Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin

Guetta, Julia; Strauss, Merav; Levy, Nina S.; Fahoum, Lana; Levy, Andrew P.

doi:10.1016/j.atherosclerosis.2006.04.032

Cited by 115 publications

(98 citation statements)

References 29 publications

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“…CD163 binding of the haptoglobin-1 and forming the haptoglobin/hemogobin complexes-1 rapidly stimulates production of anti-inflammatory cytokines such as IL-10. On the other hand, CD163 binding to the haptoglobin-2 and formed haptoglobin/hemoglobin complexes-2, does not stimulate anti-inflammatory cytokines (8,30). Binding the complex haptoglobin/hemoglobin to CD163 requires the presence of calcium (13,19).…”

Section: Functions Of Cd163 Scavenger Receptormentioning

confidence: 99%

“…It is a hemoglobin binding protein expressed due to genetic polymorphism as three major phenotypes: 1-1 (homozygous for the 1 st allele), 2-1 (heterozygous) and 2-2 (homozygous for the 2 nd allele) (8,16,18). CD163 reveals higher affinity for the complexes haptoglobin/hemoglobin-2 subtype 2-2 complexes compared to complexes haptoglobin/hemoglobin-1 (27).…”

Section: Functions Of Cd163 Scavenger Receptormentioning

confidence: 99%

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Scavenger Receptor CD163 and Its Biological Functions

Onofre

Koláčková

Jankovicova

et al. 2009

Acta Med. (Hradec Kralove, Czech Repub.)

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Summary: CD163 is a member of scavenger receptor super family class B of the first subgroup. It is mapped to the region p13 on chromosome 12. Five different isoforms of CD163 have been described, which differ in the structure of their cytoplasmic domains and putative phosporylation sites. This scavenger receptor is selectively expressed on cells of monocytes and macrophages lineage exclusively. CD163 immunological function is essentially homeostatic. It also has other functions because participates in adhesion to endothelial cells, in tolerance induction and tissues regeneration. Other very important function of CD163 is the clearance of hemoglobin in its cell-free form and participation in anti-inflammation in its soluble form, exhibiting cytokine-like functions. We review the biological functions of CD163 which have been discovered until now. It seems apparent from this review that CD163 scavenger receptor can be used as biomarker in different diseases and as a valuable diagnostic parameter for prognosis of many diseases especially inflammatory disorders and sepsis.

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Section: Functions Of Cd163 Scavenger Receptormentioning

confidence: 99%

Section: Functions Of Cd163 Scavenger Receptormentioning

confidence: 99%

Scavenger Receptor CD163 and Its Biological Functions

Onofre

Koláčková

Jankovicova

et al. 2009

Acta Med. (Hradec Kralove, Czech Repub.)

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“…13) It is also involved in tumor and infection pathogenesis, in that it modulates the switch orientation of the Th1/Th2 response. 11,14) It is produced in the liver and immunological cells and secreted into serum. Its level changes in the serum in response to infection, inflammation, and various malignant diseases, including lung and bladder cancer, 15,16) leukemia, 17) breast cancer, 18) malignant lymphoma, 19) urogenital tumors, 20) and esophageal squamous cell carcinoma.…”

Section: Haptoglobin Proved a Prognostic Biomarker In Peripheral Bloomentioning

confidence: 99%

Haptoglobin Proved a Prognostic Biomarker in Peripheral Blood of Patients with Personalized Peptide Vaccinations for Advanced Castration-Resistant Prostate Cancer

Pang

Tashiro

Eguchi

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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“…21 Interestingly, recent evidence shows that the Hp 1-1 protein dimer is far superior to the Hp 2-2 cyclical polymer in its immunomodulatory and antioxidant effects. [22][23][24][25] We hypothesized that the Hp 2-2 genotype predisposes an individual to chronic cerebral vasospasm after SAH. We assessed the role of the Hp 2-2 genotype by comparing the extent of vasospasm, activity level, and microscopic leukocyte counts between wild-type Hp 1-1 mice and genetically modified Hp 2-2 mice, 24 hours after experimentally induced SAH, corresponding to the time of peak vasospasm in mice.…”

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confidence: 99%

Haptoglobin 2-2 Genotype Determines Chronic Vasospasm After Experimental Subarachnoid Hemorrhage

Chaichana

Levy

Miller‐Lotan

et al. 2007

Stroke

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Background and Purpose-Chronic cerebral arterial vasospasm is the leading cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH). Not all cases of SAH, however, develop chronic vasospasm. Inflammation, specifically leukocyte-endothelial cell interactions, appears to be critical in vasospasm development. Haptoglobin (Hp) is a serum protein that limits the extent of inflammation after a hemorrhagic event. An individual's Hp genotype may predict the severity of the inflammatory response during a hemorrhagic event, and consequently modulate the risk for vasospasm. Methods-Sixty mice (Hp 1-1, nϭ30; Hp 2-2, nϭ30) underwent injection of either autologous blood or normal saline solution into the cisterna magna. An additional 30 mice (15 per genotype) served as controls. The extent and manifestations of vasospasm were assessed by measuring lumen patency, quantifying activity levels, and counting the number of vessel-infiltrated macrophages/neutrophils at 24 hours after injection, which corresponds to the time of peak vasospasm in mice. Results-Genetically

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Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin

Cited by 115 publications

References 29 publications

Scavenger Receptor CD163 and Its Biological Functions

Scavenger Receptor CD163 and Its Biological Functions

Haptoglobin Proved a Prognostic Biomarker in Peripheral Blood of Patients with Personalized Peptide Vaccinations for Advanced Castration-Resistant Prostate Cancer

Haptoglobin 2-2 Genotype Determines Chronic Vasospasm After Experimental Subarachnoid Hemorrhage

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