Haptoglobin and Increased Haemolysis

Chronic haemolysis occurring in patients following cardiac surgery.

“…While this would account for the lack of haptoglobin and methaemalbuminmmia immediately after operation, it would not account for these findings after many months. Reerink-Brongers, Prins, and Krijnen (1962) found low levels of haptoglobin when the 5tCr halftime was less than 20 days (TI 51Cr). This represents a destruction rate of greater than twice normal (Donohue et al, 1955).…”

Evaluation of haptoglobin phenotype 0-0 in cirrhotic and non-cirrhotic hospital populations

“…Illnesses accompanied by intravascular haemolysis (Brus and Lewis, 1959;Owen, DeGruchy, and Smith, 1960;Reerink-Brongers, Prins, and Krijnen, 1962) and/or liver disease with hepatocellular dysfunction (Jayle and Boussier, 1955;Owen, MacKay, and Got, 1959) can result in hypohaptoglobinaemia which is characterized by a reduction of the serum haptoglobin to a 'This research was supported by clinical pharmacology training grant number HE 5616-05 from the National Heart Institute and in part by contract PH-43-67-1485, National level below the accepted normal range of 40 to 180 mg %, expressed as haemoglobin-binding capacity (Nyman, 1959;Bayani-Sioson, Lauch, Sutton, Neel, Home, and Gershowitz, 1962). If depletion is severe (ie, haemoglobin-binding capacity of less than 20 mg %) then electrophoresis on starch gel may show an apparent absence of haptoglobin-haemoglobin protein complexes (anhaptoglobinaemia).…”