2021
DOI: 10.1080/03630269.2020.1801459
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Haptoglobin Genotypes Associated with Vaso-Occlusive Crisis in Sickle Cell Anemia Patients of Eastern India

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Cited by 8 publications
(10 citation statements)
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“… 8 , 26 The association of the HP genotypes with circulating HP concentrations in patients with SCD is less clear. One SCD cohort demonstrated that the HP 1-1 genotype was associated with higher HP concentrations than HP 2-1 or 2-2, 16 whereas another study did not find any difference. 27 …”
Section: Resultsmentioning
confidence: 96%
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“… 8 , 26 The association of the HP genotypes with circulating HP concentrations in patients with SCD is less clear. One SCD cohort demonstrated that the HP 1-1 genotype was associated with higher HP concentrations than HP 2-1 or 2-2, 16 whereas another study did not find any difference. 27 …”
Section: Resultsmentioning
confidence: 96%
“…8,26 The association of the HP genotypes with circulating HP concentrations in patients with SCD is less clear. One SCD cohort demonstrated that the HP 1-1 genotype was associated with higher HP concentrations than HP 2-1 or 2-2, 16 whereas another study did not find any difference. 27 We observed that the HP 1 allele is associated with higher HP and lower cell-free hemoglobin concentrations at steady state as well as during VOE.…”
Section: Hp Genotypementioning
confidence: 96%
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“…It is associated with multiple acute and chronic complications such as vaso-occlusive crises, acute anemia, splenic sequestration, erythroblastopenia. 1 It is among the most common monogenic diseases worldwide. 2 It is estimated that there are 312,000 new sickle cell patients worldwide, including 236,000 in Sub-Saharan Africa.…”
Section: Introductionmentioning
confidence: 99%