeting the intracellular networks and immune-related pathways.

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“…In addition, CD163-mediated uptake of hemoglobin may create an antiinflammatory response because heme metabolites have potent anti-inflammatory effects (Moestrup and Moller 2004). Evidence exists for the association between haptoglobin levels and inflammatory diseases, and it is proposed that this protein has an anti-inflammatory/ immunomodulatory function (Quaye 2008). In recent years, it has been proposed, on the basis of structural and functional analysis, that haptoglobin is, like clusterin, a secreted molecular chaperone (Ettrich et al 2002;Yerbury et al 2005).…”

Section: Gp96mentioning

confidence: 99%

Unfolding the relationship between secreted molecular chaperones and macrophage activation states

Henderson

2009

Cell Stress and Chaperones

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Over the last 20 years, it has emerged that many molecular chaperones and protein-folding catalysts are secreted from cells and function, somewhat in the manner of cytokines, as pleiotropic signals for a variety of cells, with much attention being focused on the macrophage. During the last decade, it has become clear that macrophages respond to bacterial, protozoal, parasitic and host signals to generate phenotypically distinct states of activation. These activation states have been termed 'classical' and 'alternative' and represent not a simple bifurcation in response to external signals but a range of cellular phenotypes. From an examination of the literature, the hypothesis is propounded that mammalian molecular chaperones are able to induce a wide variety of alternative macrophage activation states, and this may be a system for relating cellular or tissue stress to appropriate macrophage responses to restore homeostatic equilibrium.

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Haptoglobin, inflammation and disease

Cited by 315 publications

References 71 publications

Development of a serum profile for healthy aging

Development of a serum profile for healthy aging

Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research

Unfolding the relationship between secreted molecular chaperones and macrophage activation states

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